NCT07902323|Not Yet Recruiting
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Sponsor study identifier
interventional
80
0 countries
N/A
Study Start
December 1, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Primary Completion
December 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
December 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
This study will assess the effectiveness of erythritol and xylitol in suppressing biofilm activity, using both within-subject and between-group comparisons.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
October 21, 2026
Actual (reported)October 28, 2026
Actual (reported)December 1, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
December 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
December 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Biofilm Metabolic Activity Assessment with Xylitol
Plaque from the lingual surfaces of the lower anterior teeth is swabbed and read immediately with the CariScreen ATP meter (relative light units, 0-9,999; higher = more bacterial metabolic activity). Change = 1 week post-baseline minus baseline, reported within each arm.
Change in biofilm activity between Visit 1 (baseline) and Visit 2 (1 week post-baseline)
Biofilm Metabolic Activity Assessment with Erythritol
Plaque from the lingual surfaces of the lower anterior teeth is swabbed and read immediately with the CariScreen ATP meter (relative light units, 0-9,999; higher = more bacterial metabolic activity). Change = 1 week post-baseline minus baseline, reported within each arm.
Change in biofilm activity between Visit 1 (baseline) and Visit 2 (1 week post-baseline)
Change in ATP reading by baseline caries risk category
Change in biofilm activity between Visit 1 (baseline) and Visit 2 (1 week post-baseline) by risk category (low, moderate, high)
Two Epic Xylitol mints (about 0.25 g xylitol each) dissolved in the mouth twice daily for one week, about 1 g xylitol per day.
One DC24 Daily Care erythritol mint (about 0.5 g erythritol) dissolved in the mouth twice daily for one week, about 1 g erythritol per day.
Participants will consume two Epic Xylitol mints (\~0.25 g xylitol each) twice daily for one week
Participants will consume one DC24 erythritol mint (\~0.5 g erythritol) twice daily for one week
Burt BA. The use of sorbitol- and xylitol-sweetened chewing gum in caries control. J Am Dent Assoc. 2006 Feb;137(2):190-6. doi: 10.14219/jada.archive.2006.0144.
Soderling E, Pienihakkinen K. Effects of xylitol and erythritol consumption on mutans streptococci and the oral microbiota: a systematic review. Acta Odontol Scand. 2020 Nov;78(8):599-608. doi: 10.1080/00016357.2020.1788721. Epub 2020 Jul 7.
So Ran Kwon, DDS, MS, PhD
Loma Linda University
First Submitted
October 21, 2026
First Posted
October 28, 2026
Study Start
December 1, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Disclosing Agents as Photosensitizers in aPDT for Biofilm Control in Children
Contact the study team to confirm eligibility.
Salli KM, Gursoy UK, Soderling EM, Ouwehand AC. Effects of Xylitol and Sucrose Mint Products on Streptococcus mutans Colonization in a Dental Simulator Model. Curr Microbiol. 2017 Oct;74(10):1153-1159. doi: 10.1007/s00284-017-1299-6. Epub 2017 Jul 17.
Rechmann P, Chaffee BW, Rechmann BMT, Featherstone JDB. Efficacy of an adenosine triphosphate meter for evaluating caries risk in clinical dental practice. J Am Dent Assoc. 2019 Oct;150(10):873-882. doi: 10.1016/j.adaj.2019.05.025. Epub 2019 Aug 28.
Martins ML, Monteiro ASN, Vieira TI, Guimaraes MBCT, de Abreu LCL, Cabral LM, Cavalcanti YW, Maia LC, Fonseca-Goncalves A. Effect of xylitol tablets with and without red propolis on salivary parameters, dental biofilm and sensory acceptability of adolescents: a randomized crossover clinical trial. Biofouling. 2020 Nov;36(10):1182-1195. doi: 10.1080/08927014.2020.1858063. Epub 2020 Dec 17.
Primary Completion
December 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
December 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
October 28, 2026
Record last verified: 2026-10
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