Success Metrics

Clinical Success Rate
56.3%

Based on 18 completed trials

Completion Rate
56%(18/32)
Active Trials
8(17%)
Results Posted
89%(16 trials)
Terminated
14(30%)

Phase Distribution

Ph phase_2
24
52%
Ph phase_3
1
2%
Ph phase_1
20
43%

Phase Distribution

20

Early Stage

24

Mid Stage

1

Late Stage

Phase Distribution45 total trials
Phase 1Safety & dosage
20(44.4%)
Phase 2Efficacy & side effects
24(53.3%)
Phase 3Large-scale testing
1(2.2%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

50.0%

18 of 36 finished

Non-Completion Rate

50.0%

18 ended early

Currently Active

8

trials recruiting

Total Trials

46

all time

Status Distribution
Active(8)
Completed(18)
Terminated(18)
Other(2)

Detailed Status

Completed18
Terminated14
Active, not recruiting5
Withdrawn4
Recruiting3
unknown2

Development Timeline

Analytics

Development Status

Total Trials
46
Active
8
Success Rate
56.3%
Most Advanced
Phase 3

Trials by Phase

Phase 120 (44.4%)
Phase 224 (53.3%)
Phase 31 (2.2%)

Trials by Status

active_not_recruiting511%
completed1839%
recruiting37%
terminated1430%
unknown24%
withdrawn49%

Recent Activity

Clinical Trials (46)

Showing 20 of 46 trialsScroll for more
NCT04358185Phase 1

Itacitinib in Advanced Hepatocellular Carcinoma

Completed
NCT05660421Phase 2

Itacitinib for the Treatment Steroid Refractory Immune Related Adverse Events Arising From Immune Checkpoint Inhibitors

Withdrawn
NCT02257619Phase 2

Study of Itacitinib in Combination With Docetaxel in Subjects With Non-Small Cell Lung Cancer

Terminated
NCT04061421Phase 1

Active Myeloid Target Compound Combinations in MDS/MPN Overlap Syndromes Overlap Syndromes (ABNL-MARRO)

Recruiting
NCT04859946Phase 2

Itacitinib for the Prevention of Graft Versus Host Disease

Active Not Recruiting
NCT05757219Phase 2

Itacitinib Pre-modulation in DLBCL Receiving CAR T Cell Therapy

Recruiting
NCT02917993Phase 1

An Open-Label Phase 1/2 Study of Itacitinib in Combination With Osimertinib in Subjects With Non-Small Cell Lung Cancer

Completed
NCT05063110Phase 2

Treatment of Non Severe Hemophagocytosis Lymphohistiocytosis With ITACITINIB

Completed
NCT04640025Phase 2

A Rollover Study to Provide Continued Treatment for Participants Previously Enrolled in Studies of Itacitinib

Active Not Recruiting
NCT04789850Phase 2

Safety and Efficacy of Itacitinib in Adults With Systemic Sclerosis

Recruiting
NCT04239989Phase 1

Itacitinib for the Treatment of Bronchiolitis Obliterans Syndrome After Donor Hematopoietic Cell Transplant

Terminated
NCT03721965Phase 1

Safety and Efficacy of Itacitinib in Combination With Corticosteroids for Treatment of Graft-Versus-Host Disease in Pediatric Subjects

Terminated
NCT03320642Phase 1

GRAVITAS-119: Itacitinib in Combination With Calcineurin Inhibitor-Based Interventions for the Prophylaxis of Graft-Versus Host Disease

Terminated
NCT03978637Phase 1

Safety and Efficacy of Itacitinib in Participants With Bronchiolitis Obliterans Syndrome Following Lung Transplantation

Terminated
NCT03584516Phase 2

GRAVITAS-309: Itacitinib and Corticosteroids as Initial Treatment for Chronic Graft-Versus-Host Disease

Terminated
NCT05823571Phase 1

Itacitinib With High-dose Posttransplantation Cyclophosphamide in Older Patients

Active Not Recruiting
NCT03139604Phase 3

GRAVITAS-301: A Study of Itacitinib or Placebo in Combination With Corticosteroids for Treatment of Acute Graft-Versus-Host Disease

Completed
NCT04629508Phase 2

To Assess the Safety, Tolerability and Efficacy of Itacitinib Immediate Release Tablets in Participants With Primary or Secondary Myelofibrosis Who Have Received Prior Ruxolitinib and/or Fedratinib Monotherapy (LIMBER-213)

Completed
NCT05561985

Expanded Access Use of Itacitinib to Treat a Single Patient With STAT1 Gain of Function (GOF) Disease

Unknown
NCT03697408Phase 1

Itacitinib + Everolimus in Hodgkin Lymphoma

Active Not Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
46