Success Metrics

Clinical Success Rate
88.2%

Based on 30 completed trials

Completion Rate
88%(30/34)
Active Trials
3(5%)
Results Posted
23%(7 trials)
Terminated
4(6%)

Phase Distribution

Ph phase_3
7
11%
Ph phase_4
18
27%
Ph not_applicable
22
33%
Ph phase_1
4
6%
Ph early_phase_1
1
2%
Ph phase_2
12
18%

Phase Distribution

5

Early Stage

12

Mid Stage

25

Late Stage

Phase Distribution64 total trials
Early Phase 1First-in-human
1(1.6%)
Phase 1Safety & dosage
4(6.3%)
Phase 2Efficacy & side effects
12(18.8%)
Phase 3Large-scale testing
7(10.9%)
Phase 4Post-market surveillance
18(28.1%)
N/ANon-phased studies
22(34.4%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

76.9%

30 of 39 finished

Non-Completion Rate

23.1%

9 ended early

Currently Active

3

trials recruiting

Total Trials

66

all time

Status Distribution
Active(10)
Completed(30)
Terminated(9)
Other(17)

Detailed Status

Completed30
unknown17
Not yet recruiting6
Withdrawn5
Terminated4
Recruiting3

Development Timeline

Analytics

Development Status

Total Trials
66
Active
3
Success Rate
88.2%
Most Advanced
Phase 4

Trials by Phase

Early Phase 11 (1.6%)
Phase 14 (6.3%)
Phase 212 (18.8%)
Phase 37 (10.9%)
Phase 418 (28.1%)
N/A22 (34.4%)

Trials by Status

terminated46%
withdrawn58%
unknown1726%
completed3045%
not_yet_recruiting69%
recruiting35%
enrolling_by_invitation12%

Recent Activity

Clinical Trials (66)

Showing 20 of 66 trialsScroll for more
NCT07534995Phase 3

A Prospective, Multicenter, Randomized, Parallel-controlled, Superiority Trial

Not Yet Recruiting
NCT07354100Phase 1

Lactulose to Improve Gut Health in Cancer Patients Receiving Immunotherapy

Not Yet Recruiting
NCT07273734Not Applicable

UDCA to Prevent Post-TIPS Hepatic Encephalopathy

Not Yet Recruiting
NCT05794555Phase 3

LiveSMART Trial to Prevent Falls in Patients With Cirrhosis

Completed
NCT05754996Phase 3

Efficacy and Safety of Nifuroxazide in the Treatment of Hepatic Encephalopathy in Egyptian Patients With Liver Cirrhosis

Completed
NCT06483737Not Applicable

Human Albumin Infusion in Liver Cirrhosis and Overt Hepatic Encephalopathy (HACHE)

Recruiting
NCT07084350Not Applicable

Combination of Lactulose and Polyethylene Glycol Electrolytes Powder (PEG-ELS) for Bowel Preparation in Type II Diabetes Mellitus Patients

Not Yet Recruiting
NCT07037394Phase 4

A Trial for Comparing Rifaximin, Probiotic and L-ornithine- L Aspartate With Lactulose in Overt Hepatic Encephalopathy.

Completed
NCT00001337Phase 2

Dose-Adjusted EPOCH Chemotherapy and Rituximab (CD20+) in Previously Untreated Aggressive Non-Hodgkin's Lymphoma

Completed
NCT06538077Phase 4

BCAA vs. Rifaximin in Patients With Cirrhosis for Secondary Prophylaxis of HE

Recruiting
NCT05700695Phase 1

Intravenous BCAA for HE in ACLF (BCAA-HE-ACLF)

Completed
NCT07002827Not Applicable

Effect of Single vs Repeated Cycles of a Combination of Granulocyte Colony Stimulating Factor and Darbepoetin vs Standard Medical Treatment on Immunometabolic Profile in Patient With Early Decompensated Cirrhosis.

Not Yet Recruiting
NCT06835361Phase 2

Efficacy and Safety of Clotrimazole+Lactulose Vaginal Suppositories Vs. Clotrimazole Monotherapy in Adult Women with Candidal Vaginitis/Vulvovaginitis

Recruiting
NCT06808009Not Applicable

Goal Directed Ammonia Lowering Therapy in Hyperammonemic ACLF Patients With no Overt HE to Reduce Major Adverse Liver Related Outcomes (GOAL Trial)

Not Yet Recruiting
NCT06748638Phase 4

Clinical Study on the Application of Lactulose Combined with Linaclotide in Bowel Preparation for Colonoscopy

Enrolling By Invitation
NCT05726344Not Applicable

Lactulose vs. Polyethylene Glycol as Bowel Preparation for Colonoscopy in Adults

Completed
NCT05061992Phase 2

A Trial to Improve Quality of Life in People With Cirrhosis

Completed
NCT05934552

Assesment of Lactulose vs Lactobacillus Acidophilus Effect in CKD Patients

Unknown
NCT04436601Phase 4

Polyethylene Glycol Versus Lactulose on Hepatic Encephalopathy in Patients With Cirrhosis;(PEGHE Trial)

Unknown
NCT05788627Phase 4

Effectiveness of Oral Lactulose Versus Lactulose Enema in Hepatic Encephalopathy

Unknown

Drug Details

Intervention Type
DRUG
Total Trials
66