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First Dorsal Interosseous Exercises Reveal Altered Recruitment for the FDI and APL in Thumb Carpometacarpal Osteoarthritis. A Cross-Sectional EMG Study
Sponsor study identifier
observational
30
1 country
1
Study Start
February 28, 2026
Actual (reported)Primary Completion
July 28, 2026
Actual (reported)Study Completion
August 28, 2026
Actual (reported)The aim of this study is to investigate whether there are differences in muscle activation of the First Dorsal Interosseous (FDI) and the Abductor Pollicis Longus (APL) between individuals with and without trapeziometacarpal osteoarthritis (TMC OA) of the thumb. The study also seeks to identify which exercises are most effective for activating these muscles, in order to inform rehabilitation strategies for patients. The FDI has been defined as a key stabilizer of the thumb TMC joint. However, the literature reports various protocols for FDI activation and limited information on APL behavior during these exercises. OA TMC of the thumb can cause pain, decreased thumb strength, impaired hand function, and difficulty performing activities of daily living (ADLs). Appropriate rehabilitation is essential to maintain muscle function, limit joint degeneration, and improve hand performance; however, the exercises that optimally activate the FDI and APL muscles are not yet established. Participants will perform a series of standardized exercises and functional tasks designed to activate the FDI and APL muscles. Exercises include FDI strengthening with elastic bands in different hand positions (palmar and ulnar support), as well as exercises with the thumb in greater abduction. Functional tasks simulating everyday activities (e.g., turning a key, picking up a coin, writing, squeezing a tube of toothpaste, and holding a glass of water) will also be performed. Muscle activity will be recorded using surface electromyography (sEMG) during all tasks. Adults aged 40 years and older, both men and women, with TMC osteoarthritis and healthy controls without osteoarthritis will be invited to participate. Researchers will measure the activation patterns of the FDI and APL muscles during FDI activation exercises . The study aims to identify exercises that optimally activate these muscles, providing evidence to guide the rehabilitation of patients with thumb base osteoarthritis.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
August 28, 2026
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
February 4, 2026
Actual (reported)February 19, 2026
Actual (reported)February 28, 2026
Actual (reported)July 28, 2026
Actual (reported)August 28, 2026
Actual (reported)Surface electromyographic amplitude of the First Dorsal Interosseous muscle.
Mean surface electromyographic amplitude of the First Dorsal Interosseous muscle recorded during each of the 6 standardized exercises
Day 1
Surface electromyographic amplitude of the Abductor Pollicis Longus muscle
Mean surface electromyographic amplitude of the Abductor Pollicis Longus muscle recorded during each of the 6 standardized exercises
Day 1
Adults aged 18 years and older with a clinical diagnosis of thumb trapeziometacarpal (TMC) osteoarthritis. Participants will perform six standardized exercises designed to selectively activate the first dorsal interosseous (FDI) muscle, while surface electromyography (sEMG) of the FDI and abductor pollicis longus (APL) muscles is recorded. No pharmacological or physical intervention is administered beyond the exercises themselves; this is an observational measurement of muscle activation during standardized exercise performance.
Participants were adults with a clinical diagnosis of thumb carpometacarpal osteoarthritis, recruited from the Universidad de Málaga.
Universidad de Málaga
Málaga, Málaga, 29071, Spain
McGee C, O'Brien V, Van Nortwick S, Adams J, Van Heest A. First dorsal interosseous muscle contraction results in radiographic reduction of healthy thumb carpometacarpal joint. J Hand Ther. 2015 Oct-Dec;28(4):375-80; quiz 381. doi: 10.1016/j.jht.2015.06.002. Epub 2015 Jun 27.
Bertozzi L, Valdes K, Vanti C, Negrini S, Pillastrini P, Villafane JH. Investigation of the effect of conservative interventions in thumb carpometacarpal osteoarthritis: systematic review and meta-analysis. Disabil Rehabil. 2015;37(22):2025-43. doi: 10.3109/09638288.2014.996299. Epub 2015 Jan 5.
30 participants (actual enrollment reported by the registry).
First Submitted
February 4, 2026
First Posted
February 19, 2026
Study Start
February 28, 2026
Actual (reported)Contact the study team to confirm eligibility.
Ahern M, Skyllas J, Wajon A, Hush J. The effectiveness of physical therapies for patients with base of thumb osteoarthritis: Systematic review and meta-analysis. Musculoskelet Sci Pract. 2018 Jun;35:46-54. doi: 10.1016/j.msksp.2018.02.005. Epub 2018 Feb 21.
Tossini NB, Melo CS, Braz de Oliveira MP, Moreira RFC, Serrao PRMDS. Effect of physical therapy interventions in individuals with primary thumb carpometacarpal osteoarthritis: a systematic review and meta-analysis. Disabil Rehabil. 2024 Dec;46(26):6251-6265. doi: 10.1080/09638288.2024.2325652. Epub 2024 Mar 7.
Deveza LA, Hunter DJ, Wajon A, Bennell KL, Vicenzino B, Hodges P, Eyles JP, Jongs R, Riordan EA, Duong V, Min Oo W, O'Connell R, Meneses SR. Efficacy of combined conservative therapies on clinical outcomes in patients with thumb base osteoarthritis: protocol for a randomised, controlled trial (COMBO). BMJ Open. 2017 Jan 12;7(1):e014498. doi: 10.1136/bmjopen-2016-014498.
McVeigh KH, Kannas SN, Ivy CC, Garner HW, Barnes CS, Heckman MG, Brushaber DE, Murray PM. Dynamic stabilization home exercise program for treatment of thumb carpometacarpal osteoarthritis: A prospective randomized control trial. J Hand Ther. 2022 Jul-Sep;35(3):435-446. doi: 10.1016/j.jht.2021.06.002. Epub 2021 Jul 24.
Osteras N, Hagen KB, Grotle M, Sand-Svartrud AL, Mowinckel P, Kjeken I. Limited effects of exercises in people with hand osteoarthritis: results from a randomized controlled trial. Osteoarthritis Cartilage. 2014 Sep;22(9):1224-33. doi: 10.1016/j.joca.2014.06.036. Epub 2014 Jul 5.
Cantero-Tellez R, Algar LA, Valdes KA, Naughton N. Clinical effects of proprioceptive thumb exercise for individuals with carpometacarpal joint osteoarthritis: A randomized controlled trial. J Hand Ther. 2022 Jul-Sep;35(3):358-366. doi: 10.1016/j.jht.2022.06.009. Epub 2022 Aug 23.
Villafane JH, Valdes K. Combined thumb abduction and index finger extension strength: a comparison of older adults with and without thumb carpometacarpal osteoarthritis. J Manipulative Physiol Ther. 2013 May;36(4):238-44. doi: 10.1016/j.jmpt.2013.05.004. Epub 2013 May 27.
Sodha S, Ring D, Zurakowski D, Jupiter JB. Prevalence of osteoarthrosis of the trapeziometacarpal joint. J Bone Joint Surg Am. 2005 Dec;87(12):2614-2618. doi: 10.2106/JBJS.E.00104.
Haugen IK, Englund M, Aliabadi P, Niu J, Clancy M, Kvien TK, Felson DT. Prevalence, incidence and progression of hand osteoarthritis in the general population: the Framingham Osteoarthritis Study. Ann Rheum Dis. 2011 Sep;70(9):1581-6. doi: 10.1136/ard.2011.150078. Epub 2011 May 27.
Primary Completion
July 28, 2026
Actual (reported)Study Completion
August 28, 2026
Actual (reported)Last Updated
October 8, 2026
Record last verified: 2026-10
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