Comparison of Wound Healing Duration Between Vacuum-Assisted Closure (VAC) and Conventional Dressings

NCT07832162 | Not Yet Recruiting

• 1 other identifier: NO.F.2-81/2026-GENL/279/JPMC
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

This randomized controlled trial will compare vacuum-assisted closure (VAC) therapy with conventional wound dressings for the treatment of open contaminated and dirty wounds. The study will be conducted in the Department of General Surgery, Jinnah Postgraduate Medical Centre (JPMC), Karachi. Eligible patients aged 15 to 60 years with open contaminated or dirty wounds measuring 5-10 cm and classified as American Society of Anesthesiologists (ASA) grade I or II will be randomly allocated to either VAC therapy or conventional dressings. The primary outcome will be mean duration of wound healing, measured in days from initiation of the assigned treatment until complete wound healing according to predefined clinical criteria. The study will compare the duration of wound healing between the two treatment groups.

Conditions

Wound Healing

Keywords

VAC THERAPY; NEGATIVE PRESSURE WOUND THERAPY; CONVENTIONAL WOUND DRESSING; WOUND HEALING; SURGICAL WOUNDS; WOUND CARE; Vacuum-Assisted Closure

Outcome Measures

Primary Outcomes (1)

• Duration of Wound Healing

  Duration of wound healing, measured in days from initiation of the assigned treatment until complete wound healing according to the predefined clinical criteria. The mean duration in days will be compared between the VAC therapy and conventional dressing groups.

  From initiation of treatment until complete wound healing, up to 2 weeks.

Secondary Outcomes (3)

• Wound Infection

  From initiation of treatment until completion of the 2-week follow-up period.

• Length of Hospital Stay

  During the index hospital admission.

• Need for Additional Surgical Intervention

  From initiation of treatment until completion of the 2-week follow-up period.

Study Arms (2)

VAC Therapy

EXPERIMENTAL

Participants will receive vacuum-assisted closure (VAC) therapy for wound management.

Device: Vacuum-Assisted Closure (VAC) Therapy Description:

Conventional Dressing

ACTIVE COMPARATOR

Participants will receive conventional saline-soaked wound dressings.

Other: Conventional Wound Dressing

Interventions

Vacuum-Assisted Closure (VAC) Therapy Description: DEVICE

The wound will be covered with polyurethane foam and a multi-hole drain will be placed over it. The dressing will be sealed with an airtight dressing and connected to a negative-pressure system providing intermittent negative pressure of 125 mmHg, with 45 minutes ON and 15 minutes OFF cycles. VAC dressing changes will be performed every 48-72 hours.

VAC Therapy

Conventional Wound Dressing OTHER

Saline-soaked dressing will be placed over the wound and bandage applied, with dressing changes every 24 hours

Conventional Dressing

Eligibility Criteria

• Age: 15 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Patients having open contaminated and dirty wounds of size 5 - 10cm as per operational definition.
• Patients between ages 15 to 60 years.
• Both gender
• ASA grade I \& II
• Willing to provide written informed consent.

You may not qualify if:

• Patients with wounds having dry eschar, malignancy in wound, untreated osteomyelitis, exposed blood vessels and organs, long term anticoagulant therapy, bleeding disorders and fistula to organ / body cavities. Dermatological disorders like acute dermatitis, fungal infections of perianal region.
• All the patients presented with exposed bone, tendons or nerve will be excluded from study
• Pregnant women.
• Patients on medications, such as corticosteroids, immunosuppressive agents or chemotherapy. All above will be assessed on history and documented medical history.

Sponsors & Collaborators

• Jinnah Postgraduate Medical Centre: lead

Study Sites (1)

Jinnah Postgraduate Medical Centre

Karachi, Sindh, 74600, Pakistan

Location

Related Publications (2)

• Jamali MA, Memon SA, Sameena N, Tahmida A. Vacuum assisted closure versus conventional dressings in treatment of open untidy wounds. Esculapio. 2016;12(3):139-144.

  RESULT

• Cheema SA, Hafsa N, Shumaila RD, Urwa TA. Comparison of vacuum assisted closure technique versus conventional dressing for management of wounds in term of duration of wound healing. Ann Pak Med Coll. 2020;14(1):1-4.

  RESULT

MeSH Terms

Conditions

Surgical Wound

Interventions

Negative-Pressure Wound Therapy

Condition Hierarchy (Ancestors)

Wounds and Injuries

Intervention Hierarchy (Ancestors)

Drainage; Therapeutics; Surgical Procedures, Operative; Wound Closure Techniques

Central Study Contacts

Dr Aourangzaib Dr Aourangzaib, MBBS, FCPS

CONTACT

03347476661; zaibb9032@gmail.com

Dr Irfan Dr Irfan, mbbs

CONTACT

03042635107; irfankhoso103@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Asisstant professor

Model Details: Participants will be randomly allocated by lottery method to one of two parallel treatment groups. Group A will receive vacuum-assisted closure (VAC) therapy, while Group B will receive conventional wound dressings. The duration of wound healing will be compared between the two groups.

Study Record Dates

• First Submitted: September 11, 2026
• First Posted: September 21, 2026
• Study Start: September 20, 2026
• Primary Completion (Estimated): December 9, 2026
• Study Completion (Estimated): December 9, 2026
• Last Updated: September 21, 2026

Record last verified: 2026-09

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)