Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

Low Risk

Score: 25/100

Failure Rate

8.6%

34 terminated/withdrawn out of 395 trials

Success Rate

89.2%

+2.7% vs industry average

Late-Stage Pipeline

28%

111 trials in Phase 3/4

Results Transparency

52%

147 of 281 completed trials have results

Key Signals

25 recruiting147 with results26 terminated8 withdrawn

Enrollment Performance

Analytics

Phase 1
140(42.7%)
Phase 2
62(18.9%)
Phase 3
60(18.3%)
Phase 4
51(15.5%)
N/A
14(4.3%)
Early Phase 1
1(0.3%)
328Total
Phase 1(140)
Phase 2(62)
Phase 3(60)
Phase 4(51)
+2 more

Activity Timeline

Global Presence

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Clinical Trials (395)

Showing 20 of 395 trials
NCT05986084Phase 4Active Not Recruiting

Tshireletso: Safety, Efficacy and Feasibility of Cabotegravir-LA PrEP in a Breastfeeding Population in Botswana

Role: collaborator

NCT06134362Phase 3Active Not Recruiting

Long-term Follow-up of Long-acting Cabotegravir (CAB LA) for PrEP (Pre-exposure Prophylaxis) in Participants at Risk of Acquiring HIV (Human Immunodeficiency Virus)

Role: lead

NCT02938520Phase 3Active Not Recruiting

Study to Evaluate the Efficacy, Safety, and Tolerability of Long-acting Intramuscular Cabotegravir and Rilpivirine for Maintenance of Virologic Suppression Following Switch From an Integrase Inhibitor in HIV-1 Infected Therapy Naive Participants

Role: lead

NCT06694805Phase 3Active Not Recruiting

A Study to Evaluate the Effectiveness of Long-acting (LA) Cabotegravir (CAB) + Rilpivirine (RPV) LA When Given to Participants With Detectable HIV-1

Role: lead

NCT05996471Phase 2Active Not Recruiting

A Study to Investigate the Virologic Efficacy and Safety of VH3810109 + Cabotegravir Compared to Standard of Care (SOC) in Male and Female Adults Living With Human Immunodeficiency Virus (HIV)

Role: lead

NCT06451341Active Not Recruiting

IMplementation of CAB+RPV LA for People With HIV in Non-Metropolitan Areas

Role: collaborator

NCT07202546Phase 2Recruiting

A Phase 2b Study Evaluating Oral VH4524184 Regimens in Treatment Naïve Persons With HIV-1 (INNOVATE Study)

Role: lead

NCT05630872Phase 2Completed

Pharmacokinetics and Safety of Double-dose Dolutegravir When Used With Rifapentine for HIV-associated Tuberculosis

Role: collaborator

NCT02656511Phase 4Active Not Recruiting

Immediate Initiation of Antiretroviral Therapy During "Hyperacute" HIV Infection

Role: collaborator

NCT07525544Phase 1Recruiting

A Study to Investigate the Safety and PK of VH4770359 in Healthy Participants

Role: lead

NCT05911360Phase 3Completed

A Study to Evaluate Efficacy, Safety and Tolerability in Antiretroviral Therapy (ART)-Experienced Participants of at Least 50 Years of Age Living With Human Immunodeficiency Virus (HIV) With Virologic Suppression Who Switch to DTG/3TC FDC From BIC/FTC/TAF

Role: lead

NCT02951052Phase 3Active Not Recruiting

Study Evaluating the Efficacy, Safety, and Tolerability of Switching to Long-acting Cabotegravir Plus Long-acting Rilpivirine From Current Antiretroviral Regimen in Virologically Suppressed HIV-1-infected Adults

Role: lead

NCT07053384Phase 1Active Not Recruiting

A Study to Investigate the Use of VH3810109 With or Without Fostemsavir (FTR) to Reduce the Size and Activity of the Viral Reservoir in People Living With HIV

Role: lead

NCT07636928Phase 1Recruiting

Mass Balance and Absolute Oral Bioavailability of [14C]VH4524184

Role: lead

NCT05979311Phase 3Active Not Recruiting

A Study to Evaluate the Efficacy, Safety, and Tolerability of Using an Oral Once-daily 2 Drug Regimen Compared to an Oral Once-daily 3 Drug Regimen for the Treatment of Human Immunodeficiency Virus (HIV)-1 in Adults Who Have Not Previously Taken Antiretroviral Therapy

Role: lead

NCT06310551Phase 1Recruiting

First Time in Human Study of Long Acting VH4524184 Formulations

Role: lead

NCT06652958Phase 1Active Not Recruiting

A Study to Assess the Safety and Pharmacokinetics of a Human Monoclonal Antibody (VH4527079) in Healthy Adults and Persons With HIV

Role: lead

NCT03635788Phase 3Active Not Recruiting

The LATITUDE Study: Long-Acting Therapy to Improve Treatment SUccess in Daily LifE

Role: collaborator

NCT07650916Phase 3Not Yet Recruiting

A Study to Investigate Cabotegravir Ultra Long-Acting (CAB ULA) Plus Rilpivirine Ultra Long-Acting (RPV ULA) in Adults and Adolescents With HIV Who Are Virologically Suppressed

Role: lead

NCT07658976Phase 3Not Yet Recruiting

Duo: A Phase IIIb Individual-Level Randomized Controlled Trial of an Integrated Strategy

Role: collaborator