Activity of the Auditory Cortex During Speech Perception and Speech Production in Stuttering

NCT00148161 | Unknown

• 1 other identifier: phonpaed001
• Study Type: observational
• Target: 20
• Locations: 1 country
• Sites: 2

Brief Summary

The goal of the study is to examine the cortical activity during speech perception and speech production in idiopathic stutterers compared to fluent speakers. Therefore, the noninvasive method of magnetoencephalography (MEG) is used. A better understanding for the complexity of speech perception and its pathology should be developed. Fundamental properties of stuttering are repetitions, prolongations, and blocks. In most cases stuttering emerges between 2 and 5 years of age. The auditory feedback should become less important during development, as soon as information about mispronounced words does not occur anymore. During speech development this control function should be adopted by other systems. In stutterers the dominance of the acoustic control should remain. Brain imaging studies with positron emission tomography (PET) or magnetic resonance imaging (MRI) show defects in the network of motor system, in the lateralization of speech areas, and functions of the auditory cortex. Magnetoencephalographic studies describe a similar variety as cause of stuttering. There may be defects in the auditory feedback, a modification of the lateralization of speech areas, or an alteration of co-action of motor planning and auditory system. The benefit of magnetoencephalography is a very good temporal resolution in the range of milliseconds combined with good spatial resolution. Therefore, it is well suited to examine the dynamics of cortical processing during stuttering. In this study evoked components of the auditory systems related to complex sounds, vocals, consonant-vocal combinations, and single words are analyzed. Differences of these components in the auditory cortices of stutterers and fluent speakers are hypothesized as well in temporal structure as in localization and lateralization.

Conditions

Stuttering

Keywords

Magnetoencephalography; Auditory cortex; Stuttering; Non stuttering

Eligibility Criteria

• Age: 18 Years+
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Subjects with idiopathic stuttering (for the group of stutterers)
• Fluently speaking subjects (for the control group)
• Right handed
• Normal hearing

You may not qualify if:

• Neurological diseases
• Psychiatric diseases
• Medication with neurological effective drugs
• Implants with magnetic impact

Sponsors & Collaborators

• University Hospital Muenster: lead

Study Sites (2)

Institute for Biomagnetism and Biosignalanalysis

Münster, 48149, Germany

RECRUITING

Department of Phoniatrics and Pediatric Audiology, University Hospital Münster

Münster, 48161, Germany

RECRUITING

Related Links

• Homepage of the Institute for Biomagnetism and Biosignalanalysis

MeSH Terms

Conditions

Stuttering

Condition Hierarchy (Ancestors)

Speech Disorders; Language Disorders; Communication Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Antoinette G Dinnesen, Prof. Dr.

  Department of Phoniatrics and Pediatric Audiology, University Hospital Münster

  STUDY DIRECTOR

• Arne Knief, Dr.

  Department of Phoniatrics and Pediatric Audiology, University Hospital Münster

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Antoinette G Dinnesen, Prof. Dr.

CONTACT

+49(0)251 83; a.g.dinnesen@uni-muenster.de

Arne Knief, Dr.

CONTACT

+49(0)251 83; knief@uni-muenster.de

Study Design

• Study Type: observational
• Observational Model: DEFINED POPULATION
• Time Perspective: OTHER
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: September 6, 2005
• First Posted: September 7, 2005
• Study Start: November 1, 2004
• Last Updated: April 27, 2007

Record last verified: 2006-09

Locations

DE (2)