Efficacy of Seated Physical Activity INtervention(SPIN) for Wheelchair Users With Multiple Sclerosis

NCT07891520 | Not Yet Recruiting

• 2 other identifiers: HSC-SPH-26-0828RG-2512-45664
• Study Type: interventional
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to assess changes in the outcome of exercise behavior between the SPIN exercise-training condition and the WEllness for Longevity Living (WELL) attention/contact wellness control condition and to examine differences in exercise behavior, functioning, disability, and health between the SPIN and WELL conditions

Conditions

Multiple Sclerosis

Keywords

exercise

Outcome Measures

Primary Outcomes (2)

• Change in self reported total minutes per week of moderate-to-vigorous physical activity (MVPA)

  Baseline , 16 weeks.

• Change in strength training, assessed by the Leisure Time Physical Activity Questionnaire for People with Disabilities (LTPAQ-D)

  Participants report the number of days and average minutes per day spent in mild-, moderate-, and vigorous-intensity aerobic activities during the previous 7 days. Weekly minutes are calculated separately for each intensity and summed to obtain total aerobic physical activity, expressed in minutes per week. Higher values indicate greater participation in leisure-time aerobic physical activity

  Baseline , 16 weeks

Secondary Outcomes (5)

• Change in device-measured exercise behavior

  Baseline , 16 weeks

• Change in Upper-limb function as assessed by the Nine-Hole Peg Test

  Baseline , 16 weeks

• Change in Upper-limb function as assessed by the Grip strength using the hand dynamometer

  Baseline , 16 weeks

• Change in Disability / Activities of Daily Living ( ADL) as assessed by the Barthel Index score

  Baseline , 16 weeks

• Change in Health-Related Quality of Life as assessed by the Multiple Sclerosis Impact Scale-29 (MSIS-29)

  Baseline , 16 weeks

Study Arms (2)

SPIN exercise-training condition

EXPERIMENTAL

Behavioral: SPIN exercise-training

WELL attention/contact wellness control condition

ACTIVE COMPARATOR

Behavioral: Control Condition (WELL)

Interventions

SPIN exercise-training BEHAVIORAL

Participants complete three days of both modalities each week, with at least one day of rest between resistance sessions. For the first two weeks, all participants begin at 10-minute aerobic sessions and 1 set of 10 repetitions of five resistance exercises. The aerobic goal is to progress to 30-minute sessions (90 minutes/week) using a cycle (arm) ergometer; the resistance goal is 2 sets of 15 repetitions of 10 exercises (\~60 minutes/week). After two weeks, participants select one of three progression tracks (white, blue, or orange) with their coach. The final overall goal is 30 minutes of aerobic exercise plus 10 resistance exercises for two sets of 15 repetitions, three days per week (\~150 minutes/week of MVPA).The total time is 16 weeks.

SPIN exercise-training condition

Control Condition (WELL) BEHAVIORAL

The WELL attention/contact control mirrors SPIN in coaching schedule and materials but focuses on health behaviors other than physical activity (diet, emotions, stress, sleep, fatigue, and falls). It is based on Social Cognitive Theory (SCT) principles and integrates National Multiple Sclerosis Society (NMSS) wellness resources. WELL includes 12 newsletters (Diet, Sleep, Stress, Balance, Cognition, and Fatigue).

WELL attention/contact wellness control condition

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Diagnosis of multiple sclerosis (MS).
• Self-reported use of a wheelchair (manual wheelchair, power wheelchair, or scooter) ≥50% of the time.
• Relapse-free for the past 30 days.
• Godin Leisure Time Exercise Questionnaire Health Contribution Score \<14 units (i.e., not meeting current physical activity guidelines).

You may not qualify if:

• An MS relapse within the past 30 days

Sponsors & Collaborators

• The University of Texas Health Science Center, Houston: lead
• National Multiple Sclerosis Society: collaborator

Study Sites (1)

The University of Texas Health Science Center at Houston

Houston, Texas, 77030, United States

Location

MeSH Terms

Conditions

Multiple Sclerosis; Motor Activity

Condition Hierarchy (Ancestors)

Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases; Behavior

Study Officials

• Stephanie L Silveira, PhD

  The University of Texas Health Science Center, Houston

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Stephanie L Silveira, PhD

CONTACT

(713) 500-9484; Stephanie.L.Silveira@uth.tmc.edu

Rachel Barnes

CONTACT

(713) 500 9464; Rachel.Barnes.1@uth.tmc.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: October 16, 2026
• First Posted: October 23, 2026
• Study Start (Estimated): January 4, 2027
• Primary Completion (Estimated): January 2, 2029
• Study Completion (Estimated): February 5, 2029
• Last Updated: October 23, 2026

Record last verified: 2026-10

Locations

US (1)