Trials Sponsors Conditions Drugs Pricing

Conditions

Cardiometabolic Health Indicators Whole-body Antioxidant Capacity

Outcome Measures

Primary Outcomes (3)

Postprandial blood pressure
To determine the acute and chronic effects of WMJ consumption on cardiometabolic health, specifically focusing on postprandial blood pressure. Previous studies showed that watermelon extract improved blood pressure management in subjects with prehypertension and hypertension and reduced arterial stiffness in postmenopausal women. Postprandial blood pressure response is recently identified to be the most sensitive postprandial clinical feature in predicting subclinical atherosclerosis. However, no study has evaluated the effect of watermelon on postprandial blood pressure. Blood pressure will be measured in mm/Hg.
Baseline and Week 4
Postprandial heart rate
Will be measured in beats per minute.
Baseline and 4 weeks.
Postprandial pulse wave velocity
Will be measured in meters/second.
Baseline and 4 weeks.

Secondary Outcomes (6)

Postprandial nitric oxide (NO)
Baseline and 4 weeks.
Postprandial glucose
Baseline and 4 weeks.
Postprandial blood lipids/lipoproteins (LDL cholesterol, HDL cholesterol, total cholesterol, triglycerides).
Baseline and 4 weeks.
Postprandial insulin
Baseline and 4 weeks.
Postprandial C-peptide
Baseline and 4 weeks.
+1 more secondary outcomes

Other Outcomes (2)

Minimal Erythema Dose (MED)
Baseline and week 4.
Blood and urinary malondialdehyde (MDA) concentrations
Baseline and 4 weeks.

Study Arms (2)

Watermelon Juice + liquid meal test at baseline

EXPERIMENTAL

Acute (postprandial) as well as chronic (4 weeks) effects of WMJ consumption will be evaluated. To evaluate acute effects participants will consume a liquid meal test together with WMJ at the beginning of the intervention phase. In addition, the same liquid meal test will be consumed with only WMJ at the end of the intervention phase to assess whether drinking the juice for 4 weeks prior had any effects on postprandial responses.

Other: Watermelon Juice + liquid meal test at baseline

Sweetened placebo beverage + liquid meal test at baseline

PLACEBO COMPARATOR

Participants will consume placebo beverage + liquid meal test at baseline. They will then consume watermelon juice daily for 4 weeks. Watermelon juice + liquid meal test will be consumed at endpoint.

Other: Sweetened placebo beverage +liquid meal test at baseline

Interventions

Watermelon Juice + liquid meal test at baselineOther

WMJ will be purchased from a commercially available brand. The liquid meal test will be in the form of the Boost nutritional drink (8 fl.oz., vanilla flavor), which is commercially available.

Watermelon Juice + liquid meal test at baseline

Sweetened placebo beverage +liquid meal test at baselineOther

The placebo beverage made of water and sugar will match the sugar content provided in 355 ml of WMJ (approximately 10-20 g). The liquid meal test will be in the form of the Boost nutritional drink (8 fl.oz., vanilla flavor), which is commercially available.

Eligibility Criteria

Sexfemale

Healthy VolunteersYes

Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

Female
Generally healthy

Sponsors & Collaborators

National Watermelon Promotion Board
Othercollaborator
University of California, Los Angeles
Otherlead

Study Sites (1)

UCLA Center for Human Nutrition

Los Angeles, California, 90095, United States

RECRUITING

Tatiana Diacova, PhD, MS, RDCONTACT310-206-8292 tdiacova@mednet.ucla.edu

Zhaoping Li, MD, PhDPRINCIPAL INVESTIGATOR

Study Officials

Zhaoping Li, MD, PhD
University of California, Los Angeles
PRINCIPAL INVESTIGATOR

Central Study Contacts

Tatiana Diacova, PhD, MS, RDN

CONTACT

3102068292 tdiacova@mednet.ucla.edu

Study Design

Study Type: interventional
Phase: not applicable
Allocation: RANDOMIZED
Masking: TRIPLE
Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose: PREVENTION
Intervention Model: CROSSOVER
Sponsor Type: OTHER
Responsible Party: PRINCIPAL INVESTIGATOR
PI Title: Principal Investigator

Study Record Dates

First Submitted

May 28, 2025

First Posted

June 5, 2025

Study Start

April 1, 2026

Actual (reported)

Primary Completion

September 1, 2027

Estimated

Effect of Watermelon on Cardiometabolic Health

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Outcome Measures

Primary Outcomes (3)

Secondary Outcomes (6)

Other Outcomes (2)

Study Arms (2)

Watermelon Juice + liquid meal test at baseline

Sweetened placebo beverage + liquid meal test at baseline

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Study Officials

Central Study Contacts

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Outcome Measures

Primary Outcomes (3)

Secondary Outcomes (6)

Other Outcomes (2)

Study Arms (2)

Watermelon Juice + liquid meal test at baseline

Sweetened placebo beverage + liquid meal test at baseline

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Study Officials

Central Study Contacts

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations