Key Insights

Highlights

Success Rate

64% trial completion

Published Results

109 trials with published results (30%)

Research Maturity

143 completed trials (40% of total)

Clinical Risk Assessment

Based on trial outcomes

High Risk

Score: 62/100

Termination Rate

22.1%

79 terminated out of 358 trials

Success Rate

64.4%

-22.1% vs benchmark

Late-Stage Pipeline

5%

18 trials in Phase 3/4

Results Transparency

76%

109 of 143 completed with results

Key Signals

109 with results64% success79 terminated

Data Visualizations

Phase Distribution

325Total
Not Applicable (25)
Early P 1 (5)
P 1 (156)
P 2 (121)
P 3 (10)
P 4 (8)

Trial Status

Completed143
Terminated79
Recruiting44
Active Not Recruiting40
Unknown24
Withdrawn24

Trial Success Rate

64.4%

Benchmark: 86.5%

Based on 143 completed trials

Clinical Trials (358)

Showing 20 of 20 trials
NCT05136196Phase 2Recruiting

BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

NCT03122522Phase 2Active Not RecruitingPrimary

A Study to Evaluate Adaptive Dosing of Ipilimumab and Nivolumab Combination Immunotherapy

NCT03025256Phase 1Recruiting

Intravenous and Intrathecal Nivolumab in Treating Patients With Leptomeningeal Disease

NCT07281924Phase 1RecruitingPrimary

Hepzato Kit and Opdualag for Metastatic Melanoma and Liver Metastasis

NCT07405086Phase 4Recruiting

Morning Versus Afternoon Administration of Immunotherapy for the Treatment of Advanced or Metastatic Solid Tumors, The Knight SHIFT Study

NCT06500455Phase 3Recruiting

Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain

NCT07564570Not ApplicableRecruitingPrimary

Physical Activity Directly Before Immunotherapy (Nivolumab and Ipilimumab) in Melanoma

NCT06060613Phase 1Recruiting

Safety and Efficacy of OBX-115 in Advanced Solid Tumors

NCT05896839Phase 1Recruiting

Immunotherapy in Combination With Prednisone and Sirolimus for Kidney Transplant Recipients With Unresectable or Metastatic Skin Cancer

NCT03816332Phase 1Active Not Recruiting

Tacrolimus, Nivolumab, and Ipilimumab in Treating Kidney Transplant Recipients With Selected Unresectable or Metastatic Cancers

NCT02581930Phase 2Active Not RecruitingPrimary

Ibrutinib in Treating Patients With Refractory Metastatic Cutaneous Melanoma

NCT06151847Phase 2Completed

Lifileucel With Reduced Dose Fludarabine/Cyclophosphamide Lymphodepletion and Interleukin-2 for the Treatment of Patients With Unresectable or Metastatic Melanoma

NCT01134614Phase 2Active Not Recruiting

Ipilimumab With or Without Sargramostim in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed by Surgery

NCT05764395Phase 2Active Not Recruiting

Rigosertib Plus Pembrolizumab in Treating Patients With Unresectable/Metastatic Melanoma Refractory to PD-1 Inhibitors

NCT01416831Phase 2Active Not RecruitingPrimary

Comparison of High-dose IL-2 and High-dose IL-2 With Radiation Therapy in Patients With Metastatic Melanoma.

NCT05341349Phase 1Terminated

Stereotactic Radiosurgery and Immune Checkpoint Inhibitors With NovoTTF-200M for the Treatment of Melanoma Brain Metastases

NCT01590069Phase 1Active Not Recruiting

Aerosolized Aldesleukin in Treating Patients With Lung Metastases

NCT07504796Phase 4RecruitingPrimary

ctDNA-guided Addition of Ipilimumab to Patients Receiving Nivolumab and Relatlimab

NCT03149029Phase 2Active Not RecruitingPrimary

Abbreviated MAPK Targeted Therapy Plus Pembrolizumab in Melanoma

NCT05398640Unknown

Expanded Access Program of AMTAGVI That is Out of Specification for Commercial Release

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Research Network

Activity Timeline