Evaluation of Different Grafting Technique of Thin Gingival Phenotype With Delayed Dental Implants

NCT07892820 | Recruiting DMC

• 1 other identifier: FUE.(REC)(8)/1-2025
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

Implant dentistry has become a fundamental aspect of modern dental practice, with its success now determined by more than just Osseo integration. Various factors play a critical role in the long-term success of dental implants, one of the most important being the stability of the peri-implant soft tissues, which are essential for maintaining both function and aesthetics. This study aims to compare the outcomes of sub epithelial connective tissue grafts and de-epithelialized connective tissue grafts in conjunction with delayed implant placement.

Conditions

Implant Dentistry; Connective Tissue Graft

Outcome Measures

Primary Outcomes (1)

• Gingival index

  Soft tissue healing clinical examination

  baseline, after 6 months

Secondary Outcomes (1)

• Bone Density

  baseline, after 6 months

Study Arms (2)

De-epithelized connective tissue graft with thin gingival phenotype with delayed implant placement.

EXPERIMENTAL

Procedure: De-epithelized connective tissue graft

Sub-epithelized connective tissue graft

ACTIVE COMPARATOR

Procedure: Sub-epithelized connective tissue graft

Interventions

De-epithelized connective tissue graft PROCEDURE

A free gingival graft will be harvested, de-epithelialized extra-orally, producing a 1.5 mm thick connective tissue graft. The graft will be inserted into the buccal pouch and will be sutured with resorbable sutures. Gel foam will be placed in the donor site and sutured, with a stent fixed in place.

De-epithelized connective tissue graft with thin gingival phenotype with delayed implant placement.

Sub-epithelized connective tissue graft PROCEDURE

A free gingival graft will be harvested,and sub-epithelized intra-orally, producing a 1.5 mm thick connective tissue graft. The graft will be inserted into the buccal pouch and will be sutured with resorbable sutures. Gel foam will be placed in the donor site and sutured, with a stent fixed in place.

Sub-epithelized connective tissue graft

Eligibility Criteria

• Age: 20 Years - 50 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Thin gingival phenotype \< 1.5mm.\[6\]
• Medical free.
• Single edentulous area.
• Age range is between 20 to 50 years.
• Gingival recession.
• Free from any periodontal disease.
• Positive patient's acceptance for participating in the study.
• Patients able to sign informed consent.
• Non-smokers.
• Moderate palatal vault.
• Thickness of palatal graft not \<2mm.
• Width of bone not \<8mm.

You may not qualify if:

• Psychologically disturbed patients.
• Patients with a history of allergy to any medication used in the study were excluded.
• Osteoporosis.
• Parafunctional habit.
• Patients taking anticoa
• Gulant therapy.

Sponsors & Collaborators

• Future University in Egypt: lead

Study Sites (1)

Future University in Egypt

Cairo, Egypt

RECRUITING

Central Study Contacts

Hossam Rushdy Master Candidate, Bachelor Degree

CONTACT

+20 11 55436000; Hosam.Roshdy.1996@hotmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Master Degree Candidate in Periodontology Department -Faculty of Oral and Dental Medicine - Future university in Egypt

Study Record Dates

• First Submitted: October 18, 2026
• First Posted: October 23, 2026
• Study Start: January 30, 2025
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): January 30, 2027
• Last Updated: October 23, 2026

Record last verified: 2026-10

Locations

EG (1)