NCT07555015

Brief Summary

The goal of this study is to learn how a six-week, nurse-led virtual group program may affect meaning in life and quality of life in adult women living with Multiple Sclerosis (MS). Many people with MS describe changes in identity, purpose, and daily life. This study will help researchers understand whether a structured group program can support women as they explore meaning and purpose while living with MS. The main questions this study aims to answer are:

  • How does the program affect how participants search for meaning in life?
  • How does it affect their sense of life purpose or direction?
  • How does it affect their overall quality of life? This study uses a single-group design. All participants will take part in the six-week virtual group program. The program is led by a registered nurse and focuses on guided reflection, values exploration, and group discussion. Participants will:
  • Attend one virtual group session each week for six weeks
  • Take part in guided discussions and reflection exercises
  • Complete three online surveys: one before the program begins, one at Week 3, and one after Week 6
  • Use a computer, tablet, or phone to join all virtual sessions The surveys will ask about:
  • How participants search for meaning in their lives
  • How much purpose and direction they feel
  • Their physical and emotional quality of life There are no medications, invasive procedures, or in-person visits in this study.

Trial Health

65
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
40

participants targeted

Target at P25-P50 for not_applicable multiple-sclerosis

Timeline
3mo left

Started Jun 2026

Shorter than P25 for not_applicable multiple-sclerosis

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

April 21, 2026

Completed
7 days until next milestone

First Posted

Study publicly available on registry

April 28, 2026

Completed
1 month until next milestone

Study Start

First participant enrolled

June 1, 2026

Expected
3 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 1, 2026

Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2026

Last Updated

May 1, 2026

Status Verified

April 1, 2026

Enrollment Period

3 months

First QC Date

April 21, 2026

Last Update Submit

April 27, 2026

Conditions

Multiple Sclerosis

Keywords

Multiple SclerosisQuality of LifeMeaning in LifeNurse-led behavioral interventionPurpose-building interventionMeaning-centered interventionvirtual group interventionNurse-guidedPsychological adaptationsPurpose in life

Outcome Measures

Primary Outcomes (3)

  • Change in Search for Meaning (Meaning in Life Questionnaire - Search Subscale)

    The Search for Meaning subscale of the Meaning in Life Questionnaire (MLQ-S) assesses the degree to which individuals are actively seeking purpose or meaning in their lives. Scores range from 5 to 35, with higher scores indicating a greater search for meaning. The outcome is the change in MLQ-S scores from Baseline to Week 3 and Week 6.

    Baseline, Week 3, Week 6

  • Change in Quality of Life (Multiple Sclerosis Quality of Life-29 Scale)

    Quality of life will be assessed using the Multiple Sclerosis Quality of Life-29 (MSQOL-29), which generates composite scores for physical and mental well-being. Subscale scores are standardized from 0 to 100, with higher scores indicating better quality of life. The outcome is the change in MSQOL-29 composite scores from Baseline to Week 3 and Week 6.

    Baseline, Week 3, Week 6

  • Change in Presence of Meaning (Meaning in Life Questionnaire - Presence Subscale)

    The Presence of Meaning subscale of the Meaning in Life Questionnaire (MLQ-P) measures the extent to which individuals perceive their lives as meaningful. Scores range from 5 to 35, with higher scores indicating greater perceived meaning. The outcome is the change in MLQ-P scores from Baseline to Week 3 and Week 6.

    Baseline, Week 3, Week 6

Study Arms (1)

Nurse-Led Virtual Purpose-Building Intervention

EXPERIMENTAL
Behavioral: Nurse-Led Purpose-Building Intervention

Interventions

Nurse-Led Purpose-Building InterventionBEHAVIORAL

The Nurse-Led Virtual Purpose-Building Intervention is a six-week, synchronous behavioral program delivered in small groups through a secure videoconferencing platform. Sessions are facilitated by a registered nurse trained in the study protocol. Each weekly session lasts 60 minutes and follows a standardized structure that includes: (1) an opening reflective prompt or grounding exercise, (2) guided group dialogue focused on meaning, identity, and purpose in the context of living with Multiple Sclerosis, (3) a brief integrative activity such as journaling or values-based reflection, and (4) a closing synthesis. The intervention emphasizes person-centered exploration, reflective engagement, and meaning-making rather than clinical counseling or symptom management. No medical treatments, diagnostic procedures, or therapeutic techniques are used. Fidelity to session structure is supported through a facilitator manual and weekly documentation.

Nurse-Led Virtual Purpose-Building Intervention

Eligibility Criteria

Age18 Years+
Sexfemale(Gender-based eligibility)
Gender Eligibility DetailsEligibility is limited to individuals who self-identify as women
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • women
  • over the age of 18
  • a diagnosis of Multiple Sclerosis (Primary Progressive, Relapsing-Remitting, Secondary Progressive)
  • access to a device with internet capability as well as audio and video functions
  • comfortable reading, writing, and participating in group discussions in English

You may not qualify if:

  • currently enrolled (or have been enrolled within the last 4 weeks) of any similar group based intervention therapy (logotherapy, Acceptance and Commitment Therapy, or Cognitive Behavioral Therapy)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Multiple Sclerosis

Condition Hierarchy (Ancestors)

Demyelinating Autoimmune Diseases, CNSAutoimmune Diseases of the Nervous SystemNervous System DiseasesDemyelinating DiseasesAutoimmune DiseasesImmune System Diseases

Study Officials

  • Chanam Shin, PhD

    Texas Woman's University

    STUDY CHAIR

Central Study Contacts

Lisa Kelly

CONTACT

254-368-7638lkelly5@twu.edu

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
SUPPORTIVE CARE
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

April 21, 2026

First Posted

April 28, 2026

Study Start (Estimated)

June 1, 2026

Primary Completion (Estimated)

September 1, 2026

Study Completion (Estimated)

September 1, 2026

Last Updated

May 1, 2026

Record last verified: 2026-04

Data Sharing

IPD Sharing
Will not share

Individual participant data will not be shared due to the small sample size and risk of re-identification. However, de-identified aggregate results will be shared publicly through publications and conference presentations.