Renal Resistive Index as a Predictor of Acute Renal Impairment in High-risk Patients

NCT06386796 | Recruiting

• 1 other identifier: Asw.U./867/11/23
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

To study the ability of RRI, measured by bedside Doppler ultrasound, in detecting acute kidney injury in high-risk patients admitted to surgical intensive care unit, Aswan university hospital, compared with renal biomarkers and conventional assessment using urine output and serum creatinine levels.

Conditions

Acute Kidney Injury; Critical Illness

Keywords

renal resisitive index; surgical ICU; Cystatin C

Outcome Measures

Primary Outcomes (2)

• Early detection of acute kidney injury.

  Renal artery resistive index will be measured daily.Cystatin C will be measured on admission, after 24 hours and 72 hours.

  Day 0,1,2,3,7

• Diagnosis of acute kidney injury.

  Renal artery resistive index will be measured daily.Cystatin C will be measured on admission, after 24 hours and 72 hours.

  Day 0,1,2,3,7

Secondary Outcomes (4)

• To grade the severity of AKI.

  day 0,1,2,3,7

• To predict clinical outcome (clinical improvement)

  Day 0,1,2,3,7,30

• To predict clinical outcome (necessity for renal replacement therapy)

  Day 0,1,2,3,7,30

• To predict clinical outcome (death)

  Day 0,1,2,3,7,30

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

patients who are admitted to SICU, Aswan university hospital, after polytrauma, pre-eclampsia, eclampsia and sepsis

You may qualify if:

• Patients with severe pre-eclampsia and eclampsia.
• Polytraumatized patients.
• Patients admitted to ICU with sepsis.
• Both genders.
• Patients above 18 years.

You may not qualify if:

• patients known to have CKD.
• patients with congenital renal anomalies.
• patients with renal transplantation.

Sponsors & Collaborators

• Aswan University: lead

Study Sites (1)

Aswan University

Aswān, Aswan Governorate, 81528, Egypt

RECRUITING

Related Publications (4)

• Pan HC, Yang SY, Chiou TT, Shiao CC, Wu CH, Huang CT, Wang TJ, Chen JY, Liao HW, Chen SY, Huang TM, Yang YF, Lin HY, Chan MJ, Sun CY, Chen YT, Chen YC, Wu VC. Comparative accuracy of biomarkers for the prediction of hospital-acquired acute kidney injury: a systematic review and meta-analysis. Crit Care. 2022 Nov 12;26(1):349. doi: 10.1186/s13054-022-04223-6.

  PMID: 36371256 BACKGROUND

• Cruz EG, Broca Garcia BE, Sandoval DM, Gopar-Nieto R, Gonzalez Ruiz FJ, Gallardo LD, Ronco C, Madero M, Vasquez Jimenez E. Renal Resistive Index as a Predictor of Acute Kidney Injury and Mortality in COVID-19 Critically Ill Patients. Blood Purif. 2022;51(4):309-316. doi: 10.1159/000517469. Epub 2021 Jul 19.

  PMID: 34280921 BACKGROUND

• Provenzano M, Rivoli L, Garofalo C, Faga T, Pelagi E, Perticone M, Serra R, Michael A, Comi N, Andreucci M. Renal resistive index in chronic kidney disease patients: Possible determinants and risk profile. PLoS One. 2020 Apr 1;15(4):e0230020. doi: 10.1371/journal.pone.0230020. eCollection 2020.

  PMID: 32236125 BACKGROUND

• Fernando S, Polkinghorne KR. Cystatin C: not just a marker of kidney function. J Bras Nefrol. 2020 Mar;42(1):6-7. doi: 10.1590/2175-8239-JBN-2019-0240. Epub 2020 Apr 3. No abstract available.

  PMID: 32255469 BACKGROUND

MeSH Terms

Conditions

Acute Kidney Injury; Critical Illness

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Mohamed H Abolwafa, MSc

  Aswan University

  PRINCIPAL INVESTIGATOR

• Ahmed E Abd Elrahman, MD

  Sohag University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Soudy S Hammad, MD

CONTACT

201014761523; soudi.salah@aswu.edu.eg

Tarek S Hemaida, MD

CONTACT

01007363190; dr.tarek@aswu.edu.eg

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer of anesthesia and surgical intensive care

Study Record Dates

• First Submitted: April 4, 2024
• First Posted: April 26, 2024
• Study Start: April 1, 2024
• Primary Completion (Estimated): October 1, 2026
• Study Completion (Estimated): October 1, 2026
• Last Updated: March 10, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)