Key Insights

Highlights

Success Rate

100% trial completion (above average)

Clinical Risk Assessment

Based on trial outcomes

Moderate Risk

Score: 40/100

Termination Rate

0.0%

0 terminated out of 15 trials

Success Rate

100.0%

+13.5% vs benchmark

Late-Stage Pipeline

13%

2 trials in Phase 3/4

Results Transparency

13%

1 of 8 completed with results

Key Signals

1 with results100% success

Data Visualizations

Phase Distribution

9Total
Not Applicable (2)
P 1 (3)
P 2 (2)
P 3 (2)

Trial Status

Completed8
Active Not Recruiting3
Enrolling By Invitation2
Unknown1
Recruiting1

Trial Success Rate

100.0%

Benchmark: 86.5%

Based on 8 completed trials

Clinical Trials (15)

Showing 15 of 15 trials
NCT05051657Not ApplicableCompleted

Evaluation of the Express Plus Range

NCT06495567Not ApplicableActive Not RecruitingPrimary

Proof of Concept Creatine Supplementation for Homocystinuria Study

NCT05687474Completed

Baby Detect : Genomic Newborn Screening

NCT06431893Phase 3Enrolling By InvitationPrimary

A Phase 3 Long-term Extension Study to Assess the Long-term Safety and Efficacy of Pegtibatinase Treatment in Participants ≥5 to ≤65 Years of Age With Classical Homocystinuria (HCU) (ENSEMBLE)

NCT06556615RecruitingPrimary

Health Related Quality of Life (HrQoL) in Classical Homocystinuria (CBS Deficiency)

NCT06247085Phase 3Active Not RecruitingPrimary

A Study to Investigate Efficacy and Safety of Pegtibatinase Compared With Placebo in Participants ≥12 to ≤65 Years of Age With Classical Homocystinuria (HCU) Due to Cystathionine Beta Synthase Deficiency Receiving Standard of Care Treatment

NCT03655223Enrolling By Invitation

Early Check: Expanded Screening in Newborns

NCT03406611Phase 1Active Not RecruitingPrimary

Pegtibatinase As an Enzyme Therapy for Patients with Homocystinuria Caused by Cystathionine Beta-Synthase Deficiency (COMPOSE)

NCT05910151Unknown

Selective Screening of Children for Hereditary Metabolic Diseases by Tandem Mass Spectrometry in Kazakhstan

NCT05462132Phase 1CompletedPrimary

Safety, Tolerability and Pharmacodynamics of SYNB1353 in Healthy Adult Volunteers

NCT02404337Phase 2CompletedPrimary

Betaine METABOLISM OF PATIENTS With Homocystinuria

NCT04021732CompletedPrimary

Effects of Exercise on Metabolic Parameters in Classical Homocystinuria

NCT01192828Phase 1CompletedPrimary

Oxidative Stress Markers In Inherited Homocystinuria And The Impact Of Taurine

NCT00483314Phase 2CompletedPrimary

Homocystinuria: Treatment With N-Acetylcysteine

NCT00004356CompletedPrimary

Study of Homocysteine Metabolism in Homocystinuria

Showing all 15 trials

Research Network

Activity Timeline