LONGEVITY-NEXT
LONGEVITY-NEXT: Valutazione Non Invasiva Dei Determinanti Precoci Della Salute Cardiometabolica, Funzionale e Comportamentale in Bambini e Adolescenti
Sponsor study identifier
observational
2,000
1 country
1
Study Start
October 1, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
October 1, 2036
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
October 1, 2036
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
LONGEVITY-NEXT is a single-center, non-profit observational study designed to assess early non-invasive determinants of cardiometabolic, functional, behavioral, and environmental health in children and adolescents aged 6 to 17 years from the general population. Participants will undergo a standardized 15-20-minute non-invasive assessment including anthropometric measurements, blood pressure and heart rate, handgrip strength, dietary habits and adherence to the Mediterranean diet, physical activity, recreational screen time, sleep duration, tobacco smoke exposure, early-life factors, chronic health conditions, and family cardiometabolic history. The primary outcome is the distribution of the number of unfavorable cardiometabolic, behavioral, and environmental health domains per participant. The study involves no experimental treatment, drug, investigational medical device, invasive procedure, or modification of usual care. Optional repeated assessments may occur opportunistically during the study while participants remain between 6 and 17 years of age.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
October 1, 2036
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
September 3, 2026
Actual (reported)October 1, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
October 6, 2026
Actual (reported)October 1, 2036
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
October 1, 2036
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Number of Unfavorable Cardiometabolic, Behavioral, and Environmental Health Domains per Participant
For each participant, a count will be calculated across seven protocol-defined domains: weight status, blood pressure, adherence to the Mediterranean diet, physical activity, recreational screen time, sleep duration, and tobacco smoke exposure. Each domain classified as unfavorable contributes one point. The total count ranges from 0 to 7, with higher values indicating a greater number of unfavorable domains.
Baseline
Body Weight
Baseline
Waist Circumference
Baseline
Children and adolescents aged 6 to 17 years from the general population who voluntarily participate in LONGEVITY-NEXT and undergo the non-invasive multidimensional assessment specified in the study protocol.
Children and adolescents aged 6 to 17 years from the general population who voluntarily participate in LONGEVITY-NEXT and meet the protocol-defined eligibility criteria. Participants may be enrolled at Fondazione Policlinico Universitario Agostino Gemelli IRCCS or during health-promotion, community, school, or other territorial initiatives organized, authorized, or coordinated by the Sponsor. The presence of chronic conditions or functional limitations does not in itself preclude participation, provided that study participation is considered appropriate.
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Rome, Lazio, 00168, Italy
Francesco Landi, MD, PhD
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Federica Mammarella, MD, PhD
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
First Submitted
September 3, 2026
First Posted
October 6, 2026
Study Start
October 1, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
October 1, 2036
EstimatedEffect of Watermelon on Cardiometabolic Health
Calf Circumference
Baseline
Systolic Blood Pressure
Baseline
Right-Hand Handgrip Strength
Baseline
Contact the study team to confirm eligibility.
Planned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
October 1, 2036
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
October 6, 2026
Record last verified: 2026-09
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Source: ClinicalTrials.gov.
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