Socket Preservation After Surgical Extraction of Impacted Lower Third Molar

NCT06716736 | Completed DMC

• 1 other identifier: A08061222
• Study Type: interventional
• Target: 45
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study will be to evaluate socket preservation using autogenous particulate dentin in combination with liquid platelet-rich fibrin versus bone allografts and collagen cone after surgical extraction of the horizontally impacted lower third molar

Conditions

Socket Preservation

Keywords

socket preservation; dentine graft

Outcome Measures

Primary Outcomes (1)

• bone resorption distal to second molar

  by measuring bone level immediate and 3 months after extraction on CBCT

  3 months after extraction

Secondary Outcomes (3)

• bone density

  3 months after extraction

• edema

  4 days after extraction

• pain after surgical extraction

  4 days after extraction

Study Arms (3)

socket preservation with dentine graft mixed with liquid platelet rich fibrin (sticky tooth)

ACTIVE COMPARATOR

socket preservation with dentine graft mixed with liquid platelet rich fibrin (sticky tooth) after surgical extraction of horizontally impacted lower wisdom

Biological: socket preservation using dentine graft mixed with i-PRF

socket preservation with bone allograft

ACTIVE COMPARATOR

socket preservation with bone allograft after surgical extraction of horizontally impacted lower wisdom

Biological: socket preservation using bone allograft

socket preservation with collagen cone

ACTIVE COMPARATOR

socket preservation with collagen cone after surgical extraction of horizontally impacted lower wisdom

Biological: socket preservation using collagen cone

Interventions

socket preservation using dentine graft mixed with i-PRF BIOLOGICAL

surgical extraction of horizontally impacted third molar , placement of dentin graft mixed with i-PRF inside the socket , suturing

socket preservation with dentine graft mixed with liquid platelet rich fibrin (sticky tooth)

socket preservation using bone allograft BIOLOGICAL

surgical extraction of horizontally impacted third molar , placement of bone allograft inside the socket , suturing

socket preservation with bone allograft

socket preservation using collagen cone BIOLOGICAL

surgical extraction of horizontally impacted third molar , placement of collagen cone inside the socket , suturing

socket preservation with collagen cone

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Fresh extracted socket of horizontally impacted mandibular third molar
• Co-operative patients willing to complete the follow-up periods.
• Patients age from 18-35 years.
• Good oral hygiene.

You may not qualify if:

• Any pathological condition at the site of surgery.
• Patients with systemic diseases that contra-indicate the surgical procedure such as uncontrolled diabetes mellitus, bleeding disorders, serious osseous disorders and mental disorders.
• Smokers .
• Pregnancy.

Sponsors & Collaborators

• Wael Mohamed: lead

Study Sites (1)

Mansoura University

Al Mansurah, Eldakahlia, 35511, Egypt

Location

MeSH Terms

Interventions

proliferation regulatory factors, human urine

Study Officials

• Wael M Ahmed, PHD

  mansoura uniersity

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Professor of Oral and Maxillofacial Surgery

Study Record Dates

• First Submitted: November 29, 2024
• First Posted: December 4, 2024
• Study Start: December 1, 2022
• Primary Completion: December 15, 2023
• Study Completion: April 1, 2024
• Last Updated: December 4, 2024

Record last verified: 2024-11

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)