Local tenecteplase applicatiOn subsequent to endovasCular recanalization in Anterior circuLation stroke - the LOCAL trial
interventional
N/A
1 country
15
To investigate whether supplementary intra-arterial administration of thrombolysis (Tenecteplase) after successful endovascular recanalization of anterior circulation ischemic stroke results in improved clinical outcome evaluated based on the proportion of patients with an excellent clinical outcome of mRS 0 – 1 after 90 days +/- 15 days
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
Not reported
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
August 20, 2025
Actual (reported)To investigate whether supplementary intra-arterial administration of thrombolysis (Tenecteplase) after successful endovascular recanalization of anterior circulation ischemic stroke results in improved clinical outcome evaluated based on the proportion of patients with an excellent clinical outcome of mRS 0 – 1 after 90 days +/- 15 days
These entries preserve how the registry describes the intervention. Their treatment roles are shown separately from molecular identities.
Formulated product
Metalyse 5 000 units (25 mg) powder for solution for injection
The registry describes a specific formulation. Its exact chemical ingredients and approval status require separate evidence.
SOLUTION FOR INJECTION
View registry recordThe registry names these ingredients. The formulation’s exact chemical form has not been confirmed.
Metalyse 5 000 units (25 mg) powder for solution for injection
Named ingredient: Tenecteplase
View registry recordRegistry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Universitaetsklinikum Aachen AöR
Aachen, 52074, Germany
Universitaetsklinikum Bonn AöR
Bonn, 53127, Germany
Johannes Wesling Klinikum Minden
Minden, 32429, Germany
Prof. Dr. med. Markus Möhlenbruch
First Submitted
August 20, 2025
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Source: European Medicines Agency (EMA), Clinical Trials Information System (CTIS). Original record and public documents are available on CTIS.
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Source retrieved:
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Universitaetsklinikum Heidelberg AöR
Heidelberg, 69120, Germany
Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz KöR
Mainz, 55131, Germany
DIAKO Krankenhaus gGmbH
Flensburg, 24939, Germany
Alfried Krupp Zentrum fuer Medizin und Rehabilitation gGmbH
Essen, 45131, Germany
Universitaetsklinikum Wuerzburg AöR
Wuerzburg, 97080, Germany
Klinikum Dortmund gGmbH
Dortmund, 44137, Germany
RKH Klinken Ludwigsburg-Bietigheim gGmbH
Ludwigsburg, 71640, Germany
Universitaetsklinikum Augsburg
Augsburg, 86156, Germany
Klinikum Nuernberg
Nuremberg, 90471, Germany
HELIOS Klinikum Erfurt GmbH
Erfurt, 99089, Germany
Medical Center - University Of Freiburg
Freiburg Im Breisgau, 79106, Germany
Evangelisches Klinikum Bethel gGmbH
Bielefeld, 33617, Germany