Alveolar Ridge Preservation Using Acemannan Aloe Vera Versus Natural Socket Healing

NCT07736053 | Completed DMC

• 1 other identifier: 14924
• Study Type: interventional
• Target: 26
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to evaluate the effectiveness of acemannan aloe vera powder extract in preserving the alveolar ridge following tooth extraction in healthy adult patients. It will also assess the healing process by radiographic and histomorphometric analyses. The main questions it aims to answer are: Does acemannan aloe vera powder extract improve alveolar ridge preservation compared with natural socket healing? Does the use of acemannan aloe vera powder extract enhance bone quality and new bone formation as assessed by radiographic and histomorphometric outcomes? Researchers will compare sockets treated with acemannan aloe vera powder extract to sockets allowed to heal naturally to determine whether the intervention results in improved dimensional preservation of the alveolar ridge and enhanced bone regeneration. Participants will: Undergo tooth extraction according to the study protocol. Be randomly assigned to receive either acemannan aloe vera powder extract for alveolar ridge preservation or natural socket healing without grafting. Attend scheduled follow-up visits for clinical and radiographic evaluations. Undergo radiographic assessment using cone-beam computed tomography (CBCT) to evaluate changes in alveolar ridge dimensions. Provide a bone biopsy at the time of implant placement for histomorphometric analysis of new bone formation and tissue composition.

Conditions

Socket Preservation

Keywords

socket prservation; Ridge preservation; Acemannan aloe vera; normal socket healing; Tooth extraction; delayed dental implant

Outcome Measures

Primary Outcomes (1)

• Change in radiographic horizontal ridge width at 4 mm below the most coronal aspect of the crest

  The immediate postoperative scans served as the baseline and were evaluated after 6 months to assess horizontal ridge width. Employing the same software, standardized measurements were obtained at both time points using consistent anatomical landmarks. On each baseline and after 6 months images, the apical point of the extraction socket was identified, and a vertical line was drawn through the socket's midpoint. A horizontal reference line perpendicular to the vertical axis was then established at the apical point. Horizontal ridge width was measured at 4 mm below the crest, yielding the parameters HW-4

  6 months postoperatively

Secondary Outcomes (3)

• Horizontal ridge width was measured at 2 mm and 6 mm below the crest

  6 months postoperatively

• Vertical ridge height

  6-months post

• Percentage of new vital bone formation

  6 months post

Study Arms (2)

Socket Preservation with Acemannan Aloe Vera Extract Powder

EXPERIMENTAL

After atraumatic tooth extraction and socket debridement, the Aloe vera mixture was then prepared by combining a 500 mg of Aloe vera powder , equivalent to approximately ¼ teaspoon, with 2 ml of sterile saline (Nimma et al., 2017). The mixture was immediately applied into the extraction socket and gently condensed using a bone graft condenser. A collagen plug was carefully placed above the Aloe vera mixture in the socket, ensuring close contact with all socket walls. Finally, the site was closed and stabilized using Vicryl 5-0 resorbable sutures to secure the collagen plug and support proper healing during the early postoperative phase

Biological: Aloe vera extract; Other: Normal Socket Healing

Control Group (Normal Socket Healing)

ACTIVE COMPARATOR

Following extraction, the sockets were carefully debrided to remove any debris and blood clots. The sockets were then left to heal naturally without the application of any adjunctive biomaterials.

Biological: Aloe vera extract; Other: Normal Socket Healing

Interventions

Aloe vera extract BIOLOGICAL

After atraumatic tooth extraction and socket debridement, the Aloe vera mixture was then prepared by combining a 500 mg of Aloe vera powder , equivalent to approximately ¼ teaspoon, with 2 ml of sterile saline (Nimma et al., 2017). The mixture was immediately applied into the extraction socket and gently condensed using a bone graft condenser. A collagen plug was carefully placed above the Aloe vera mixture in the socket, ensuring close contact with all socket walls. Finally, the site was closed and stabilized using Vicryl 5-0 resorbable sutures to secure the collagen plug and support proper healing during the early postoperative phase .

Control Group (Normal Socket Healing); Socket Preservation with Acemannan Aloe Vera Extract Powder

Normal Socket Healing OTHER

Control Group: Normal Socket Healing * Tooth Extraction: Standard tooth extraction procedures will be followed, ensuring minimal trauma to the surrounding bone and soft tissues. * Socket Cleaning: The extraction socket will be thoroughly cleaned and debrided to remove any debris and blood clots. * Natural Healing: The socket will be allowed to heal naturally without any additional intervention. Standard post-extraction care will be provided.

Control Group (Normal Socket Healing); Socket Preservation with Acemannan Aloe Vera Extract Powder

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Non-restorable tooth in maxillary or mandibular anterior esthetic region.
• Intact or minimally affected buccal plate of bone.
• Patients at least 18 years or older.
• Motivated patients, agree to sign the written informed consent and complete the follow-up period.

You may not qualify if:

• Infection at the extraction site.
• Smokers more than 10 cigarettes per day .
• Patients undergoing or having a history of radiotherapy, chemotherapy, or bisphosphonate therapy .
• Systemic conditions that may compromise healing or bone metabolism (e.g., uncontrolled diabetes, hyperthyroidism) .
• Patients on medication that may interfere with healing (Corticosteroids, Bisphosphonate, Chemo/radio therapy)
• Systemic diseases or medications that affect blood clotting
• Pregnant females or those planning to get pregnant during the study period (American Dental Association, 2011).

Sponsors & Collaborators

• Cairo University: lead

Study Sites (1)

Egypt Faculty of Dentistry Cairo University

Cairo, Egypt, 12613, Egypt

Location

MeSH Terms

Interventions

aloe vera gel extract hydrogel dressing

Study Officials

• Nouf Saeed Alamoudi, Bachelor

  Cairo University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator Nouf Alamoudi Master Degree student, Dental Imlantology department, Faculty of Dentistry, Cairo University

Study Record Dates

• First Submitted: July 20, 2026
• First Posted: July 30, 2026
• Study Start: October 1, 2024
• Primary Completion: July 1, 2025
• Study Completion: December 12, 2025
• Last Updated: July 30, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)