Circuit Breathing Exercise on Smoking Cessation Among Youth E-Cigarette Users

NCT07886099 | Recruiting DMC

• 1 other identifier: EX PHYSIO SPSC 14
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to investigate the acute effects of a circuit breathing intervention on nicotine withdrawal symptoms and respiratory parameters among youth who use e-cigarettes.

Conditions

E Cigarette Use

Keywords

Circuit breathing; Nicotine withdrawal symptoms; E Cigarette; Fractional exhaled nitric oxide; Respiratory Function

Outcome Measures

Primary Outcomes (2)

• E-cigarette Dependence

  E-cigarette dependence will be assessed using the Penn State Electronic Cigarette Dependence Index, adapted by Sornsenee et al. (2025). The questionnaire consists of 10 items, with a maximum total score of 20. Scores are interpreted as follows: 0-3 indicates no e-cigarette dependence, 4-8 indicates low dependence, 9-12 indicates moderate dependence, and 13 or higher indicates high dependence.

  Baseline for demographic data.

• Nicotine Withdrawal Symptoms

  Nicotine withdrawal symptoms will be assessed using the Thai version of the Minnesota Nicotine Withdrawal Scale-Revised (MNWS) (Hughes \& Hatsukami, 2008), translated by Sirirat Kanokururot and Sunida Preechawong (2010). This self-report questionnaire measures the perceived severity of nicotine withdrawal symptoms. It consists of 9 items rated on a 5-point scale ranging from 0 (no symptoms) to 4 (severe symptoms). The total score ranges from 0 to 36, with a score of 0 indicating no nicotine withdrawal symptoms and a score of 36 indicating the most severe nicotine withdrawal symptoms.

  Immediately before and immediately after each breathing intervention session.

Secondary Outcomes (2)

• Fractional Exhaled Nitric Oxide (FeNO)

  Immediately before and immediately after each breathing intervention session.

• Peak Nasal Inspiratory Flow (PNIF)

  Immediately before and immediately after each breathing intervention session.

Study Arms (3)

Circuit Breathing

EXPERIMENTAL

Other: Circuit breathing

Diaphragmatic Breathing

EXPERIMENTAL

Other: Diaphragmatic Breathing

Normal Breathing

EXPERIMENTAL

Other: Normal Breathing Condition

Interventions

Circuit breathing OTHER

The circuit breathing intervention consists of five stations: paper suction using a straw, blowing a toy pinwheel, incentive spirometry, balloon blowing, and weighted diaphragmatic breathing. Participants will rest for 1 minute between stations.

Circuit Breathing

Diaphragmatic Breathing OTHER

The diaphragmatic breathing exercise will consist of inhaling through the nose for 4 seconds and exhaling through the nose for 6 seconds, continuously for 10 minutes per set. Participants will rest for 1 minute between sets and complete a total of 3 sets.

Diaphragmatic Breathing

Normal Breathing Condition OTHER

Participants will breathe normally through the nose without deliberately controlling the rate, rhythm, or depth of breathing. Breathing will remain at each participant's natural pace for approximately 30 minutes.

Normal Breathing

Eligibility Criteria

• Age: 15 Years - 25 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Male or female aged 15-25 years.
• Regular e-cigarette use for at least six months and current e-cigarette use, defined as use on at least one day per week or at least 10 puffs per day during the past 30 days.
• Not regularly physically active, defined as exercising fewer than two times per week during the preceding six months.
• Able to understand instructions, communicate effectively, and cooperate with the research procedures.
• No history of cardiovascular disease or respiratory disease, such as asthma or chronic obstructive pulmonary disease.
• No uncontrolled hypertension. Participants with controlled hypertension must have resting blood pressure ≤140/90 mmHg.
• Able to move independently without assistance or assistive devices.
• Willing to participate and provide informed consent.
• For participants younger than 18 years, consent from a parent or legally authorized representative is required.

You may not qualify if:

• Development of an illness, injury, or other circumstance that prevents continued participation.
• Withdrawal of consent or unwillingness to continue participation.
• Current use of illicit drugs or other tobacco/nicotine products, including conventional cigarettes, shisha/hookah, roll-your-own tobacco, or other nicotine-containing products.

Sponsors & Collaborators

• Chulalongkorn University: lead

Study Sites (1)

Faculty of Sports Science, Chulalongkorn University

Bangkok, Bangkok, 10330, Thailand

RECRUITING

MeSH Terms

Conditions

Vaping; Respiratory Aspiration

Condition Hierarchy (Ancestors)

Smoking; Behavior; Respiration Disorders; Respiratory Tract Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Wannaporn Tongtako, Ph.D.

CONTACT

0879823131; wannaporn.t@chula.ac.th

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: October 10, 2026
• First Posted: October 21, 2026
• Study Start: August 15, 2026
• Primary Completion: October 15, 2026
• Study Completion (Estimated): October 30, 2026
• Last Updated: October 21, 2026

Record last verified: 2026-10

Data Sharing

• IPD Sharing: Will not share

Locations

TH (1)