Multimodal Rehabilitation and Balance Assessment in Parkinson's Disease

NCT07887802 | Completed

• 1 other identifier: IMU-PD-2023-0725
• Study Type: interventional
• Target: 18
• Locations: 1 country
• Sites: 1

Brief Summary

This study aimed to investigate the relationship between instrumented balance measurements and clinical balance assessments in individuals with Parkinson's disease and to evaluate changes in balance and functional mobility following a 12-week multimodal rehabilitation program. Eighteen individuals with Parkinson's disease participated in this prospective, single-group study. All participants received a rehabilitation program that included balance exercises, aerobic exercise, and balance training using the Korebalance system. The program was conducted twice weekly for 12 weeks. Balance was assessed using the Korebalance system and the Berg Balance Scale (BBS). Functional mobility was evaluated using the Timed Up and Go (TUG) test. Assessments were performed before and after the rehabilitation program. The study examined whether instrumented balance measurements were associated with clinical balance performance and whether balance and functional mobility changed following rehabilitation.

Conditions

Parkinson Disease (PD)

Keywords

Parkinson's Disease; Balance Rehabilitation; Korebalance; Instrumented Balance Assessment; Berg Balance Scale; Timed Up and Go; Multimodal Rehabilitation; Postural Stability

Outcome Measures

Primary Outcomes (2)

• Change in Static Korebalance Score

  Static balance was assessed using the Korebalance Premiere-19 system. Measurements were obtained at baseline and after the 12-week multimodal rehabilitation program. Lower scores indicate better balance performance. Change was calculated as the post-intervention score minus the baseline score.

  Baseline and Week 12

• Change in Dynamic Korebalance Score

  Dynamic balance was assessed using the Korebalance Premiere-19 system. Measurements were obtained at baseline and after the 12-week multimodal rehabilitation program. Lower scores indicate better balance performance. Change was calculated as the post-intervention score minus the baseline score.

  Baseline and Week 12

Secondary Outcomes (2)

• Change in Berg Balance Scale Score

  Baseline and Week 12

• Change in Timed Up and Go Test Time

  Baseline and Week 12

Study Arms (1)

Multimodal Rehabilitation Group

EXPERIMENTAL

Participants with Parkinson's disease received a 12-week supervised multimodal rehabilitation program, conducted twice weekly. The intervention included progressive balance exercises, functional mobility training, dual-task activities, moderate-intensity aerobic exercise, and Korebalance-assisted balance training. All participants received the same intervention, with no control group.

Behavioral: Multimodal Rehabilitation Program

Interventions

Multimodal Rehabilitation Program BEHAVIORAL

Participants received a supervised multimodal rehabilitation program twice weekly for 12 weeks (24 sessions). The program included approximately 10 minutes of warm-up exercises, 20 minutes of progressive balance training, and 20 minutes of moderate-intensity aerobic exercise using a treadmill or stationary bicycle. Balance exercises included static and dynamic balance tasks, multidirectional stepping, functional mobility activities, turning, and dual-task training. Additional balance training was performed using the Korebalance Premiere-19 system. Exercise intensity was generally maintained at a Borg Rating of Perceived Exertion of 11-14. Exercises were individually progressed according to participant ability and safety.

Multimodal Rehabilitation Group

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adults aged 18 years or older.
• Diagnosis of Parkinson's disease.
• Hoehn and Yahr stages 1-3.
• Sufficient cognitive function to understand and follow instructions during assessments and rehabilitation.
• Ability to participate in the rehabilitation program.
• Provision of written informed consent.

You may not qualify if:

• Advanced Parkinson's disease (Hoehn and Yahr stages 4-5).
• Significant cognitive impairment that could interfere with participation or assessment.
• Other neurological disorders affecting balance or mobility.
• History of surgery within the preceding six months.
• Severe or uncontrolled systemic diseases that could interfere with safe participation in the rehabilitation program.
• Refusal or inability to provide informed consent.

Sponsors & Collaborators

• Bilinç Doğruöz Karatekin: lead

Study Sites (1)

Goztepe Prof. Dr. Suleyman Yalcin City Hospital

Istanbul, 34722, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Parkinson Disease

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Cihat Kurt, MD

Model Details: A prospective, single-center, single-group pre-post interventional study. All participants received the same 12-week multimodal rehabilitation program. Outcomes were assessed at baseline and following completion of the intervention. No control group was included.

Study Record Dates

• First Submitted: October 15, 2026
• First Posted: October 21, 2026
• Study Start: February 5, 2024
• Primary Completion: August 17, 2026
• Study Completion: August 17, 2026
• Last Updated: October 21, 2026

Record last verified: 2026-10

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)