Sutureless Versus Conventional Suturing in Oral Surgery

NCT07856524 | Completed

• 1 other identifier: H-13-S-161/118
• Study Type: interventional
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

This randomized clinical study compares sutureless wound closure using n-butyl-2-cyanoacrylate tissue adhesive with conventional silk suturing following minor oral surgical procedures. The study evaluates wound healing as the primary outcome, along with postoperative pain, time to hemostasis, closure time, intraoperative blood loss, and postoperative complications. Eighty patients were randomly allocated in a 1:1 ratio to either sutureless closure or conventional suturing and were followed for 14 days after surgery.

Conditions

Wound Healing; Wound Healing Complication; Postoperative Pain; Oral and Maxillofacial Surgery Complications

Keywords

Oral Surgery; Postoperative pain; Silk sutures; Wound healing

Outcome Measures

Primary Outcomes (1)

• Wound Healing Score

  Wound healing assessed using the Landry, Turnbull, and Howley Healing Index, with scores ranging from 1 (very poor healing) to 5 (excellent healing).

  Postoperative Days 1, 3, 7, and 14

Study Arms (2)

Sutureless Closure

EXPERIMENTAL

Participants underwent sutureless wound closure using n-butyl-2-cyanoacrylate tissue adhesive (Histoacryl®) following minor oral surgical procedures. The wound margins were manually approximated, and a thin layer of tissue adhesive was applied along the approximated margins.

Procedure: Sutureless Wound Closure Using n-Butyl-2-Cyanoacrylate

Conventional Suturing

ACTIVE COMPARATOR

Participants underwent conventional wound closure using 3-0 black braided silk sutures placed in an interrupted pattern following minor oral surgical procedures. Sutures were removed on postoperative Day 7.

Procedure: Conventional Suturing

Interventions

Sutureless Wound Closure Using n-Butyl-2-Cyanoacrylate PROCEDURE

The study protocol describes the intervention as n-butyl-2-cyanoacrylate tissue adhesive (Histoacryl) used for sutureless wound closure.

Also known as: n-Butyl-2-Cyanoacrylate, Histoacryl®, Cyanoacrylate Tissue Adhesive

Sutureless Closure

Conventional Suturing PROCEDURE

The study uses interrupted 3-0 black braided silk sutures, which are removed on postoperative day 7.

Also known as: 3-0 Black Braided Silk Sutures

Conventional Suturing

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Patients aged 18 to 45 years.
• Classified as ASA physical status I or II.
• Indicated for minor oral surgical procedures, such as impacted mandibular third molar removal, alveoloplasty, or periapical surgery.
• Presence of healthy surrounding soft tissues at the surgical site.
• Willingness to participate and provide written informed consent.
• Ability to comply with postoperative follow-up visits.

You may not qualify if:

• Systemic diseases known to impair wound healing, including uncontrolled diabetes mellitus, immunocompromised states, autoimmune disorders, and chronic renal or hepatic disease.
• Bleeding disorders or use of anticoagulant/antiplatelet therapy.
• Chronic corticosteroid or immunosuppressive therapy.
• Active local infection at the surgical site.
• History of smoking or smokeless tobacco use within the past 6 months.
• Pregnant or lactating women.
• Known hypersensitivity to cyanoacrylate or suture materials.
• Poor oral hygiene, defined clinically by visible plaque accumulation and gingival inflammation.
• Patients requiring bone grafting, membrane placement, or complex flap designs.

Sponsors & Collaborators

• Jouf University: lead

Study Sites (1)

King Abdulaziz Specialist Hospital

Sakakah, Al Jawf Region, 72345, Saudi Arabia

Location

MeSH Terms

Conditions

Pain, Postoperative

Interventions

Enbucrilate

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Cyanoacrylates; Acrylates; Acids, Acyclic; Carboxylic Acids; Organic Chemicals; Nitriles; Polymers; Macromolecular Substances; Biomedical and Dental Materials; Tissue Adhesives; Manufactured Materials; Technology, Industry, and Agriculture

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr.

Study Record Dates

• First Submitted: September 28, 2026
• First Posted: October 2, 2026
• Study Start: February 1, 2026
• Primary Completion: May 28, 2026
• Study Completion: May 31, 2026
• Last Updated: October 2, 2026

Record last verified: 2026-09

Data Sharing

• IPD Sharing: Will not share

Locations

SA (1)