Influence of Diet and Endurance Running on Intramuscular Lipids Measured at 4.1 TESLA

NCT00000110 | Completed

• 2 other identifiers: NCRR-M01RR00032-0855M01RR000032
• Study Type: interventional
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this pilot investigation is to use 1 H Magnetic Resonance Spectroscopy (MRS) to 1) document the change in intra-muscular lipid stores (IML) before and after a prolonged bout of endurance running and, 2) determine the pattern (time course) of IML replenishment following an extremely low-fat diet (10% of energy from fat) and a moderate-fat diet (35% of energy from fat). Specifically, the study will evaluate the change in IML following a 2-hour training run and the recovery of IML in response to the post-exercise low-fat or moderate-fat diet in 10 endurance trained athletes who will consume both diets in a randomly assigned cross-over fashion. We hypothesize that IML will be depleted with prolonged endurance exercise, and that replenishment of IML will be impaired by an extremely low-fat diet compared to a moderate-fat diet. Results of this pilot study will be used to apply for extramural grant support from NIH or the US Armed Forces to investigate the effect of dietary fat on the health and performance of individuals performing heavy physical training. It is anticipated that this methodology could also be employed in obesity research to delineate, longitudinally, the reported cross-sectional relationships among IML stores, insulin resistance and obesity.

Conditions

Obesity

Keywords

exercise; exertion; physical fitness; lipids; nutrition

Interventions

magnetic resonance spectroscopy PROCEDURE

dietary fat DRUG

Eligibility Criteria

• Age: 18 Years - 49 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy volunteers (developmental phase)
• Healthy endurance-trained subjects
• Maximum age for males is 39
• Maximum age for females is 49

Sponsors & Collaborators

• National Center for Research Resources (NCRR): lead

Study Sites (1)

The University of Alabama at Birmingham Nutrition Sciences Department

Birmingham, Alabama, 35294, United States

Location

MeSH Terms

Conditions

Obesity; Motor Activity

Interventions

Magnetic Resonance Spectroscopy; Dietary Fats

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Behavior

Intervention Hierarchy (Ancestors)

Spectrum Analysis; Chemistry Techniques, Analytical; Investigative Techniques; Fats; Lipids; Food; Diet, Food, and Nutrition; Physiological Phenomena; Food and Beverages

Study Design

• Study Type: interventional
• Phase: not applicable
• Masking: SINGLE
• Purpose: TREATMENT
• Sponsor Type: NIH

Study Record Dates

• First Submitted: January 18, 2000
• First Posted: January 19, 2000
• Last Updated: June 24, 2005

Record last verified: 2003-12

Locations

US (1)