A Study to Evaluate the Effects of a Beef Liver Supplement on Energy, Mood, and Mental Clarity

NCT07892911 | Active Not Recruiting

• 2 other identifiers: #20806legacy-_20806
• Study Type: interventional
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

This is a randomized, triple-blind, placebo-controlled clinical trial evaluating the effects of the Ancestral Supplements Grass Fed Beef Liver oral supplement on energy, mood, and mental clarity over 12 weeks. One hundred male and female participants aged 18-50 who report concerns regarding energy levels, mood, and mental clarity will be enrolled and randomized equally into an intervention arm (beef liver supplement) or a placebo arm. Participants will take their assigned product once daily and complete self-reported questionnaires at Baseline, Week 4, Week 8, and Week 12. Blood testing (iron panel) will be conducted at Baseline and Week 12 at a local Quest Diagnostics Clinic. The primary objective is to evaluate the product's effects on energy and mood; the secondary objective is to assess participants' perceptions of the product's effects on energy, mood, and mental clarity, including happiness, anxiety, well-being, brain fog, and concentration.

Conditions

Fatigue; Low Mood; Mental Clarity; Iron Deficiency; Brain Fog

Outcome Measures

Primary Outcomes (3)

• Change in Iron Status

  Change in blood iron levels assessed via iron panel blood test (Quest Diagnostics, iron test code 001339)

  Baseline and Week 12

• Change in Energy Levels

  Change in self-reported energy levels assessed via self-reported questionnaire

  Baseline, Week 4, Week 8, and Week 12

• Change in Mood

  Change in self-reported mood assessed via self-reported questionnaire

  Baseline, Week 4, Week 8, and Week 12

Secondary Outcomes (6)

• Change in Self-Reported Vitality

  Baseline, Week 4, Week 8, and Week 12

• Change in Self-Reported Happiness

  Baseline, Week 4, Week 8, and Week 12

• Change in Self-Reported Anxiety

  Baseline, Week 4, Week 8, and Week 12

• Change in Self-Reported Well-being

  Baseline, Week 4, Week 8, and Week 12

• Change in Self-Reported Brain Fog

  Baseline, Week 4, Week 8, and Week 12

Study Arms (2)

Intervention (Beef Liver Supplement)

EXPERIMENTAL

Dietary Supplement: Intervention

Placebo Comparator

PLACEBO COMPARATOR

Dietary Supplement: Placebo

Interventions

Intervention DIETARY_SUPPLEMENT

Participants receive the Ancestral Supplements Grass Fed Beef Liver supplement (Grass Fed Liver \[Bovine\], 3000 mg per serving of 6 capsules) taken once daily, with a graduated dose escalation from 1 capsule/day over the first 18 days up to the full serving of 6 capsules/day, for 12 weeks.

Intervention (Beef Liver Supplement)

Placebo DIETARY_SUPPLEMENT

Participants receive a matched placebo product (microcrystalline cellulose and natural food color) taken once daily using the same dosing regimen as the intervention arm, for 12 weeks. The taste and appearance of the placebo are matched to the test product.

Placebo Comparator

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Be male or female
• Be aged 18-50
• Anyone experiencing issues regarding all of the following over the past four weeks: energy levels, mood, and mental clarity
• Anyone who is generally healthy - does not live with any uncontrolled chronic disease
• Anyone who is willing to maintain their current diet, sleep schedule, and activity level for the duration of the study
• Resides in the United States

You may not qualify if:

• Anyone with pre-existing chronic conditions that would prevent participants from adhering to the protocol, including oncological and psychiatric disorders
• Currently taking iron supplements or being treated for anemia
• Anyone currently taking oral contraceptives that contain iron
• Anyone currently taking vitamin A supplements, or supplements that contain vitamin A
• Anyone with any allergies or sensitivities to any of the study product ingredients
• Any women who are pregnant, breastfeeding, or trying to conceive (or who will be at any point during the study period)
• Anyone with hemochromatosis
• Anyone unwilling to follow the study protocol
• Has stopped using hormonal birth control in the past month
• Anyone who is vegan and/or does not consume animal products for any reason
• Anyone who is considered to be a heavy drinker (i.e. 8 or more alcoholic drinks per week for women or 15 or more alcoholic drinks per week for men)
• Planning on introducing any products or any new forms of prescription medication or supplements that target energy levels, mood, or mental clarity, during the study duration
• Currently partaking in another research study or will be partaking in any other research study at any point during this study's duration

Sponsors & Collaborators

• Ancestral Supplements, LLC: lead
• Citruslabs: collaborator

Study Sites (1)

Citruslabs

Las Vegas, Nevada, 89118, United States

Location

MeSH Terms

Conditions

Fatigue; Consciousness Disorders; Iron Deficiencies; Mental Fatigue

Interventions

Methods

Condition Hierarchy (Ancestors)

Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Neurocognitive Disorders; Mental Disorders; Iron Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Behavioral Symptoms; Behavior

Intervention Hierarchy (Ancestors)

Investigative Techniques

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 19, 2026
• First Posted: October 23, 2026
• Study Start: September 1, 2026
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: October 23, 2026

Record last verified: 2026-10

Locations

US (1)