Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

Low Risk

Score: 25/100

Failure Rate

8.7%

34 terminated/withdrawn out of 390 trials

Success Rate

89.1%

+2.6% vs industry average

Late-Stage Pipeline

28%

108 trials in Phase 3/4

Results Transparency

51%

143 of 279 completed trials have results

Key Signals

23 recruiting143 with results26 terminated8 withdrawn

Enrollment Performance

Analytics

Phase 1
139(43.0%)
Phase 2
61(18.9%)
Phase 3
58(18.0%)
Phase 4
50(15.5%)
N/A
14(4.3%)
Early Phase 1
1(0.3%)
323Total
Phase 1(139)
Phase 2(61)
Phase 3(58)
Phase 4(50)
+2 more

Activity Timeline

Global Presence

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Clinical Trials (390)

Showing 20 of 390 trials
NCT06451341Active Not Recruiting

IMplementation of CAB+RPV LA for People With HIV in Non-Metropolitan Areas

Role: collaborator

NCT04133012Not ApplicableCompleted

Cartography of Virologic Reservoir Related to Antiretroviral Concentrations in HIV-1 Chronic Patients Treated by a First Line Treatment Containing Dolutegravir and Associated Nucleoside / Nucleotide Reverse Transcriptase Inhibitors Backbone

Role: collaborator

NCT06444620Phase 3Active Not Recruiting

B/F/TAF to DTG/3TC Switch Study

Role: collaborator

NCT07525544Phase 1Not Yet Recruiting

A Study to Investigate the Safety and PK of VH4770359 in Healthy Participants

Role: lead

NCT01420523Phase 2Terminated

Evaluation of Raltegravir Plus Maraviroc Therapy in Controlled HIV Patients Presenting With Lipohypertrophy

Role: collaborator

NCT07053384Phase 1Active Not Recruiting

A Study to Investigate the Use of VH3810109 With or Without Fostemsavir (FTR) to Reduce the Size and Activity of the Viral Reservoir in People Living With HIV

Role: lead

NCT07199335Phase 4Recruiting

Long-acting Cabotegravir Injectable Pre-exposure Prophylaxis for People Who Inject Drugs

Role: collaborator

NCT02938520Phase 3Active Not Recruiting

Study to Evaluate the Efficacy, Safety, and Tolerability of Long-acting Intramuscular Cabotegravir and Rilpivirine for Maintenance of Virologic Suppression Following Switch From an Integrase Inhibitor in HIV-1 Infected Therapy Naive Participants

Role: lead

NCT02720094Phase 2Completed

Injectable Cabotegravir Compared to TDF/FTC For PrEP in HIV-Uninfected Men and Transgender Women Who Have Sex With Men

Role: collaborator

NCT06310551Phase 1Recruiting

First Time in Human Study of Long Acting VH4524184 Formulations

Role: lead

NCT06900829Not ApplicableRecruiting

#AWARE.HIV Europe: Supporting Healthcare Professionals to Find Undiagnosed HIV in European Hospitals: An Effectiveness-implementation Trial.

Role: collaborator

NCT07202546Phase 2Recruiting

A Phase 2b Study Evaluating Oral VH4524184 Regimens in Treatment Naïve Persons With HIV-1 (INNOVATE Study)

Role: lead

NCT05996471Phase 2Active Not Recruiting

A Study to Investigate the Virologic Efficacy and Safety of VH3810109 + Cabotegravir Compared to Standard of Care (SOC) in Male and Female Adults Living With Human Immunodeficiency Virus (HIV)

Role: lead

NCT07066722Phase 1Completed

A Study to Evaluate VH4524184 Tablet Absorption, Effects of Food, and Interactions With Other Drugs in Healthy Adults

Role: lead

NCT05917509Phase 3Active Not Recruiting

A Study to Evaluate the Efficacy, Safety, Participant Choice and Preference of an Oral Once-daily Regimen or a Long-acting Injectable Regimen Every Two Months for Treatment of Human Immunodeficiency Virus (HIV-1) in Adults Who Have Not Previously Taken Antiretroviral Therapy

Role: lead

NCT06694805Phase 3Recruiting

A Study to Evaluate the Effectiveness of Long-acting (LA) Cabotegravir (CAB) + Rilpivirine (RPV) LA When Given to Participants With Detectable HIV-1

Role: lead

NCT06652958Phase 1Active Not Recruiting

A Study to Assess the Safety and Pharmacokinetics of a Human Monoclonal Antibody (VH4527079) in Healthy Adults and Persons With HIV

Role: lead

NCT04648280Phase 1Active Not Recruiting

Safety and Pharmacokinetics Evaluation of Fostemsavir + (OBT) in HIV-1 Infected Children and Adolescents Who Are Failing Their cART and Have Dual- or Triple-class Antiretroviral Resistance

Role: collaborator

NCT05986084Phase 4Active Not Recruiting

Tshireletso: Safety, Efficacy and Feasibility of Cabotegravir-LA PrEP in a Breastfeeding Population in Botswana

Role: collaborator

NCT05514509Phase 4Completed

A Study Evaluating Implementation Strategies for the Delivery of APRETUDE for Black cis-and Transgender Women in United States EHE Territories

Role: lead