High-Dose Interferon Alfa in Treating Patients With Stage II or Stage III Melanoma
Phase III Randomized Study of Four Weeks of High Dose Interferon Alfa-2b in Stage T2bN0, T3a-bN0, T4a-bN0, and T1-4, N1a,2a (Microscopic) Melanoma
3 other identifiers
interventional
1,150
4 countries
533
Brief Summary
RATIONALE: Interferon alfa may interfere with the growth of cancer cells. It is not yet known whether treatment with interferon alfa is more effective than observation alone for stage II or stage III melanoma that has been completely removed surgically. PURPOSE: This randomized phase III trial is studying high dose interferon alfa to see how well it works compared to observation only in treating patients with stage II or stage III melanoma that has been completely removed by surgery.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3
Started Mar 1999
Longer than P75 for phase_3
533 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 25, 1999
CompletedFirst Submitted
Initial submission to the registry
November 1, 1999
CompletedFirst Posted
Study publicly available on registry
January 27, 2003
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2015
CompletedResults Posted
Study results publicly available
May 4, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2026
ExpectedFebruary 25, 2026
February 1, 2026
15.8 years
November 1, 1999
February 2, 2016
February 6, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
5-year Relapse-free Survival Rate
Relapse-free survival (RFS) was defined as time from randomization to disease relapse or death from any cause, whichever occurred first. Patients without disease relapse were censored at last disease assessment date known of free of relapse. Kaplan-Meier method was used to estimate 5-year RFS rate in the intent-to-treat (ITT) patients.
assessed every 3 months for 2 years, every 6 months for 3 years
Secondary Outcomes (1)
5-year Overall Survival Rate
assessed every 3 months for 2 years, every 6 months for 3 years
Study Arms (2)
Observation
OTHERPatients undergo observation for 4 weeks.
Interferon Alfa-2b
EXPERIMENTALPatients receive high-dose interferon alfa-2b IV over 20 minutes daily for 5 consecutive days. Treatment repeats weekly for 4 weeks in the absence of unacceptable toxicity.
Interventions
Given IV
Patients undergo observation for 4 weeks.
Eligibility Criteria
You may qualify if:
- Histologically confirmed primary melanoma of cutaneous origin
- Stage II (T3 N0 M0 1.5-4.0 mm Breslow depth)
- Clinically negative regional lymph node pathologic status unknown OR
- Histologically negative regional lymph nodes
- Stage III (T4 N0 M0)
- Greater than 4.0 mm Breslow depth OR
- Stage III (T1-4 N1)
- One lymph node positive microscopically
- Patients must meet at least 1 of the following criteria:
- T2b N0 - primary melanoma 1.01-2.0 mm with ulceration, node negative
- T3a-b N0 - primary melanoma 2.01-4.0 mm with and without ulceration, node negative
- T4a-b N0 - primary melanoma \> 4.0 mm with or without ulceration, node negative
- T1a N1a-2a (microscopic) - primary melanoma of any thickness with microscopically positive lymph node (any number)
- Patients with a positive sentinel node should undergo complete lymphadenectomy of the nodal basin prior to study
- Must complete all primary therapy (wide excision with or without lymphadenectomy) and be randomized in this study within 84 days of wide excision
- +19 more criteria
You may not qualify if:
- Clinical, radiological/laboratory, or pathological evidence of incompletely resected melanoma or any distant metastatic disease
- Clinically palpable lymphadenopathy
- Evidence of organic brain syndrome or significant impairment of basal cognitive function or any psychiatric disorder that would preclude study participation
- Other significant medical or surgical condition, or any medication or treatment regimens, that would interfere with study participation
- Pregnant or nursing
- Other history of invasive melanoma
- Autoimmune disorders or conditions of immunosuppression
- History of active ischemic heart disease
- Cerebrovascular disease
- Congestive heart failure (New York Heart Association class III or IV heart disease)
- Prior or concurrent chemotherapy
- Prior immunotherapy including tumor vaccines, interferon, interleukins, levamisole, or other biologic response modifiers for melanoma
- Concurrent systemic corticosteroids including oral steroids (i.e., prednisone, dexamethasone), topical steroid creams or ointments, or any steroid-containing inhalers
- Prior or concurrent radiotherapy
- Other concurrent immunosuppressive medications
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- ECOG-ACRIN Cancer Research Grouplead
- National Cancer Institute (NCI)collaborator
- SWOG Cancer Research Networkcollaborator
- Cancer and Leukemia Group Bcollaborator
- NCIC Clinical Trials Groupcollaborator
- Children's Oncology Groupcollaborator
Study Sites (533)
UAB Comprehensive Cancer Center
Birmingham, Alabama, 35294, United States
University of South Alabama Mitchell Cancer Institute
Mobile, Alabama, 36688, United States
Arizona Cancer Center at University of Arizona Health Sciences Center
Tucson, Arizona, 85724-5024, United States
Hembree Mercy Cancer Center at St. Edward Mercy Medical Center
Fort Smith, Arkansas, 72903, United States
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
Little Rock, Arkansas, 72205, United States
Kaiser Permanente - Deer Valley
Antioch, California, 94531, United States
Alta Bates Summit Comprehensive Cancer Center
Berkeley, California, 94704, United States
Peninsula Medical Center
Burlingame, California, 94010, United States
Southern California Permanente Medical Group
Downey, California, 90027, United States
Kaiser Permanente - Fremont
Fremont, California, 94538, United States
Marin Cancer Institute at Marin General Hospital
Greenbrae, California, 94904, United States
Kaiser Permanente Medical Center - Hayward
Hayward, California, 94545, United States
Loma Linda University Cancer Institute at Loma Linda University Medical Center
Loma Linda, California, 92354, United States
Kaiser Permanente Medical Center - Oakland
Oakland, California, 94611, United States
Veterans Affairs Medical Center - Palo Alto
Palo Alto, California, 94304, United States
Kaiser Permanente Medical Center - Redwood City
Redwood City, California, 94063, United States
Kaiser Permanente Medical Center - Richmond
Richmond, California, 94801, United States
Kaiser Permanente Medical Center - Roseville
Roseville, California, 95661, United States
Sutter Cancer Center at Roseville Medical Center
Roseville, California, 95661, United States
Sutter Cancer Center
Sacramento, California, 95816, United States
South Sacramento Kaiser-Permanente Medical Center
Sacramento, California, 95823, United States
Kaiser Permanente Medical Center - Sacramento
Sacramento, California, 95825, United States
Kaiser Permanente Medical Office -Vandever Medical Office
San Diego, California, 92120, United States
Naval Medical Center - San Diego
San Diego, California, 92134, United States
Kaiser Permanente Medical Center - San Francisco Geary Campus
San Francisco, California, 94115, United States
California Pacific Medical Center - California Campus
San Francisco, California, 94118, United States
Kaiser Permanente Medical Center - Santa Teresa
San Jose, California, 95119, United States
Kaiser Foundation Hospital - San Rafael
San Rafael, California, 94903, United States
Sutter Health - Western Division Cancer Research Group
San Rafael, California, 94903, United States
Kaiser Permanente Medical Center - Santa Clara Kiely Campus
Santa Clara, California, 95051, United States
Kaiser Permanente Medical Center - Santa Rosa
Santa Rosa, California, 95403, United States
Kaiser Permanente Medical Center - South San Francisco
South San Francisco, California, 94080, United States
Stanford Cancer Center
Stanford, California, 94305-5824, United States
Kaiser Permanente Medical Facility - Stockton
Stockton, California, 95210, United States
Kaiser Permanente Medical Center - Vallejo
Vallejo, California, 94589, United States
Sutter Solano Medical Center
Vallejo, California, 94589, United States
Kaiser Permanente Medical Center - Walnut Creek
Walnut Creek, California, 94596, United States
Aurora Presbyterian Hospital
Aurora, Colorado, 80012, United States
Boulder Community Hospital
Boulder, Colorado, 80301-9019, United States
Penrose Cancer Center at Penrose Hospital
Colorado Springs, Colorado, 80933, United States
St. Anthony Central Hospital
Denver, Colorado, 80204, United States
Kaiser Permanente - Denver
Denver, Colorado, 80205, United States
Porter Adventist Hospital
Denver, Colorado, 80210, United States
Presbyterian - St. Luke's Medical Center
Denver, Colorado, 80218, United States
St. Joseph Hospital
Denver, Colorado, 80218, United States
Rose Medical Center
Denver, Colorado, 80220, United States
CCOP - Colorado Cancer Research Program
Denver, Colorado, 80224-2522, United States
Swedish Medical Center
Englewood, Colorado, 80110, United States
St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center
Grand Junction, Colorado, 81502, United States
North Colorado Medical Center
Greeley, Colorado, 80631, United States
Kaiser Permanente - Lafayette
Lafayette, Colorado, 80026, United States
Sky Ridge Medical Center
Lone Tree, Colorado, 80124, United States
Hope Cancer Care Center at Longmont United Hospital
Longmont, Colorado, 80501, United States
McKee Medical Center
Loveland, Colorado, 80539, United States
St. Mary - Corwin Regional Medical Center
Pueblo, Colorado, 81004, United States
North Suburban Medical Center
Thornton, Colorado, 80229, United States
Exempla Lutheran Medical Center
Wheat Ridge, Colorado, 80033, United States
Praxair Cancer Center at Danbury Hospital
Danbury, Connecticut, 06810, United States
Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center
Hartford, Connecticut, 06105, United States
Eastern Connecticut Hematology and Oncology Associates
Norwich, Connecticut, 06360, United States
Carl and Dorothy Bennett Cancer Center at Stamford Hospital
Stamford, Connecticut, 06904, United States
Tunnell Cancer Center at Beebe Medical Center
Lewes, Delaware, 19958, United States
CCOP - Christiana Care Health Services
Newark, Delaware, 19713, United States
Herbert D. Kerman Regional Oncology Center - Daytona Beach
Daytona Beach, Florida, 32114, United States
Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital
Fort Lauderdale, Florida, 33308, United States
Baptist Cancer Institute - Jacksonville
Jacksonville, Florida, 32207, United States
Ella Milbank Foshay Cancer Center at Jupiter Medical Center
Jupiter, Florida, 33458, United States
Lakeland Regional Cancer Center at Lakeland Regional Medical Center
Lakeland, Florida, 33805, United States
University of Miami Sylvester Comprehensive Cancer Center - Miami
Miami, Florida, 33136, United States
CCOP - Mount Sinai Medical Center
Miami Beach, Florida, 33140, United States
Sacred Heart Cancer Center at Sacred Heart Hospital
Pensacola, Florida, 32504, United States
West Florida Cancer Institute at West Florida Hospital - Pensacola
Pensacola, Florida, 32514, United States
Florida Cancer Specialists - Sarasota Downtown
Sarasota, Florida, 34236, United States
All Children's Hospital
St. Petersburg, Florida, 33701, United States
Kaplan Cancer Center at St. Mary's Medical Center
West Palm Beach, Florida, 33407, United States
Piedmont Hospital
Atlanta, Georgia, 30309, United States
AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Egleston Campus
Atlanta, Georgia, 30322, United States
Winship Cancer Institute of Emory University
Atlanta, Georgia, 30322, United States
Northside Hospital Cancer Center
Atlanta, Georgia, 30342-1611, United States
Saint Joseph's Hospital of Atlanta
Atlanta, Georgia, 30342-1701, United States
CCOP - Atlanta Regional
Atlanta, Georgia, 30342, United States
MBCCOP - Medical College of Georgia Cancer Center
Augusta, Georgia, 30912, United States
WellStar Cobb Hospital
Austell, Georgia, 30106, United States
John B. Amos Cancer Center
Columbus, Georgia, 31904, United States
Charles B. Eberhart Cancer Center at DeKalb Medical Center
Decatur, Georgia, 30033, United States
Veterans Affairs Medical Center - Atlanta (Decatur)
Decatur, Georgia, 30033, United States
Northeast Georgia Medical Center
Gainesville, Georgia, 30501, United States
Gwinnett Medical Center
Lawrenceville, Georgia, 30045, United States
Kennestone Cancer Center at Wellstar Kennestone Hospital
Marietta, Georgia, 30060, United States
Southern Regional Medical Center
Riverdale, Georgia, 30274-2600, United States
Harbin Clinic Cancer Center - Medical Oncology
Rome, Georgia, 30165, United States
Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler
Savannah, Georgia, 31405, United States
Kaiser Permanente - Moanalua Medical Center and Clinic
Honolulu, Hawaii, 96819, United States
Rush-Copley Cancer Care Center
Aurora, Illinois, 60504, United States
Hematology Oncology Associates of Illinois - Berwyn
Berwyn, Illinois, 60402, United States
Robert H. Lurie Comprehensive Cancer Center at Northwestern University
Chicago, Illinois, 60611-3013, United States
Hematology and Oncology Associates
Chicago, Illinois, 60611, United States
Saint Joseph Hospital
Chicago, Illinois, 60657, United States
Decatur Memorial Hospital Cancer Care Institute
Decatur, Illinois, 62526, United States
Crossroads Cancer Center
Effingham, Illinois, 62401, United States
Evanston Hospital
Evanston, Illinois, 60201-1781, United States
Ingalls Cancer Care Center at Ingalls Memorial Hospital
Harvey, Illinois, 60426, United States
Kellogg Cancer Care Center
Highland Park, Illinois, 60035, United States
Hinsdale Hematology Oncology Associates
Hinsdale, Illinois, 60521, United States
Midwest Center for Hematology/Oncology
Joliet, Illinois, 60432, United States
North Shore Oncology and Hematology Associates, Limited - Libertyville
Libertyville, Illinois, 60048, United States
La Grange Oncology Associates - Geneva
Naperville, Illinois, 60563, United States
Cancer Care and Hematology Specialists of Chicagoland - Niles
Niles, Illinois, 60714, United States
Swedish-American Regional Cancer Center
Rockford, Illinois, 61104-2315, United States
Hematology Oncology Associates - Skokie
Skokie, Illinois, 60076, United States
Carle Cancer Center at Carle Foundation Hospital
Urbana, Illinois, 61801, United States
CCOP - Carle Cancer Center
Urbana, Illinois, 61801, United States
St. Francis Hospital and Health Centers - Beech Grove Campus
Beech Grove, Indiana, 46107, United States
Elkhart Clinic, LLC
Elkhart, Indiana, 46514-2098, United States
Michiana Hematology-Oncology, PC - Elkhart
Elkhart, Indiana, 46514, United States
Elkhart General Hospital
Elkhart, Indiana, 46515, United States
Indiana University Melvin and Bren Simon Cancer Center
Indianapolis, Indiana, 46202-5289, United States
William N. Wishard Memorial Hospital
Indianapolis, Indiana, 46202, United States
Howard Community Hospital
Kokomo, Indiana, 46904, United States
Center for Cancer Therapy at LaPorte Hospital and Health Services
La Porte, Indiana, 46350, United States
Michiana Hematology Oncology PC - La Porte
La Porte, Indiana, 46350, United States
Saint Anthony Memorial Health Centers
Michigan City, Indiana, 46360, United States
Michiana Hematology-Oncology, PC - South Bend
Mishawaka, Indiana, 46545-1470, United States
Saint Joseph Regional Medical Center
Mishawaka, Indiana, 46545-1470, United States
Cancer Center at Ball Memorial Hospital
Muncie, Indiana, 47303-3499, United States
Medical Consultants, PC at Ball Memorial Cancer Center
Muncie, Indiana, 47303, United States
Michiana Hematology Oncology PC - Plymouth
Plymouth, Indiana, 46563, United States
Reid Hospital & Health Care Services
Richmond, Indiana, 47374, United States
CCOP - Northern Indiana CR Consortium
South Bend, Indiana, 46601, United States
Memorial Hospital of South Bend
South Bend, Indiana, 46601, United States
South Bend Clinic
South Bend, Indiana, 46617, United States
McFarland Clinic, PC
Ames, Iowa, 50010, United States
Cedar Rapids Oncology Associates
Cedar Rapids, Iowa, 52403, United States
Mercy Regional Cancer Center at Mercy Medical Center
Cedar Rapids, Iowa, 52403, United States
Medical Oncology and Hematology Associates - West Des Moines
Clive, Iowa, 50325, United States
Genesis Regional Cancer Center at Genesis Medical Center
Davenport, Iowa, 52803, United States
Genesis Medical Center - West Campus
Davenport, Iowa, 52804, United States
Mercy Capitol Hospital
Des Moines, Iowa, 50307, United States
CCOP - Iowa Oncology Research Association
Des Moines, Iowa, 50309, United States
John Stoddard Cancer Center at Iowa Methodist Medical Center
Des Moines, Iowa, 50309, United States
Medical Oncology and Hematology Associates at John Stoddard Cancer Center
Des Moines, Iowa, 50309, United States
Medical Oncology and Hematology Associates at Mercy Cancer Center
Des Moines, Iowa, 50314, United States
Mercy Cancer Center at Mercy Medical Center - Des Moines
Des Moines, Iowa, 50314, United States
John Stoddard Cancer Center at Iowa Lutheran Hospital
Des Moines, Iowa, 50316, United States
McCreery Cancer Center at Ottumwa Regional
Ottumwa, Iowa, 52501, United States
Siouxland Hematology-Oncology Associates, LLP
Sioux City, Iowa, 51101, United States
Mercy Medical Center - Sioux City
Sioux City, Iowa, 51104, United States
St. Luke's Regional Medical Center
Sioux City, Iowa, 51104, United States
Covenant Cancer Treatment Center
Waterloo, Iowa, 50702, United States
Hospital District Sixth of Harper County
Anthony, Kansas, 67003, United States
Cancer Center of Kansas, PA - Chanute
Chanute, Kansas, 66720, United States
Cancer Center of Kansas, PA - Dodge City
Dodge City, Kansas, 67801, United States
Cancer Center of Kansas, PA - El Dorado
El Dorado, Kansas, 67042, United States
Cancer Center of Kansas - Fort Scott
Fort Scott, Kansas, 66701, United States
Cancer Center of Kansas-Independence
Independence, Kansas, 67301, United States
Cancer Center of Kansas, PA - Kingman
Kingman, Kansas, 67068, United States
Lawrence Memorial Hospital
Lawrence, Kansas, 66044, United States
Cancer Center of Kansas, PA - Liberal
Liberal, Kansas, 67905, United States
Cancer Center of Kansas, PA - Newton
Newton, Kansas, 67114, United States
Menorah Medical Center
Overland Park, Kansas, 66209, United States
Saint Luke's Hospital - South
Overland Park, Kansas, 66213, United States
Cancer Center of Kansas, PA - Parsons
Parsons, Kansas, 67357, United States
Cancer Center of Kansas, PA - Pratt
Pratt, Kansas, 67124, United States
Cancer Center of Kansas, PA - Salina
Salina, Kansas, 67401, United States
Tammy Walker Cancer Center at Salina Regional Health Center
Salina, Kansas, 67401, United States
Shawnee Mission Medical Center
Shawnee Mission, Kansas, 66204, United States
Cotton-O'Neil Cancer Center
Topeka, Kansas, 66606, United States
Cancer Center of Kansas, PA - Wellington
Wellington, Kansas, 67152, United States
Associates in Womens Health, PA - North Review
Wichita, Kansas, 67208, United States
Cancer Center of Kansas, PA - Medical Arts Tower
Wichita, Kansas, 67208, United States
Cancer Center of Kansas, PA - Wichita
Wichita, Kansas, 67214, United States
CCOP - Wichita
Wichita, Kansas, 67214, United States
Via Christi Cancer Center at Via Christi Regional Medical Center
Wichita, Kansas, 67214, United States
Cancer Center of Kansas, PA - Winfield
Winfield, Kansas, 67156, United States
Cancer Care at Our Lady of Bellefonte Hospital
Ashland, Kentucky, 41101, United States
Drs. Carrol, Sheth, Raghavan
Louisville, Kentucky, 40215, United States
Tulane Cancer Center Office of Clinical Research
Alexandria, Louisiana, 71315-3198, United States
Ochsner Health Center - Bluebonnet
Baton Rouge, Louisiana, 70809, United States
Louisiana State University Health Sciences Center - Monroe
Monroe, Louisiana, 71210, United States
CCOP - Ochsner
New Orleans, Louisiana, 70121, United States
Ochsner Cancer Institute at Ochsner Clinic Foundation
New Orleans, Louisiana, 70121, United States
Feist-Weiller Cancer Center at Louisiana State University Health Sciences
Shreveport, Louisiana, 71130-3932, United States
Maine Center for Cancer Medicine and Blood Disorders - Scarborough
Scarborough, Maine, 04074, United States
DeCesaris Cancer Institute at Anne Arundel Medical Center
Annapolis, Maryland, 21401, United States
Greater Baltimore Medical Center Cancer Center
Baltimore, Maryland, 21204, United States
Union Hospital Cancer Program at Union Hospital
Elkton, Maryland, 21921, United States
Tufts-NEMC Cancer Center
Boston, Massachusetts, 02111, United States
Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215, United States
Hickman Cancer Center at Bixby Medical Center
Adrian, Michigan, 49221, United States
Saint Joseph Mercy Cancer Center
Ann Arbor, Michigan, 48106-0995, United States
CCOP - Michigan Cancer Research Consortium
Ann Arbor, Michigan, 48106, United States
Oakwood Cancer Center at Oakwood Hospital and Medical Center
Dearborn, Michigan, 48123-2500, United States
Barbara Ann Karmanos Cancer Institute
Detroit, Michigan, 48201-1379, United States
Green Bay Oncology, Limited - Escanaba
Escanaba, Michigan, 49431, United States
Genesys Hurley Cancer Institute
Flint, Michigan, 48503, United States
Hurley Medical Center
Flint, Michigan, 48503, United States
Van Elslander Cancer Center at St. John Hospital and Medical Center
Grosse Pointe Woods, Michigan, 48236, United States
Dickinson County Healthcare System
Iron Mountain, Michigan, 49801, United States
Foote Memorial Hospital
Jackson, Michigan, 49201, United States
Borgess Medical Center
Kalamazoo, Michigan, 49001, United States
West Michigan Cancer Center
Kalamazoo, Michigan, 49007-3731, United States
Bronson Methodist Hospital
Kalamazoo, Michigan, 49007, United States
Haematology-Oncology Associates of Ohio and Michigan, PC
Lambertville, Michigan, 48144, United States
Sparrow Regional Cancer Center
Lansing, Michigan, 48912-1811, United States
St. Mary Mercy Hospital
Livonia, Michigan, 48154, United States
Community Cancer Center of Monroe
Monroe, Michigan, 48162, United States
Mercy Memorial Hospital - Monroe
Monroe, Michigan, 48162, United States
Michiana Hematology Oncology PC - Niles
Niles, Michigan, 49120, United States
St. Joseph Mercy Oakland
Pontiac, Michigan, 48341-2985, United States
Mercy Regional Cancer Center at Mercy Hospital
Port Huron, Michigan, 48060, United States
William Beaumont Hospital - Royal Oak Campus
Royal Oak, Michigan, 48073, United States
Seton Cancer Institute at Saint Mary's - Saginaw
Saginaw, Michigan, 48601, United States
Lakeland Regional Cancer Care Center - St. Joseph
Saint Joseph, Michigan, 49085, United States
Lakeside Cancer Specialists, PLLC
Saint Joseph, Michigan, 49085, United States
St. John Macomb Hospital
Warren, Michigan, 48093, United States
Unknown Facility
Alexandria, Minnesota, 56308, United States
MeritCare Bemidji
Bemidji, Minnesota, 56601, United States
Fairview Ridges Hospital
Burnsville, Minnesota, 55337, United States
Mercy and Unity Cancer Center at Mercy Hospital
Coon Rapids, Minnesota, 55433, United States
Duluth Clinic Cancer Center - Duluth
Duluth, Minnesota, 55805-1983, United States
CCOP - Duluth
Duluth, Minnesota, 55805, United States
Miller - Dwan Medical Center
Duluth, Minnesota, 55805, United States
St. Luke's Hospital Cancer Care Center
Duluth, Minnesota, 55805, United States
Fairview Southdale Hospital
Edina, Minnesota, 55435, United States
Fergus Falls Medical Group, PA
Fergus Falls, Minnesota, 56537, United States
Mercy and Unity Cancer Center at Unity Hospital
Fridley, Minnesota, 55432, United States
Hutchinson Area Health Care
Hutchinson, Minnesota, 55350, United States
HealthEast Cancer Care at St. John's Hospital
Maplewood, Minnesota, 55109, United States
Minnesota Oncology Hematology, PA - Maplewood
Maplewood, Minnesota, 55109, United States
Virginia Piper Cancer Institute at Abbott - Northwestern Hospital
Minneapolis, Minnesota, 55407, United States
Hennepin County Medical Center - Minneapolis
Minneapolis, Minnesota, 55415, United States
Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center
Robbinsdale, Minnesota, 55422-2900, United States
CentraCare Clinic - River Campus
Saint Cloud, Minnesota, 56303, United States
Coborn Cancer Center
Saint Cloud, Minnesota, 56303, United States
CCOP - Metro-Minnesota
Saint Louis Park, Minnesota, 55416, United States
Park Nicollet Cancer Center
Saint Louis Park, Minnesota, 55416, United States
Regions Hospital Cancer Care Center
Saint Paul, Minnesota, 55101, United States
United Hospital
Saint Paul, Minnesota, 55102, United States
St. Francis Cancer Center at St. Francis Medical Center
Shakopee, Minnesota, 55379, United States
Ridgeview Medical Center
Waconia, Minnesota, 55387, United States
Willmar Cancer Center at Rice Memorial Hospital
Willmar, Minnesota, 56201, United States
Minnesota Oncology Hematology, PA - Woodbury
Woodbury, Minnesota, 55125, United States
University of Mississippi Cancer Clinic
Jackson, Mississippi, 39216-4505, United States
Saint Luke's Hospital
Chesterfield, Missouri, 63017, United States
Ellis Fischel Cancer Center at University of Missouri - Columbia
Columbia, Missouri, 65203, United States
Children's Mercy Hospital
Kansas City, Missouri, 64108, United States
Truman Medical Center - Hospital Hill
Kansas City, Missouri, 64108, United States
Saint Luke's Cancer Institute at Saint Luke's Hospital
Kansas City, Missouri, 64111, United States
St. Joseph Medical Center
Kansas City, Missouri, 64114, United States
North Kansas City Hospital
Kansas City, Missouri, 64116, United States
Heartland Hematology Oncology Associates, Incorporated
Kansas City, Missouri, 64118, United States
CCOP - Kansas City
Kansas City, Missouri, 64131, United States
Research Medical Center
Kansas City, Missouri, 64132, United States
Saint Luke's East - Lee's Summit
Lee's Summit, Missouri, 64086, United States
Liberty Hospital
Liberty, Missouri, 64068, United States
Heartland Regional Medical Center
Saint Joseph, Missouri, 64506, United States
Saint Joseph Oncology, Incorporated
Saint Joseph, Missouri, 64507, United States
CCOP - Cancer Research for the Ozarks
Springfield, Missouri, 65802, United States
St. John's Regional Health Center
Springfield, Missouri, 65804, United States
Hulston Cancer Center at Cox Medical Center South
Springfield, Missouri, 65807, United States
Missouri Baptist Cancer Center
St Louis, Missouri, 63131, United States
Arch Medical Services, Incorporated at Center for Cancer Care and Research
St Louis, Missouri, 63141, United States
CCOP - Montana Cancer Consortium
Billings, Montana, 59101, United States
Hematology-Oncology Centers of the Northern Rockies - Billings
Billings, Montana, 59101, United States
Northern Rockies Radiation Oncology Center
Billings, Montana, 59101, United States
Billings Clinic - Downtown
Billings, Montana, 59107-7000, United States
Bozeman Deaconess Cancer Center
Bozeman, Montana, 59715, United States
St. James Healthcare Cancer Care
Butte, Montana, 59701, United States
Big Sky Oncology
Great Falls, Montana, 59405-5309, United States
Great Falls Clinic - Main Facility
Great Falls, Montana, 59405, United States
Sletten Cancer Institute at Benefis Healthcare
Great Falls, Montana, 59405, United States
Northern Montana Hospital
Havre, Montana, 59501, United States
St. Peter's Hospital
Helena, Montana, 59601, United States
Glacier Oncology, PLLC
Kalispell, Montana, 59901, United States
Kalispell Medical Oncology at KRMC
Kalispell, Montana, 59901, United States
Montana Cancer Specialists at Montana Cancer Center
Missoula, Montana, 59807-7877, United States
Montana Cancer Center at St. Patrick Hospital and Health Sciences Center
Missoula, Montana, 59807, United States
Saint Francis Cancer Treatment Center at Saint Francis Memorial Health Center
Grand Island, Nebraska, 68803, United States
Cancer Resource Center - Lincoln
Lincoln, Nebraska, 68510, United States
CCOP - Missouri Valley Cancer Consortium
Omaha, Nebraska, 68106, United States
Immanuel Medical Center
Omaha, Nebraska, 68122, United States
Alegant Health Cancer Center at Bergan Mercy Medical Center
Omaha, Nebraska, 68124, United States
Creighton University Medical Center
Omaha, Nebraska, 68131-2197, United States
UNMC Eppley Cancer Center at the University of Nebraska Medical Center
Omaha, Nebraska, 68198-6805, United States
Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center
Lebanon, New Hampshire, 03756-0002, United States
Norris Cotton Cancer Center at Catholic Medical Center
Manchester, New Hampshire, 03102, United States
Hunterdon Regional Cancer Center at Hunterdon Medical Center
Flemington, New Jersey, 08822, United States
CCOP - Northern New Jersey
Hackensack, New Jersey, 07601, United States
Hackensack University Medical Center Cancer Center
Hackensack, New Jersey, 07601, United States
Cancer Institute of New Jersey at Hamilton
Hamilton, New Jersey, 08690, United States
Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School
New Brunswick, New Jersey, 08903, United States
Frederick R. and Betty M. Smith Cancer Treatment Center
Sparta, New Jersey, 07871, United States
Cancer Institute of New Jersey at Cooper - Voorhees
Voorhees Township, New Jersey, 08043, United States
University of New Mexico Cancer Center
Albuquerque, New Mexico, 87131-5636, United States
CCOP - Hematology-Oncology Associates of Central New York
East Syracuse, New York, 13057, United States
Charles R. Wood Cancer Center at Glens Falls Hospital
Glens Falls, New York, 12801, United States
Monter Cancer Center of the North Shore-LIJ Health System
Lake Success, New York, 11042, United States
CCOP - North Shore University Hospital
Manhasset, New York, 11030, United States
Don Monti Comprehensive Cancer Center at North Shore University Hospital
Manhasset, New York, 11030, United States
Long Island Jewish Medical Center
New Hyde Park, New York, 11040, United States
Stony Brook University Cancer Center
Stony Brook, New York, 11794-9446, United States
SUNY Upstate Medical University Hospital
Syracuse, New York, 13210, United States
Randolph Hospital
Asheboro, North Carolina, 27203-5400, United States
Blumenthal Cancer Center at Carolinas Medical Center
Charlotte, North Carolina, 28232-2861, United States
Presbyterian Cancer Center at Presbyterian Hospital
Charlotte, North Carolina, 28233-3549, United States
Duke Comprehensive Cancer Center
Durham, North Carolina, 27710, United States
Wayne Memorial Hospital, Incorporated
Goldsboro, North Carolina, 27534, United States
Moses Cone Regional Cancer Center at Wesley Long Community Hospital
Greensboro, North Carolina, 27403-1198, United States
Leo W. Jenkins Cancer Center at ECU Medical School
Greenville, North Carolina, 27834, United States
Annie Penn Cancer Center
Reidsville, North Carolina, 27320, United States
CCOP - MeritCare Hospital
Fargo, North Dakota, 58122, United States
MeritCare Broadway
Fargo, North Dakota, 58122, United States
Akron Children's Hospital
Akron, Ohio, 44308-1062, United States
Summa Center for Cancer Care at Akron City Hospital
Akron, Ohio, 44309-2090, United States
Barberton Citizens Hospital
Barberton, Ohio, 44203, United States
Mary Rutan Hospital
Bellefontaine, Ohio, 43311, United States
Wood County Oncology Center
Bowling Green, Ohio, 43402, United States
Mercy Cancer Center at Mercy Medical Center
Canton, Ohio, 44708, United States
Aultman Cancer Center at Aultman Hospital
Canton, Ohio, 44710-1799, United States
Adena Regional Medical Center
Chillicothe, Ohio, 45601, United States
Christ Hospital Cancer Center
Cincinnati, Ohio, 45219, United States
Charles M. Barrett Cancer Center at University Hospital
Cincinnati, Ohio, 45267, United States
Case Comprehensive Cancer Center
Cleveland, Ohio, 44106-5065, United States
MetroHealth Cancer Care Center at MetroHealth Medical Center
Cleveland, Ohio, 44109, United States
North Coast Cancer Care - Clyde
Clyde, Ohio, 43410, United States
Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210-1240, United States
Riverside Methodist Hospital Cancer Care
Columbus, Ohio, 43214-3998, United States
CCOP - Columbus
Columbus, Ohio, 43215, United States
Grant Medical Center Cancer Care
Columbus, Ohio, 43215, United States
Mount Carmel Health - West Hospital
Columbus, Ohio, 43222, United States
Doctors Hospital at Ohio Health
Columbus, Ohio, 43228, United States
Dayton Children's - Dayton
Dayton, Ohio, 45404, United States
Grandview Hospital
Dayton, Ohio, 45405, United States
Good Samaritan Hospital
Dayton, Ohio, 45406, United States
David L. Rike Cancer Center at Miami Valley Hospital
Dayton, Ohio, 45409, United States
Samaritan North Cancer Care Center
Dayton, Ohio, 45415, United States
CCOP - Dayton
Dayton, Ohio, 45420, United States
Grady Memorial Hospital
Delaware, Ohio, 43015, United States
Community Cancer Center
Elyria, Ohio, 44035, United States
Hematology Oncology Center
Elyria, Ohio, 44035, United States
Blanchard Valley Medical Associates
Findlay, Ohio, 45840, United States
Middletown Regional Hospital
Franklin, Ohio, 45005-1066, United States
Wayne Hospital
Greenville, Ohio, 45331, United States
Charles F. Kettering Memorial Hospital
Kettering, Ohio, 45429, United States
Fairfield Medical Center
Lancaster, Ohio, 43130, United States
St. Rita's Medical Center
Lima, Ohio, 45801, United States
Lima Memorial Hospital
Lima, Ohio, 45804, United States
Strecker Cancer Center at Marietta Memorial Hospital
Marietta, Ohio, 45750, United States
Northwest Ohio Oncology Center
Maumee, Ohio, 43537-1839, United States
St. Luke's Hospital
Maumee, Ohio, 43537, United States
Knox Community Hospital
Mount Vernon, Ohio, 43050, United States
Licking Memorial Cancer Care Program at Licking Memorial Hospital
Newark, Ohio, 43055, United States
Fisher-Titus Medical Center
Norwalk, Ohio, 44857, United States
St. Charles Mercy Hospital
Oregon, Ohio, 43616, United States
Toledo Clinic - Oregon
Oregon, Ohio, 43616, United States
North Coast Cancer Care, Incorporated
Sandusky, Ohio, 44870, United States
Community Hospital of Springfield and Clark County
Springfield, Ohio, 45505, United States
Flower Hospital Cancer Center
Sylvania, Ohio, 43560, United States
Mercy Hospital of Tiffin
Tiffin, Ohio, 44883, United States
Toledo Hospital
Toledo, Ohio, 43606, United States
St. Vincent Mercy Medical Center
Toledo, Ohio, 43608, United States
Medical University of Ohio Cancer Center
Toledo, Ohio, 43614, United States
CCOP - Toledo Community Hospital
Toledo, Ohio, 43617, United States
St. Anne Mercy Hospital
Toledo, Ohio, 43623, United States
Toledo Clinic, Incorporated - Main Clinic
Toledo, Ohio, 43623, United States
UVMC Cancer Care Center at Upper Valley Medical Center
Troy, Ohio, 45373-1300, United States
Fulton County Health Center
Wauseon, Ohio, 43567, United States
Mount Carmel St. Ann's Cancer Center
Westerville, Ohio, 43081, United States
Clinton Memorial Hospital
Wilmington, Ohio, 45177, United States
Ruth G. McMillan Cancer Center at Greene Memorial Hospital
Xenia, Ohio, 45385, United States
Genesis - Good Samaritan Hospital
Zanesville, Ohio, 43701, United States
Cleo Craig Cancer Research Clinic
Lawton, Oklahoma, 73505, United States
Oklahoma University Cancer Institute
Oklahoma City, Oklahoma, 73104, United States
Cancer Care Associates - Mercy Campus
Oklahoma City, Oklahoma, 73120, United States
Legacy Mount Hood Medical Center
Gresham, Oregon, 97030, United States
Providence Milwaukie Hospital
Milwaukie, Oregon, 97222, United States
Legacy Good Samaritan Hospital & Comprehensive Cancer Center
Portland, Oregon, 97210, United States
Providence Cancer Center at Providence Portland Medical Center
Portland, Oregon, 97213-2967, United States
Adventist Medical Center
Portland, Oregon, 97216, United States
CCOP - Columbia River Oncology Program
Portland, Oregon, 97225, United States
Providence St. Vincent Medical Center
Portland, Oregon, 97225, United States
Legacy Emanuel Hospital and Health Center and Children's Hospital
Portland, Oregon, 97227, United States
Northwest Cancer Specialists at Rose Quarter Cancer Center
Portland, Oregon, 97227, United States
Salem Hospital Regional Cancer Care Services
Salem, Oregon, 97309-5014, United States
Legacy Meridian Park Hospital
Tualatin, Oregon, 97062, United States
Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest
Allentown, Pennsylvania, 18105, United States
St. Luke's Cancer Network at St. Luke's Hospital
Bethlehem, Pennsylvania, 18015, United States
Lehigh Valley Hospital - Muhlenberg
Bethlehem, Pennsylvania, 18017, United States
Geisinger Cancer Institute at Geisinger Health
Danville, Pennsylvania, 17822-0001, United States
Geisinger Hazleton Cancer Center
Hazleton, Pennsylvania, 18201, United States
Penn State Children's Hospital
Hershey, Pennsylvania, 17033-0850, United States
Penn State Hershey Cancer Institute at Milton S. Hershey Medical Center
Hershey, Pennsylvania, 17033-0850, United States
Lancaster General Hospital
Lancaster, Pennsylvania, 17604, United States
Lewistown Hospital
Lewistown, Pennsylvania, 17044, United States
Abramson Cancer Center of the University of Pennsylvania
Philadelphia, Pennsylvania, 19104-4283, United States
Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
Philadelphia, Pennsylvania, 19107-5541, United States
St. Christopher's Hospital for Children
Philadelphia, Pennsylvania, 19134-1095, United States
Allegheny Cancer Center at Allegheny General Hospital
Pittsburgh, Pennsylvania, 15212, United States
UPMC Cancer Centers
Pittsburgh, Pennsylvania, 15232, United States
McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center
Reading, Pennsylvania, 19612-6052, United States
Guthrie Cancer Center at Guthrie Clinic Sayre
Sayre, Pennsylvania, 18840, United States
Mercy Hospital Cancer Center - Scranton
Scranton, Pennsylvania, 18501, United States
Hematology and Oncology Associates of Northeastern Pennsylvania
Scranton, Pennsylvania, 18510, United States
Geisinger Medical Group - Scenery Park
State College, Pennsylvania, 16801, United States
Mount Nittany Medical Center
State College, Pennsylvania, 16803, United States
Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center
Wilkes-Barre, Pennsylvania, 18711, United States
Susquehanna Cancer Center at Divine Providence Hospital
Williamsport, Pennsylvania, 17701, United States
York Cancer Center at Apple Hill Medical Center
York, Pennsylvania, 17405, United States
Rapid City Regional Hospital
Rapid City, South Dakota, 57701, United States
Avera Cancer Institute
Sioux Falls, South Dakota, 57105, United States
Medical X-Ray Center, PC
Sioux Falls, South Dakota, 57105, United States
Sanford Cancer Center at Sanford USD Medical Center
Sioux Falls, South Dakota, 57117-5039, United States
Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center
Kingsport, Tennessee, 37662, United States
East Tennessee Children's Hospital
Knoxville, Tennessee, 37901, United States
Center for Biomedical Research
Knoxville, Tennessee, 37909, United States
Vanderbilt-Ingram Cancer Center
Nashville, Tennessee, 37232-6838, United States
Harrington Cancer Center
Amarillo, Texas, 79106, United States
Medical City Dallas Hospital
Dallas, Texas, 75230, United States
University of Texas Health Science Center at San Antonio
San Antonio, Texas, 78207, United States
Methodist Children's Hospital of South Texas
San Antonio, Texas, 78229-3993, United States
CCOP - Scott and White Hospital
Temple, Texas, 76508, United States
American Fork Hospital
American Fork, Utah, 84003, United States
Sandra L. Maxwell Cancer Center
Cedar City, Utah, 84720, United States
Logan Regional Hospital
Logan, Utah, 84321, United States
Jon and Karen Huntsman Cancer Center at Intermountain Medical Center
Murray, Utah, 84157, United States
Val and Ann Browning Cancer Center at McKay-Dee Hospital Center
Ogden, Utah, 84403, United States
Utah Valley Regional Medical Center - Provo
Provo, Utah, 84604, United States
LDS Hospital
Salt Lake City, Utah, 84103, United States
Utah Cancer Specialists at UCS Cancer Center
Salt Lake City, Utah, 84106, United States
Huntsman Cancer Institute at University of Utah
Salt Lake City, Utah, 84112, United States
Dixie Regional Medical Center - East Campus
St. George, Utah, 84770, United States
University of Virginia Cancer Center
Charlottesville, Virginia, 22908, United States
Danville Regional Medical Center
Danville, Virginia, 24541, United States
Fredericksburg Oncology, Incorporated
Fredericksburg, Virginia, 22401, United States
Southwest Virginia Regional Cancer Center at Wellmonth Health
Norton, Virginia, 24273, United States
St. Joseph Cancer Center
Bellingham, Washington, 98225, United States
Olympic Hematology and Oncology
Bremerton, Washington, 98310, United States
Providence Centralia Hospital
Centralia, Washington, 98531-9027, United States
St. Francis Hospital
Federal Way, Washington, 98003, United States
Columbia Basin Hematology
Kennewick, Washington, 99336, United States
Skagit Valley Hospital Cancer Care Center
Mount Vernon, Washington, 98273, United States
Providence St. Peter Hospital Regional Cancer Center
Olympia, Washington, 98506-5166, United States
Harrison Poulsbo Hematology and Onocology
Poulsbo, Washington, 98370, United States
Good Samaritan Cancer Center
Puyallup, Washington, 98372, United States
Minor and James Medical, PLLC
Seattle, Washington, 98104, United States
Group Health Central Hospital
Seattle, Washington, 98112, United States
Swedish Cancer Institute at Swedish Medical Center - First Hill Campus
Seattle, Washington, 98122-4307, United States
Polyclinic First Hill
Seattle, Washington, 98122, United States
University Cancer Center at University of Washington Medical Center
Seattle, Washington, 98195, United States
Cancer Care Northwest - Spokane South
Spokane, Washington, 99202, United States
Evergreen Hematology and Oncology, PS
Spokane, Washington, 99218, United States
Franciscan Cancer Center at St. Joseph Medical Center
Tacoma, Washington, 98405-3004, United States
Allenmore Hospital
Tacoma, Washington, 98405, United States
CCOP - Northwest
Tacoma, Washington, 98405, United States
MultiCare Regional Cancer Center at Tacoma General Hospital
Tacoma, Washington, 98405, United States
St. Clare Hospital
Tacoma, Washington, 98499, United States
Southwest Washington Medical Center Cancer Center
Vancouver, Washington, 98668, United States
Legacy Salmon Creek Medical Center
Vancouver, Washington, 98686, United States
Wenatchee Valley Medical Center
Wenatchee, Washington, 98801-2028, United States
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
Yakima, Washington, 98902, United States
West Virginia University Health Sciences Center - Charleston
Charleston, West Virginia, 25302, United States
Edwards Comprehensive Cancer Center at Cabell Huntington Hospital
Huntington, West Virginia, 25701, United States
Mary Babb Randolph Cancer Center at West Virginia University Hospitals
Morgantown, West Virginia, 26506, United States
Community Comprehensive Cancer Center at Camden-Clark Memorial Hospital
Parkersburg, West Virginia, 26102, United States
Schiffler Cancer Center at Wheeling Hospital
Wheeling, West Virginia, 26003, United States
Fox Valley Hematology and Oncology - East Grant Street
Appleton, Wisconsin, 54911-3496, United States
Aurora Memorial Hospital of Burlington
Burlington, Wisconsin, 53105, United States
Marshfield Clinic - Chippewa Center
Chippewa Falls, Wisconsin, 54729, United States
Center for Cancer Treatment & Prevention at Sacred Heart Hospital
Eau Claire, Wisconsin, 54701, United States
Marshfield Clinic Cancer Care at Regional Cancer Center
Eau Claire, Wisconsin, 54701, United States
Vince Lombardi Cancer Center at Aurora Lakeland Medical Center - Elkhorn
Elkhorn, Wisconsin, 53121, United States
Oncology Alliance - Franklin
Franklin, Wisconsin, 53132, United States
Oncology Alliance, SC - Milwaukee - East
Glendale, Wisconsin, 53212-1038, United States
Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center
Green Bay, Wisconsin, 54301-3526, United States
Green Bay Oncology, Limited at St. Mary's Hospital
Green Bay, Wisconsin, 54303, United States
St. Mary's Hospital Medical Center - Green Bay
Green Bay, Wisconsin, 54303, United States
St. Vincent Hospital Regional Cancer Center
Green Bay, Wisconsin, 54307-3508, United States
Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center
Green Bay, Wisconsin, 54311, United States
UW Cancer Center Johnson Creek
Johnson Creek, Wisconsin, 53038, United States
Oncology Alliance - Kenosha South
Kenosha, Wisconsin, 53143, United States
Gundersen Lutheran Center for Cancer and Blood
La Crosse, Wisconsin, 54601, United States
Dean Medical Center - Madison
Madison, Wisconsin, 53717, United States
University of Wisconsin Paul P. Carbone Comprehensive Cancer Center
Madison, Wisconsin, 53792-6164, United States
Holy Family Memorial Medical Center Cancer Care Center
Manitowoc, Wisconsin, 54221-1450, United States
Bay Area Cancer Care Center at Bay Area Medical Center
Marinette, Wisconsin, 54143, United States
Vince Lombardi Cancer Clinic - Marinette
Marinette, Wisconsin, 54143, United States
Marshfield Clinic - Marshfield Center
Marshfield, Wisconsin, 54449, United States
Saint Joseph's Hospital
Marshfield, Wisconsin, 54449, United States
Aurora Advanced Healthcare East Mequon Clinic
Mequon, Wisconsin, 53092, United States
Medical Consultants, Limited
Milwaukee, Wisconsin, 53215, United States
Oncology Alliance, SC - Milwaukee - South
Milwaukee, Wisconsin, 53215, United States
Medical College of Wisconsin Cancer Center
Milwaukee, Wisconsin, 53226, United States
Marshfield Clinic - Lakeland Center
Minocqua, Wisconsin, 54548, United States
Green Bay Oncology, Limited - Oconto Falls
Oconto Falls, Wisconsin, 54154, United States
Aurora Health Center - Racine
Racine, Wisconsin, 53406-5661, United States
Ministry Medical Group at Saint Mary's Hospital
Rhinelander, Wisconsin, 54501, United States
Marshfield Clinic - Indianhead Center
Rice Lake, Wisconsin, 54868, United States
Vince Lombardi Cancer Clinic - Sheboygan
Sheboygan, Wisconsin, 53081, United States
Marshfield Clinic at Saint Michael's Hospital
Stevens Point, Wisconsin, 54481, United States
Saint Michael's Hospital Cancer Center
Stevens Point, Wisconsin, 54481, United States
Green Bay Oncology, Limited - Sturgeon Bay
Sturgeon Bay, Wisconsin, 54235, United States
Aurora Medical Center
Summit, Wisconsin, 53066, United States
Vince Lombardi Cancer Clinic - Two Rivers
Two Rivers, Wisconsin, 54241, United States
Aurora Health Center - Waukesha
Waukesha, Wisconsin, 53188, United States
Marshfield Clinic - Wausau Center
Wausau, Wisconsin, 54401, United States
Oncology Alliance, SC - Milwaukee - West
Wauwatosa, Wisconsin, 53226, United States
Diagnostic and Treatment Center
Weston, Wisconsin, 54476, United States
Marshfield Clinic - Weston Center
Weston, Wisconsin, 54476, United States
Marshfield Clinic - Wisconsin Rapids Center
Wisconsin Rapids, Wisconsin, 54494, United States
Rocky Mountain Oncology
Casper, Wyoming, 82609, United States
Welch Cancer Center at Sheridan Memorial Hospital
Sheridan, Wyoming, 82801, United States
Westmead Institute for Cancer Research at Westmead Hospital
Westmead, New South Wales, 2145, Australia
Cross Cancer Institute at University of Alberta
Edmonton, Alberta, T6G 1Z2, Canada
British Columbia Cancer Agency - Centre for the Southern Interior
Kelowna, British Columbia, V1Y 5L3, Canada
BCCA - Fraser Valley Cancer Centre
Surrey, British Columbia, V3V 1Z2, Canada
British Columbia Cancer Agency - Vancouver Cancer Centre
Vancouver, British Columbia, V5Z 4E6, Canada
British Columbia Cancer Agency - Vancouver Island Centre
Victoria, British Columbia, V8R 6V5, Canada
CancerCare Manitoba
Winnipeg, Manitoba, R3E 0V9, Canada
Nova Scotia Cancer Centre
Halifax, Nova Scotia, B3H 1V7, Canada
Royal Victoria Hospital of Barrie
Barrie, Ontario, L4M 6M2, Canada
Margaret and Charles Juravinski Cancer Centre
Hamilton, Ontario, L8V 5C2, Canada
London Regional Cancer Program at London Health Sciences Centre
London, Ontario, N6A 4L6, Canada
R. S. McLaughlin Durham Regional Cancer Centre at Lakeridge Health Oshawa
Oshawa, Ontario, L1G 2B9, Canada
St. Catharines General Hospital at Niagara Health System
St. Catharines, Ontario, L2R 7C6, Canada
Edmond Odette Cancer Centre at Sunnybrook
Toronto, Ontario, M4N 3M5, Canada
Princess Margaret Hospital
Toronto, Ontario, M5G 2M9, Canada
Trillium Health Centre - Mississauga Site
Toronto, Ontario, M9C 1A5, Canada
Windsor Regional Cancer Centre at Windsor Regional Hospital
Windsor, Ontario, N8W 2X3, Canada
Hopital Notre-Dame du CHUM
Montreal, Quebec, H2L 4M1, Canada
McGill Cancer Centre at McGill University
Montreal, Quebec, H2W 1S6, Canada
CHUM - Hotel Dieu Hospital
Montreal, Quebec, H2W 1T8, Canada
Allan Blair Cancer Centre at Pasqua Hospital
Regina, Saskatchewan, S4T 7T1, Canada
Pretoria Academic Hospital
Pretoria, 0002, South Africa
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Results Point of Contact
- Title
- Study statistician
- Organization
- ECOG-ACRIN Statistical Office
Study Officials
- STUDY CHAIR
Sanjiv S. Agarwala, MD
St. Luke's Cancer Network at St. Luke's Hospital
- STUDY CHAIR
John M. Kirkwood, MD
UPMC Cancer Center at UPMC Presbyterian
- STUDY CHAIR
Lawrence E. Flaherty, MD
Barbara Ann Karmanos Cancer Institute
- STUDY CHAIR
William E. Carson, MD
Ohio State University Comprehensive Cancer Center
- STUDY CHAIR
Michael Smylie, MD, MB, ChB
Cross Cancer Institute at University of Alberta
- PRINCIPAL INVESTIGATOR
Alberto S. Pappo, MD
Texas Children's Cancer Center
Publication Agreements
- PI is Sponsor Employee
- No
- Restriction Type
- LTE60
- Restrictive Agreement
- Yes
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- NETWORK
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
November 1, 1999
First Posted
January 27, 2003
Study Start
March 25, 1999
Primary Completion
January 1, 2015
Study Completion (Estimated)
December 1, 2026
Last Updated
February 25, 2026
Results First Posted
May 4, 2016
Record last verified: 2026-02
Data Sharing
- IPD Sharing
- Will share
Individual participant data may be made available upon request as per the ECOG-ACRIN Data Sharing Policy