NCT00001551

Brief Summary

According to studies, speech disorders with unknown causes (idiopathic) affect approximately 5% of the population at some point in their life. Some of these disorders like, stuttering and cluttering, are known for being detected early, during speech development. Stuttering is characterized by sound and syllable repetitions and consonant/vowel prolongations. When stuttering is moderate to severe, it can interfere with a person's job and social activities. Speech articulation disorders are characterized by omissions, or substitutions of speech sounds. The speech of a person who clutters is often difficult to understand. People are often unaware of the errors they make when speaking causing treatment of the condition to be very difficult. The purpose of this research is to study an extended family whose members exhibit a pure form of speech articulation disorders In addition, the study will use data and information gathered from the study and use it to develop guidelines (criteria) for defining and differentiating patients with speech disorders.

Trial Health

80
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
375

participants targeted

Target at P75+ for all trials

Geographic Reach
1 country

2 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 22, 1996

Completed
3.5 years until next milestone

First Submitted

Initial submission to the registry

November 3, 1999

Completed
1 day until next milestone

First Posted

Study publicly available on registry

November 4, 1999

Completed
10 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 13, 2009

Completed
Last Updated

July 2, 2017

Status Verified

November 13, 2009

Enrollment Period

13.5 years

First QC Date

November 3, 1999

Last Update Submit

June 30, 2017

Conditions

Developmental Articulation DisorderSpeech DisorderStuttering

Keywords

StutteringLinkagePedigreeSpeech ArticulationPhonological Processing DisordersSpeech Disorder

Eligibility Criteria

Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • i. Normal Language Development, Hearing and Cognition
  • ii. The following screening tests previously published with norms were found to have a good distribution for determining normal functioning in adolescents and adults as all subjects did not hit ceiling and all had scores greater than or equal to the 80th percentile. These tests are being used to ensure that subjects affected with stuttering or FPPD do not have other disorders such as hearing loss, language delay, or mental retardation.
  • Peabody Picture Vocabulary Test III (PPVT-III)
  • Expressive Vocabulary Test (EVT)
  • Oral Speech Mechanism Screening Examination
  • Revised Token Test; Token test for Children
  • Test of Non verbal intelligence (TONI-2)
  • Digit Span subtest of the WICS-R
  • Audiometric Screening
  • Goldman Fristoe Test of Articulation
  • WUG Test of Morphological Encoding
  • Test of Auditory Comprehension of Language (TACL)
  • Khan-Lewis Phonological Analysis
  • i. A total overall score of 11 or greater between 3 and 17 years,
  • ii. A total overall score of 18 or greater from age 18 and above.
  • +5 more criteria

You may not qualify if:

  • i. Anyone with a hearing loss will be excluded from participation during the diagnostic testing.
  • ii. Children with delayed language, more than 1 year delay from norms on receptive and expression language testing will be excluded.
  • v. Bilingual non-native English speakers - Studies have demonstrated that brain organization for speech and language may differ in bilingual persons. It is hypothesized that this may alter speech motor learning and thus kinematic data from non-native English speakers would differ from native English speakers. Therefore, only native-American English speakers, with only one language spoken in the home, will be included.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

University of Maryland, College Park

College Park, Maryland, United States

Location

University of Wisconsin

Madison, Wisconsin, 53792, United States

Location

Related Publications (3)

  • Plomin R, Owen MJ, McGuffin P. The genetic basis of complex human behaviors. Science. 1994 Jun 17;264(5166):1733-9. doi: 10.1126/science.8209254.

    PMID: 8209254BACKGROUND

  • Cox NJ, Seider RA, Kidd KK. Some environmental factors and hypotheses for stuttering in families with several stutterers. J Speech Hear Res. 1984 Dec;27(4):543-8. doi: 10.1044/jshr.2704.543.

    PMID: 6521460BACKGROUND

  • Felsenfeld S, McGue M, Broen PA. Familial aggregation of phonological disorders: results from a 28-year follow-up. J Speech Hear Res. 1995 Oct;38(5):1091-107. doi: 10.1044/jshr.3805.1091.

    PMID: 8558878BACKGROUND

MeSH Terms

Conditions

Articulation DisordersSpeech DisordersStuttering

Condition Hierarchy (Ancestors)

Language DisordersCommunication DisordersNeurobehavioral ManifestationsNeurologic ManifestationsNervous System DiseasesSigns and SymptomsPathological Conditions, Signs and Symptoms

Study Design

Study Type
observational
Sponsor Type
NIH

Study Record Dates

First Submitted

November 3, 1999

First Posted

November 4, 1999

Study Start

May 22, 1996

Primary Completion

November 13, 2009

Last Updated

July 2, 2017

Record last verified: 2009-11-13

Locations

US(2)