Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

Moderate Risk

Score: 45/100

Failure Rate

18.2%

4 terminated/withdrawn out of 22 trials

Success Rate

81.0%

-5.6% vs industry average

Late-Stage Pipeline

23%

5 trials in Phase 3/4

Results Transparency

82%

14 of 17 completed trials have results

Key Signals

14 with results

Enrollment Performance

Analytics

Phase 1
9(42.9%)
Phase 2
7(33.3%)
Phase 3
5(23.8%)
21Total
Phase 1(9)
Phase 2(7)
Phase 3(5)

Activity Timeline

Global Presence

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Clinical Trials (22)

Showing 20 of 22 trials
NCT02975934Phase 3Completed

A Study of Rucaparib Versus Physician's Choice of Therapy in Participants With Metastatic Castration-resistant Prostate Cancer and Homologous Recombination Gene Deficiency

Role: lead

NCT03522246Phase 3Active Not Recruiting

A Study in Ovarian Cancer Patients Evaluating Rucaparib and Nivolumab as Maintenance Treatment Following Response to Front-Line Platinum-Based Chemotherapy

Role: lead

NCT02654990Phase 2Completed

Panobinostat/Bortezomib/Dexamethasone in Relapsed or Relapsed-and-refractory Multiple Myeloma

Role: lead

NCT04676334Phase 3Completed

CATCH-R: A Rollover Study to Provide Continued Access to Rucaparib

Role: lead

NCT03992131Phase 1Terminated

A Study to Evaluate Rucaparib in Combination With Other Anticancer Agents in Participants With a Solid Tumor (SEASTAR)

Role: lead

NCT04171700Phase 2Terminated

A Study to Evaluate Rucaparib in Participants With Solid Tumors and With Deleterious Mutations in HRR Genes

Role: lead

NCT04179396Phase 1Completed

Study of Oral Rucaparib With Other Anticancer Agents in Metastatic Castration Resistant Prostate Cancer Patients (RAMP)

Role: lead

NCT04150289Completed

A Disease Registry Encompassing the Care Of Patients With Multiple Myeloma on Panobinostat

Role: lead

NCT02042378Phase 2Completed

A Study of Rucaparib in Patients With Pancreatic Cancer and a Known Deleterious BRCA Mutation

Role: lead

NCT01891344Phase 2Completed

A Study of Rucaparib in Patients With Platinum-Sensitive, Relapsed, High-Grade Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer (ARIEL2)

Role: lead

NCT03824704Phase 2Terminated

A Study to Evaluate Rucaparib in Combination With Nivolumab in Patients With Selected Solid Tumors (ARIES)

Role: lead

NCT02740712Phase 1Completed

Pharmacokinetic Drug-Drug Interaction Study of Rucaparib

Role: lead

NCT01968213Phase 3Completed

Phase 3 Study of Rucaparib as Switch Maintenance After Platinum in Relapsed High Grade Serous or Endometrioid Ovarian Cancer (ARIEL3)

Role: lead

NCT02986100Phase 1Completed

Absorption, Metabolism, and Excretion Following a Single Oral Dose of [14C]-Rucaparib

Role: lead

NCT02855944Phase 3Completed

ARIEL4: A Study of Rucaparib Versus Chemotherapy BRCA Mutant Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Patients

Role: lead

NCT03499444Phase 1Completed

A Study of Rucaparib in Japanese Patients With a Previously-treated Solid Tumor

Role: lead

NCT01482715Phase 1Completed

A Study of Oral Rucaparib in Patients With a Solid Tumor (Phase I) or With gBRCA Mutation Ovarian Cancer (Phase II)

Role: lead

NCT03521037Phase 1Completed

Rucaparib Hepatic Impairment Study in Patients With a Solid Tumor

Role: lead

NCT03397394Phase 2Terminated

Rucaparib in Patients With Locally Advanced or Metastatic Urothelial Carcinoma

Role: lead

NCT02952534Phase 2Completed

A Study of Rucaparib in Patients With Metastatic Castration-resistant Prostate Cancer and Homologous Recombination Gene Deficiency

Role: lead