NCT07865013|Not Yet Recruiting
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Sponsor study identifier
interventional
100
0 countries
N/A
Study Start
January 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Primary Completion
December 2030
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
December 2030
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
This is a single-arm, minimal-risk, interventional behavioral clinical trial embedding structured transition support for adolescent and young adult (AYA) survivors of pediatric cancer transitioning into adult-focused survivorship care. Aims are to improve AYA transition from pediatric to adult survivorship care and to enhance AYA access to fertility education and care. Patient Participants will:
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 2030
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
September 17, 2026
Actual (reported)October 8, 2026
Actual (reported)January 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
December 2030
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
December 2030
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Primary outcome is transition success (Goal: 80% of referred)
Medical record abstraction will be used to collect detailed information on each participant's cancer history and follow-up care. This process will include extraction of key clinical data such as cancer diagnosis, dates of treatment, treatment location, and specific treatment modalities, including radiation and chemotherapy doses. Additional information on relapse history, occurrence of secondary malignancies, and adherence to COG screening recommendations will also be obtained. Data on subspecialty referrals, scheduled appointment dates, and attendance at those appointments will be recorded to assess patterns of care and follow-up.
Medical record abstraction at baseline and annually for 3 years.
Adolescent and young adult engagement and feedback
Assessed by structured interviews at 18 & 36 mo.
Participants will receive: 1. A pre-transition developmental needs assessment 2. Up to 2 years of AYA nurse navigation support
Participants will receive: 1. A pre-transition developmental needs assessment 2. Up to 2 years of AYA nurse navigation support
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Gorman JR, Drizin JH, Malcarne VL, Hsieh TC. Measuring the Multidimensional Reproductive Concerns of Young Adult Male Cancer Survivors. J Adolesc Young Adult Oncol. 2020 Dec;9(6):613-620. doi: 10.1089/jayao.2019.0146. Epub 2020 Apr 16.
Quinn GP, Bowman Curci M, Reich RR, Gwede CK, Meade CD; ENRICH/ECHO Working Group; Vadaparampil ST. Impact of a web-based reproductive health training program: ENRICH (Educating Nurses about Reproductive Issues in Cancer Healthcare). Psychooncology. 2019 May;28(5):1096-1101. doi: 10.1002/pon.5063. Epub 2019 Apr 5.
First Submitted
September 17, 2026
First Posted
October 8, 2026
Study Start
January 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Primary Completion
December 2030
Intervention for Chronic Insufficient Sleep in Young Adult Cancer Patients and Survivors
Adherence to Children's Oncology Group (COG) survivorship guidelines.
Will be assessed by medical record abstraction at baseline, and annually for 3 years.
Demographic and diversity-related factors of representation
Will be assessed at baseline and years 1-3.
Transition Readiness
Will be measured at baseline and years 1-3.
Health-Related Quality of Life
Will be measured at baseline and years 1-3.
Contact the study team to confirm eligibility.
de Souza JA, Yap BJ, Wroblewski K, Blinder V, Araujo FS, Hlubocky FJ, Nicholas LH, O'Connor JM, Brockstein B, Ratain MJ, Daugherty CK, Cella D. Measuring financial toxicity as a clinically relevant patient-reported outcome: The validation of the COmprehensive Score for financial Toxicity (COST). Cancer. 2017 Feb 1;123(3):476-484. doi: 10.1002/cncr.30369. Epub 2016 Oct 7.
Siembida EJ, Reeve BB, Zebrack BJ, Snyder MA, Salsman JM. Measuring health-related quality of life in adolescent and young adult cancer survivors with the National Institutes of Health Patient-Reported Outcomes Measurement Information System(R) : Comparing adolescent, emerging adult, and young adult survivor perspectives. Psychooncology. 2021 Mar;30(3):303-311. doi: 10.1002/pon.5577. Epub 2020 Oct 30.
Cella D, Riley W, Stone A, Rothrock N, Reeve B, Yount S, Amtmann D, Bode R, Buysse D, Choi S, Cook K, Devellis R, DeWalt D, Fries JF, Gershon R, Hahn EA, Lai JS, Pilkonis P, Revicki D, Rose M, Weinfurt K, Hays R; PROMIS Cooperative Group. The Patient-Reported Outcomes Measurement Information System (PROMIS) developed and tested its first wave of adult self-reported health outcome item banks: 2005-2008. J Clin Epidemiol. 2010 Nov;63(11):1179-94. doi: 10.1016/j.jclinepi.2010.04.011. Epub 2010 Aug 4.
Otth M, Denzler S, Koenig C, Koehler H, Scheinemann K. Transition from pediatric to adult follow-up care in childhood cancer survivors-a systematic review. J Cancer Surviv. 2021 Feb;15(1):151-162. doi: 10.1007/s11764-020-00920-9. Epub 2020 Jul 16.
Ehrhardt MJ, Friedman DN, Hudson MM. Health Care Transitions Among Adolescents and Young Adults With Cancer. J Clin Oncol. 2024 Feb 20;42(6):743-754. doi: 10.1200/JCO.23.01504. Epub 2024 Jan 9.
Marchak JG, Sadak KT, Effinger KE, Haardorfer R, Escoffery C, Kinahan KE, Freyer DR, Chow EJ, Mertens A. Transition practices for survivors of childhood cancer: a report from the Children's Oncology Group. J Cancer Surviv. 2023 Apr;17(2):342-350. doi: 10.1007/s11764-023-01351-y. Epub 2023 Mar 4.
Hudson MM, Bhatia S, Casillas J, Landier W; SECTION ON HEMATOLOGY/ONCOLOGY, CHILDREN'S ONCOLOGY GROUP, AMERICAN SOCIETY OF PEDIATRIC HEMATOLOGY/ONCOLOGY. Long-term Follow-up Care for Childhood, Adolescent, and Young Adult Cancer Survivors. Pediatrics. 2021 Sep;148(3):e2021053127. doi: 10.1542/peds.2021-053127.
Landier W, Armenian S, Bhatia S. Late effects of childhood cancer and its treatment. Pediatr Clin North Am. 2015 Feb;62(1):275-300. doi: 10.1016/j.pcl.2014.09.017. Epub 2014 Oct 18.
Robison LL, Armstrong GT, Boice JD, Chow EJ, Davies SM, Donaldson SS, Green DM, Hammond S, Meadows AT, Mertens AC, Mulvihill JJ, Nathan PC, Neglia JP, Packer RJ, Rajaraman P, Sklar CA, Stovall M, Strong LC, Yasui Y, Zeltzer LK. The Childhood Cancer Survivor Study: a National Cancer Institute-supported resource for outcome and intervention research. J Clin Oncol. 2009 May 10;27(14):2308-18. doi: 10.1200/JCO.2009.22.3339. Epub 2009 Apr 13.
Oeffinger KC, Mertens AC, Sklar CA, Kawashima T, Hudson MM, Meadows AT, Friedman DL, Marina N, Hobbie W, Kadan-Lottick NS, Schwartz CL, Leisenring W, Robison LL; Childhood Cancer Survivor Study. Chronic health conditions in adult survivors of childhood cancer. N Engl J Med. 2006 Oct 12;355(15):1572-82. doi: 10.1056/NEJMsa060185.
Planned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
December 2030
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
October 8, 2026
Record last verified: 2026-10
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