NCT07866703|Not Yet Recruiting
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Sponsor study identifier
observational
60
1 country
1
Study Start
September 26, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
October 2, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
December 30, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
The aim of this study is to investigate whether there are differences in muscle activation of the first dorsal interosseous (FDI) and the abductor pollicis longus (APL) between individuals with and without thumb trapeziopometacarpal joint osteoarthritis (OA TMC) during the performance of activities of daily living (ADL). The FDI muscle has been identified as a key stabilizer of the thumb TMC joint. However, scientific literature lacks information regarding the activation of the FDI and the APL during ADL, particularly in comparison with healthy individuals. OA TMC can lead to pain, reduced thumb strength, impaired hand function, and difficulty performing ADL. Determining whether differences in muscle activation patterns exist between individuals with and without OA TMC is crucial for understanding how this condition affects hand function and for guiding more specific and effective rehabilitation strategies. Participants will perform six standardized functional tasks simulating everyday activities: turning a key to open, turning a key to close, picking up a coin, writing, squeezing a tube of toothpaste, and holding a glass of water. Muscle activity will be recorded using surface electromyography (sEMG) during all tasks. Adults aged 30 years and older, both men and women, with thumb CMC osteoarthritis and healthy controls without osteoarthritis will be invited to participate. Researchers will measure the activation patterns of the FDI and APL muscles during the ADL, with the aim of identifying differences between both groups and providing evidence to guide the rehabilitation of patients with thumb base osteoarthritis.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 30, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
September 26, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
September 27, 2026
Actual (reported)October 2, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
October 8, 2026
Actual (reported)December 30, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Surface electromyographic amplitude of the First Dorsal Interosseous muscle.
Mean surface electromyographic amplitude of the First Dorsal Interosseous muscle recorded during each of the 6 activities of daily living
Day 1
Surface electromyographic amplitude of the Abductor Pollicis Longus muscle
Mean surface electromyographic amplitude of the Abductor Pollicis Longus muscle recorded during each of the 6 activities of daily living.
Day 1
Adults aged 18 years and older with a clinical diagnosis of thumb trapeziometacarpal (TMC) osteoarthritis. Participants will perform six standardized functional tasks simulating activities of daily living while surface electromyography (sEMG) of the first dorsal interosseous (FDI) and abductor pollicis longus (APL) muscles is recorded. No pharmacological or physical intervention is administered; this is an observational measurement of muscle activation during functional tasks.
Adults aged 18 years and older without musculoskeletal or neurological disorders affecting the hand, and without thumb TMC osteoarthritis. Participants will perform the same six standardized functional tasks simulating activities of daily living while surface electromyography (sEMG) of the FDI and APL muscles is recorded, to serve as a comparison group.
The study population will include adults aged 18 years and older, both men and women, divided into two groups. The first group will consist of individuals with a clinical diagnosis of thumb trapeziometacarpal osteoarthritis, and the second group will consist of healthy controls without musculoskeletal or neurological disorders affecting the hand.
Universidad de Málaga
Málaga, Málaga, 29071, Spain
Kerkhof FD, Deleu G, D'Agostino P, Vereecke EE. Subject-specific thumb muscle activity during functional tasks of daily life. J Electromyogr Kinesiol. 2016 Oct;30:131-6. doi: 10.1016/j.jelekin.2016.06.009. Epub 2016 Jul 1.
Brorsson S, Nilsdotter A, Thorstensson C, Bremander A. Differences in muscle activity during hand-dexterity tasks between women with arthritis and a healthy reference group. BMC Musculoskelet Disord. 2014 May 15;15:154. doi: 10.1186/1471-2474-15-154.
First Submitted
September 27, 2026
First Posted
October 8, 2026
Study Start
September 26, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
Use of a Treated, Devitalized and Sterile Umbilical Cord Amniotic Membrane in the Treatment of Trapeziometacarpal Osteoarthritis
Contact the study team to confirm eligibility.
Haugen IK, Englund M, Aliabadi P, Niu J, Clancy M, Kvien TK, Felson DT. Prevalence, incidence and progression of hand osteoarthritis in the general population: the Framingham Osteoarthritis Study. Ann Rheum Dis. 2011 Sep;70(9):1581-6. doi: 10.1136/ard.2011.150078. Epub 2011 May 27.
Sodha S, Ring D, Zurakowski D, Jupiter JB. Prevalence of osteoarthrosis of the trapeziometacarpal joint. J Bone Joint Surg Am. 2005 Dec;87(12):2614-2618. doi: 10.2106/JBJS.E.00104.
Villafane JH, Valdes K. Combined thumb abduction and index finger extension strength: a comparison of older adults with and without thumb carpometacarpal osteoarthritis. J Manipulative Physiol Ther. 2013 May;36(4):238-44. doi: 10.1016/j.jmpt.2013.05.004. Epub 2013 May 27.
Cantero-Tellez R, Algar LA, Valdes KA, Naughton N. Clinical effects of proprioceptive thumb exercise for individuals with carpometacarpal joint osteoarthritis: A randomized controlled trial. J Hand Ther. 2022 Jul-Sep;35(3):358-366. doi: 10.1016/j.jht.2022.06.009. Epub 2022 Aug 23.
Osteras N, Hagen KB, Grotle M, Sand-Svartrud AL, Mowinckel P, Kjeken I. Limited effects of exercises in people with hand osteoarthritis: results from a randomized controlled trial. Osteoarthritis Cartilage. 2014 Sep;22(9):1224-33. doi: 10.1016/j.joca.2014.06.036. Epub 2014 Jul 5.
McVeigh KH, Kannas SN, Ivy CC, Garner HW, Barnes CS, Heckman MG, Brushaber DE, Murray PM. Dynamic stabilization home exercise program for treatment of thumb carpometacarpal osteoarthritis: A prospective randomized control trial. J Hand Ther. 2022 Jul-Sep;35(3):435-446. doi: 10.1016/j.jht.2021.06.002. Epub 2021 Jul 24.
Deveza LA, Hunter DJ, Wajon A, Bennell KL, Vicenzino B, Hodges P, Eyles JP, Jongs R, Riordan EA, Duong V, Min Oo W, O'Connell R, Meneses SR. Efficacy of combined conservative therapies on clinical outcomes in patients with thumb base osteoarthritis: protocol for a randomised, controlled trial (COMBO). BMJ Open. 2017 Jan 12;7(1):e014498. doi: 10.1136/bmjopen-2016-014498.
Tossini NB, Melo CS, Braz de Oliveira MP, Moreira RFC, Serrao PRMDS. Effect of physical therapy interventions in individuals with primary thumb carpometacarpal osteoarthritis: a systematic review and meta-analysis. Disabil Rehabil. 2024 Dec;46(26):6251-6265. doi: 10.1080/09638288.2024.2325652. Epub 2024 Mar 7.
Ahern M, Skyllas J, Wajon A, Hush J. The effectiveness of physical therapies for patients with base of thumb osteoarthritis: Systematic review and meta-analysis. Musculoskelet Sci Pract. 2018 Jun;35:46-54. doi: 10.1016/j.msksp.2018.02.005. Epub 2018 Feb 21.
Whitford M, Kukulka CG. Task-related variations in the surface EMG of the human first dorsal interosseous muscle. Exp Brain Res. 2011 Nov;215(2):101-13. doi: 10.1007/s00221-011-2875-9. Epub 2011 Oct 1.
McGee C, O'Brien V, Van Nortwick S, Adams J, Van Heest A. First dorsal interosseous muscle contraction results in radiographic reduction of healthy thumb carpometacarpal joint. J Hand Ther. 2015 Oct-Dec;28(4):375-80; quiz 381. doi: 10.1016/j.jht.2015.06.002. Epub 2015 Jun 27.
October 2, 2026
This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
December 30, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
October 8, 2026
Record last verified: 2026-10
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