Success Metrics

Clinical Success Rate
79.4%

Based on 50 completed trials

Completion Rate
79%(50/63)
Active Trials
3(4%)
Results Posted
42%(21 trials)
Terminated
13(16%)

Phase Distribution

Ph phase_4
14
18%
Ph early_phase_1
1
1%
Ph not_applicable
6
8%
Ph phase_2
22
28%
Ph phase_3
21
27%
Ph phase_1
13
16%

Phase Distribution

14

Early Stage

22

Mid Stage

35

Late Stage

Phase Distribution77 total trials
Early Phase 1First-in-human
1(1.3%)
Phase 1Safety & dosage
13(16.9%)
Phase 2Efficacy & side effects
22(28.6%)
Phase 3Large-scale testing
21(27.3%)
Phase 4Post-market surveillance
14(18.2%)
N/ANon-phased studies
6(7.8%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

78.1%

50 of 64 finished

Non-Completion Rate

21.9%

14 ended early

Currently Active

3

trials recruiting

Total Trials

79

all time

Status Distribution
Active(4)
Completed(50)
Terminated(14)
Other(11)

Detailed Status

Completed50
Terminated13
unknown11
Recruiting2
Withdrawn1
Active, not recruiting1

Development Timeline

Analytics

Development Status

Total Trials
79
Active
3
Success Rate
79.4%
Most Advanced
Phase 4

Trials by Phase

Early Phase 11 (1.3%)
Phase 113 (16.9%)
Phase 222 (28.6%)
Phase 321 (27.3%)
Phase 414 (18.2%)
N/A6 (7.8%)

Trials by Status

withdrawn11%
unknown1114%
active_not_recruiting11%
completed5063%
not_yet_recruiting11%
recruiting23%
terminated1316%

Recent Activity

Clinical Trials (79)

Showing 20 of 79 trialsScroll for more
NCT06957002Phase 2

Bosentan in the Treatment of Giant Cell Arteritis

Not Yet Recruiting
NCT01241383Phase 2

Effect of Bosentan in Scleroderma Renal Crisis

Completed
NCT04158635Phase 1

Gemcitabine, Nab-Paclitaxel, and Bosentan for the Treatment of Unresectable Pancreatic Cancer

Recruiting
NCT05723874Phase 1

A Study in Healthy Men to Test Whether Bosentan Influences the Amount of BI 425809 in the Blood

Completed
NCT04388124Phase 2

Endothelin-1 Receptor Blockade in Resistant Hypertension

Recruiting
NCT00777985Phase 2

Preventive Effects of Bosentan on the Systemic Cardiovascular Consequence of Sleep Apnea

Completed
NCT07081932Phase 1

A Study in Healthy Men to Test How Bosentan Influences the Amount of Nerandomilast in the Blood

Completed
NCT05072106Phase 1

Study to Evaluate the Effect of Bosentan on the Pharmacokinetics of Lurbinectedin in Patients With Advanced Solid Tumors

Completed
NCT01338415Phase 3

FUTURE 3 Study Extension

Completed
NCT00433329Phase 4

Combination Therapy in Pulmonary Arterial Hypertension

Completed
NCT00302211Phase 3

The "VISION" Trial: Ventavis Inhalation With Sildenafil to Improve and Optimize Pulmonary Arterial Hypertension

Terminated
NCT01223352Phase 3

Effects of Two Dosing Regimens of Bosentan in Children With Pulmonary Arterial Hypertension

Completed
NCT00303459Phase 4

Effects of the Combination of Bosentan and Sildenafil Versus Sildenafil Monotherapy on Pulmonary Arterial Hypertension (PAH)

Completed
NCT00631475Phase 3

Open Label Extension Study in Patients With Idiopathic Pulmonary Fibrosis Who Completed Protocol AC-052-321/ BUILD 3 / NCT00391443

Completed
NCT01389856Phase 3

Persistent Pulmonary Hypertension of the Newborn

Terminated
NCT00313196Phase 3

Efficacy and Safety of Bosentan in Sickle Cell Disease (SCD) Patients Diagnosed With Pulmonary Hypertension (PH)

Terminated
NCT00319111Phase 3

Bosentan in Patients With Inoperable Chronic Thromboembolic Pulmonary Hypertension (CTEPH)

Completed
NCT00319020Phase 3

Bosentan in Children With Pulmonary Arterial Hypertension Extension Study

Completed
NCT00310830Phase 3

Efficacy and Safety of Bosentan in Sickle Cell Disease (SCD) Patients With Pulmonary Arterial Hypertension (PAH)

Terminated
NCT00317486Phase 4

Effects of Tracleer (Bosentan) on Pulmonary Arterial Hypertension Related to Eisenmenger Physiology

Completed

Drug Details

Intervention Type
DRUG
Total Trials
79