NCT07901426|Active Not Recruiting
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Sponsor study identifier
interventional
40
1 country
1
Study Start
June 1, 2026
Actual (reported)Primary Completion
December 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
January 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
The study aims to evaluate the efficacy of two formulations on human scalp skin against established standard treatment of 5% minoxidil and base formula (placebo). A total of 40 healthy adults, aged 18 to 60 with alopecia, baldness, or self-identified with symptoms of hair thinning will be recruited and randomly assigned into four groups (n=10 for each group) receiving different formulations. Participants will use the product twice daily (once in the morning and once in the evening) for 84 days, and their scalp conditions will be assessed through skin texture tests at multiple time points. Key parameters such as sebum content, overall hair loss, hair density, scalp condition, and hair length will be measured at an interval of two weeks for a total of seven times, including baseline measurements.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
January 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
June 1, 2026
Actual (reported)October 21, 2026
Actual (reported)October 28, 2026
Actual (reported)December 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
January 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Sebum Content
Assess oil levels on the scalp at standardized scalp sites (left, right, and vertex). Measured with C+K Multi Probe Adaptor MPA580 system using the Sebumeter® SM815 probe based on the grease spot photometry method with the sebum measurement cassette tape.
Assessment conducted every 14 days from Day 0 to Day 84 (including Day 0 as baseline)
Hair length
Hair length (in cm): Measured manually with ruler at standardized scalp sites (left, right, and vertex).
Assessment conducted every 14 days from Day 0 to Day 84 (including Day 0 as baseline)
Hair density
Hair density (number of hairs/cm-square): Assessed with the ScalpX Intelligent Scalp Diagnostic System with digital microscopy at standardized scalp sites (left, right, and vertex).
Base formula consisting of active ingredients 0.1% caffeine and panthenol (vitamin B5).
Base formula plus Centella asiatica extracellular vesicles, insulin growth factor-1 (IGF-1) and fibroblast growth factor-7 (FGF-7)
Base formula consisting of 0.1% caffeine and panthenol. Apply 1mL evenly to the scalp twice daily, once in the morning and once in the evening (after hair wash) for 84 consecutive days.
Base formula plus Centella asiatica extracellular vesicles, insulin growth factor-1 (IGF-1) and fibroblast growth factor-7 (FGF-7). Apply 1mL evenly to the scalp twice daily, once in the morning and once in the evening (after hair wash) for 84 consecutive days.
Hungkuang University
Taichung, 433304, Taiwan
Chang TM, Wu CC, Huang HC, Lu JY, Chuang CH, Kao PL, Tang WH, Hsieh WJ, Liu LT, Qiu WY, Percec I. Centella asiatica L. Urb. Extracellular Vesicle and Growth Factor Essence for Hair and Scalp Health: A 56-Day Exploratory Randomized Trial. Cosmetics. 2025 Nov 10;12(6):253.
40 participants (actual enrollment reported by the registry).
First Submitted
October 21, 2026
First Posted
October 28, 2026
Study Start
June 1, 2026
Actual (reported)A Clinical Trial to Examine the Efficacy of a Supplement to Support Healthy Hair and Skin
Assessment conducted every 14 days from Day 0 to Day 84 (including Day 0 as baseline)
Hair thickness
Hair thickness (in micrometers): Assessed with the ScalpX Intelligent Scalp Diagnostic System with digital microscopy at standardized scalp sites (left, right, and vertex).
Assessment conducted every 14 days from Day 0 to Day 84 (including Day 0 as baseline)
Hair loss
Assessed by the standardized hair combing test by counting the number of hairs shed after the participants' hair was combed over a clean surface for 60 strokes.
Assessment conducted every 14 days from Day 0 to Day 84 (including Day 0)
Base formula plus Centella asiatica and ginger (Zingiber officinale) extracellular vesicles, insulin growth factor-1 (IGF-1) and fibroblast growth factor-7 (FGF-7)
Commercial topical 5% minoxidil
Base formula plus Centella asiatica extracellular vesicles, insulin growth factor-1 (IGF-1) and fibroblast growth factor-7 (FGF-7). Apply 1mL evenly to the scalp twice daily, once in the morning and once in the evening (after hair wash) for 84 consecutive days.
Commercial 5% topical minoxidil solution. Apply 1mL evenly to the scalp twice daily, once in the morning and once in the evening (after hair wash) for 84 consecutive days.
Contact the study team to confirm eligibility.
Primary Completion
December 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
January 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
October 28, 2026
Record last verified: 2026-10
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