NCT00004991|Completed
Study of Brain Activity During Speech Production and Speech Perception
Brain Activation During Developmental Speech Production and Speech Perception
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Brain Activation During Developmental Speech Production and Speech Perception
Sponsor study identifier
Secondary identifiers
observational
411
1 country
1
Study Start
March 14, 2000
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
August 31, 2009
Actual (reported)Study Completion
Not reported
Date not reportedThe purpose of this study is to gain a better understanding of the brain's activity and organization in the development of speech disorders. It will compare brain activity in people with normal speech development with those who stutter or who have a phonological disorder (a deficit in how the brain processes speech sounds). Stuttering and phonological disorders emerge during the critical period of speech development between 2.5 and 12 years of age. During this period, the brain is much more adaptable for speech development than it is after puberty. This study will examine how the brain organization for speech production and perception develops normally during the critical period and how the normal pattern is altered when stuttering and phonological disorders become chronic problems, persisting throughout life. Volunteer adults and children with and without speech disorders may participate in this study. Eligibility screening will include a brief neurological and physical examination and tests to determine normal speech or a speech disorder. The speech testing will be videotaped. The subject will speak aloud, describe pictures, recall words or numbers, imitate speech sounds and words, and perform some listening tests. Study participants will undergo magnetic resonance imaging (MRI) to study brain activity. For this procedure, the subject lies on a stretcher that is moved into a donut-shaped machine with a strong magnetic field. During the MRI scan, the subject will perform simple tasks, such as listening to speech or other sounds and saying nonsense words. The procedure should take less than 60 minutes, and usually takes from 20 to 40 minutes.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
Not reported
Date not reportedClick on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
March 14, 2000
Date type not reportedThis date has not been verified as actual or estimated.
March 18, 2000
Actual (reported)March 20, 2000
Actual (reported)August 31, 2009
Actual (reported)National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, 20892, United States
Wise R, Chollet F, Hadar U, Friston K, Hoffner E, Frackowiak R. Distribution of cortical neural networks involved in word comprehension and word retrieval. Brain. 1991 Aug;114 ( Pt 4):1803-17. doi: 10.1093/brain/114.4.1803.
Klein D, Milner B, Zatorre RJ, Meyer E, Evans AC. The neural substrates underlying word generation: a bilingual functional-imaging study. Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2899-903. doi: 10.1073/pnas.92.7.2899.
First Submitted
March 18, 2000
First Posted
March 20, 2000
Study Start
March 14, 2000
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
August 31, 2009
Actual (reported)Effects of Psilocybin on Speech Fluency, Struggle, and Brain Activity in People Who Stutter
Contact the study team to confirm eligibility.
Muller RA, Behen ME, Rothermel RD, Muzik O, Chakraborty PK, Chugani HT. Brain organization for language in children, adolescents, and adults with left hemisphere lesion: a PET study. Prog Neuropsychopharmacol Biol Psychiatry. 1999 May;23(4):657-68. doi: 10.1016/s0278-5846(99)00024-x.
Last Updated
July 2, 2017
Record last verified: 2009-08-31
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Source: ClinicalTrials.gov.
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