Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

High Risk

Score: 70/100

Failure Rate

26.9%

7 terminated/withdrawn out of 26 trials

Success Rate

65.0%

-21.5% vs industry average

Late-Stage Pipeline

8%

2 trials in Phase 3/4

Results Transparency

131%

17 of 13 completed trials have results

Key Signals

1 recruiting17 with results

Enrollment Performance

Analytics

Phase 2
18(81.8%)
Phase 1
2(9.1%)
Phase 3
2(9.1%)
22Total
Phase 2(18)
Phase 1(2)
Phase 3(2)

Activity Timeline

Global Presence

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Clinical Trials (26)

Showing 20 of 26 trials
NCT07536815Unknown

An Open-Label, Multicenter, Non-Randomized Expanded Access Protocol (EAP) Designed to Provide Leronlimab to Patients With Locally Advanced or Metastatic Triple-Negative Breast Cancer (mTNBC)

Role: lead

NCT02859961Phase 2Completed

Study of PRO 140 SC as Single Agent Maintenance Therapy in Virally Suppressed Subjects With CCR5-tropic HIV-1 Infection

Role: lead

NCT04504942Phase 2Completed

Basket Study of Leronlimab (PRO 140) in Patients With CCR5+ Locally Advanced or Metastatic Solid Tumors

Role: lead

NCT02990858Phase 2Terminated

An Extension Protocol for Subjects Who Successfully Completed PRO140_CD02 or PRO140_CD02_Open Label Study

Role: lead

NCT05271370Phase 2Terminated

An Extension Protocol for Virologically Suppressed Subjects Who Successfully Completed PRO140_CD03 Study

Role: lead

NCT04347239Phase 2Completed

Evaluate the Efficacy & Safety of Leronlimab in Patients With Severe or Critical COVID-19

Role: lead

NCT02355184Phase 2Terminated

An Extension of Protocol PRO 140_CD01 Study

Role: lead

NCT06699836Phase 2Recruiting

A Phase 2 Study of Leronlimab in Combination With TAS-102 + Bevacizumab in Previously Treated Participants With mCRC

Role: lead

NCT03902522Phase 2Completed

PRO 140 in Treatment-Experienced HIV-1 Subjects

Role: lead

NCT03838367Phase 1Terminated

Leronlimab (PRO 140) Combined With Carboplatin in Patients With Cytokine Chemokine Receptor 5 Positive (CCR5+) mTNBC

Role: lead

NCT04313075Unknown

A Compassionate Use Study of Leronlimab in Breast Cancer

Role: lead

NCT04678830Phase 2Completed

Double Blind, Placebo Controlled Study of Safety and Efficacy of Leronlimab in Patients With "Long" COVID-19

Role: lead

NCT02737306Phase 2Terminated

A Study of Acute Graft-Versus-Host Disease (GVHD) in Patients Undergoing Allogeneic Stem-Cell Transplantation

Role: lead

NCT02175680Phase 2Completed

Treatment Substitution With PRO 140 Monotherapy in Adult Subjects With HIV-1 Infection

Role: lead

NCT00110591Phase 1Completed

Safety and Tolerability of PRO 140 in HIV Uninfected Male Volunteers

Role: lead

NCT04521114Phase 2Completed

Leronlimab (PRO 140) in Patients With Nonalcoholic Steatohepatitis

Role: lead

NCT05730673Phase 2Withdrawn

Leronlimab in Combination With Regorafenib in Patients With CCR5+, Metastatic Colorectal Cancer

Role: lead

NCT04343651Phase 2Completed

Study to Evaluate the Efficacy and Safety of Leronlimab for Mild to Moderate COVID-19

Role: lead

NCT02483078Phase 2Completed

Randomized, Double-Blind, Placebo-Controlled Trial, Followed by Single-Arm Treatment of PRO 140

Role: lead

NCT04901676Phase 3Suspended

Leronlimab in Moderately Ill Patients With COVID-19 Pneumonia

Role: collaborator