Success Metrics

Clinical Success Rate
81.0%

Based on 51 completed trials

Completion Rate
81%(51/63)
Active Trials
20(18%)
Results Posted
76%(39 trials)
Terminated
12(11%)

Phase Distribution

Ph early_phase_1
1
1%
Ph phase_1
27
24%
Ph phase_3
11
10%
Ph phase_2
54
48%
Ph phase_4
5
4%

Phase Distribution

28

Early Stage

54

Mid Stage

16

Late Stage

Phase Distribution98 total trials
Early Phase 1First-in-human
1(1.0%)
Phase 1Safety & dosage
27(27.6%)
Phase 2Efficacy & side effects
54(55.1%)
Phase 3Large-scale testing
11(11.2%)
Phase 4Post-market surveillance
5(5.1%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

75.0%

51 of 68 finished

Non-Completion Rate

25.0%

17 ended early

Currently Active

20

trials recruiting

Total Trials

112

all time

Status Distribution
Active(21)
Completed(51)
Terminated(17)
Other(23)

Detailed Status

Completed51
unknown22
Recruiting13
Terminated12
Active, not recruiting7
Withdrawn5

Development Timeline

Analytics

Development Status

Total Trials
112
Active
20
Success Rate
81.0%
Most Advanced
Phase 4

Trials by Phase

Early Phase 11 (1.0%)
Phase 127 (27.6%)
Phase 254 (55.1%)
Phase 311 (11.2%)
Phase 45 (5.1%)

Trials by Status

recruiting1312%
unknown2220%
suspended11%
active_not_recruiting76%
terminated1211%
withdrawn54%
enrolling_by_invitation11%
completed5146%

Recent Activity

Clinical Trials (112)

Showing 20 of 112 trialsScroll for more
NCT02465060Phase 2

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

Active Not Recruiting
NCT06385483Phase 2

Testing Afatinib as Potentially Targeted Treatment in Cancers With EGFR Genetic Changes (MATCH - Subprotocol A)

Active Not Recruiting
NCT06648096Phase 1

Afatinib in Patients With Fanconi Anemia (FA) and Advanced Head and Neck Squamous Cell Carcinoma (HNSCC)

Recruiting
NCT06302621Phase 1

Pemigatinib + Afatinib in Advanced Refractory Solid Tumors

Recruiting
NCT07040956Phase 2

A Clinical Trial Comparing Low-Dose RT + Targeted Therapy+ Immunotherapy vs Targeted Therapy+ Immunotherapy Alone as Neoadjuvant Therapy in Operable HNSCC Patients.

Recruiting
NCT01783587Phase 1

Safety Study of Afatinib and Postoperative Radiation Therapy to Treat Head and Neck Cancer

Completed
NCT02979977Phase 2

Dual Inhibition of EGFR With Afatinib and Cetuximab in the Treatment of Advanced Squamous Cell Cancers of the Head and Neck

Completed
NCT01856478Phase 3

LUX-Head&Neck 3: Afatinib (BIBW2992) Versus Methotrexate for the Treatment of Recurrent and/or Metastatic Head and Neck Squamous Cell Cancer After Platinum Based Chemotherapy

Completed
NCT06494189Phase 1

Low-dose Radiotherapy Plus Tislelizumab in Combination With Afatinib for Neoadjuvant Treatment of Surgically Resectable Head and Neck Squamous Carcinoma

Completed
NCT06085755Phase 1

Trastuzumab Deruxtecan(T-DXd) and Afatinib Combination in HER2-low Advanced Gastric Cancer

Recruiting
NCT06804850Phase 2

Neoadjuvant Radiotherapy Plus Targeted Therapy and Immunotherapy vs. Targeted Therapy Plus Immunotherapy in Resectable HNSCC

Withdrawn
NCT04185883Phase 1

Sotorasib Activity in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation (CodeBreak 101)

Active Not Recruiting
NCT02491099Phase 2

A Phase II Evaluation of Afatinib in Patients With Persistent or Recurrent HER2-positive Uterine Serous Carcinoma

Recruiting
NCT03785249Phase 1

Phase 1/2 Study of MRTX849 in Patients With Cancer Having a KRAS G12C Mutation KRYSTAL-1

Active Not Recruiting
NCT05517330Phase 2

Neoadjuvant Tislelizumab With Afatinib for Resectable Head and Neck Squamous Cell Carcinoma

Completed
NCT02191891Phase 1

Xentuzumab (BI 836845) Plus Afatinib in Patients With Epidermal Growth Factor Receptor (EGFR) Mutant Non-small Cell Lung Cancer (NSCLC)

Completed
NCT07010120Phase 1

A Clinical Trial of Neoadjuvant Targeted Therapy, Immunotherapy, and Lysogenic HSV-Based Virotherapy in Resectable Head and Neck Squamous Cell Carcinoma

Recruiting
NCT05516589Phase 2

Neoadjuvant Chemotherapy, Tislelizumab With Afatinib for HNSCC

Completed
NCT05432518Early Phase 1

Pilot Trial for Treatment of Recurrent Glioblastoma

Recruiting
NCT01853826Phase 3

An Open Label Trial of Afatinib (Giotrif) in Treatment-naive (1st Line) or Chemotherapy Pre-treated Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC) Harboring EGFR Mutation(s)

Completed

Drug Details

Intervention Type
DRUG
Total Trials
112