Pre-Exercise Whey and Pea Protein in Adolescents With Type 1 Diabetes

NCT07836673 | Not Yet Recruiting DMC

• 2 other identifiers: UJ-T1D-PRO-2026UJ IRB Approval Number
• Study Type: interventional
• Target: 30
• Locations: 0 countries
• Sites: N/A

Brief Summary

The goal of this clinical trial is to learn whether drinking whey protein or pea protein before exercise affects blood sugar levels and appetite in adolescents with type 1 diabetes. The study will also compare two different amounts of each type of protein. The main questions this study aims to answer are:

• Does drinking whey or pea protein before exercise affect blood sugar levels during and after moderate-intensity exercise?
• Does the amount of protein consumed before exercise affect blood sugar levels?
• Does whey or pea protein affect feelings of hunger, fullness, and satiety after exercise? Researchers will compare four conditions: a low and moderate amount of whey protein and a low and moderate amount of pea protein. Each participant will complete all four conditions on separate study visits, allowing researchers to compare the effects within the same person. Participants will:
• Drink a protein beverage 45 min before exercise.
• Complete 45 min moderate-intensity aerobic exercise under supervision.
• Wear a continuous glucose monitor to measure blood sugar levels during and after exercise.
• Report their feelings of hunger, fullness, and satiety at several times during the study.
• Follow the same general food, physical activity, and diabetes management instructions before each study visit. The study may help researchers understand whether the type and amount of protein consumed before exercise can help manage blood sugar levels and appetite around exercise in adolescents with type 1 diabetes.

Conditions

T1D; T1DM

Keywords

RCT

Outcome Measures

Primary Outcomes (1)

• Continuous blood glucose levels using CGM "FreeStyle Libre 2 sensor"

  3 hours

Secondary Outcomes (1)

• postprandial appetite using VAS

  3 hours

Study Arms (4)

low whey protein

EXPERIMENTAL

Participants will consume a whey protein beverage providing 0.25 g of protein per kg of body weight, 45 minutes before moderate-intensity aerobic exercise. They will then complete the standardized exercise session under supervision. Glucose levels and appetite will be monitored during and after exercise.

Dietary Supplement: low whey protein

moderate whey protein

EXPERIMENTAL

Participants will consume a whey protein beverage providing the moderate prespecified dose of protein per kg of body weight, 45 minutes before moderate-intensity aerobic exercise. They will then complete the standardized exercise session under supervision. Glucose levels and appetite will be monitored during and after exercise.

Dietary Supplement: moderate whey protein

low pea protein

EXPERIMENTAL

Dietary Supplement: low Pea protein

moderate pea protein

EXPERIMENTAL

Dietary Supplement: Moderate Pea protein

Interventions

moderate whey protein DIETARY_SUPPLEMENT

Participants will consume a whey protein beverage providing the moderate prespecified dose of protein per kg of body weight, 45 minutes before moderate-intensity aerobic exercise. They will then complete the standardized exercise session under supervision. Glucose levels and appetite will be monitored during and after exercise.

moderate whey protein

Moderate Pea protein DIETARY_SUPPLEMENT

Participants will consume a pea protein beverage providing the moderate prespecified dose of protein per kg of body weight, 45 minutes before moderate-intensity aerobic exercise. They will then complete the standardized exercise session under supervision. Glucose levels and appetite will be monitored during and after exercise.

moderate pea protein

low whey protein DIETARY_SUPPLEMENT

Participants will consume a whey protein beverage providing 0.25 g of protein per kg of body weight, 45 minutes before moderate-intensity aerobic exercise. They will then complete the standardized exercise session under supervision. Glucose levels and appetite will be monitored during and after exercise.

low whey protein

low Pea protein DIETARY_SUPPLEMENT

Participants will consume a pea protein beverage providing 0.25 g of protein per kg of body weight, 45 minutes before moderate-intensity aerobic exercise. They will then complete the standardized exercise session under supervision. Glucose levels and appetite will be monitored during and after exercise.

low pea protein

Eligibility Criteria

• Age: 12 Years - 18 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Male and female adolescents with T1D
• Age: 12-18 years
• T1D duration ≥ 1 year and HbA1c \<10%
• BMI-for Age- z-score between -2 and +2
• Able to complete 45 min moderate-intensity aerobic exercise
• Using CGM or willing / able to wear study CGM
• Using multiple daily injections

You may not qualify if:

• Medical comorbidities (celiac disease and thyroid disease),
• Diabetes complications or gastroparesis,
• milk protein allergy or eating disorders,
• severe hypo/ diabetic ketoacidosis in the past 3 months
• Age: \<12 or \> 18 years
• T1D duration \< 1 year or HbA1c ≥10%
• BMI -for Age- z-score \< -2 or \> +2
• Unable to exercise safely (physical limitations, intellectual disability, autism, mental health conditions)
• Not using/willing/able to use CGM
• Using once daily/mixed insulin regimens

Sponsors & Collaborators

• University of Jordan: lead

Central Study Contacts

Sondos Alobaidi

CONTACT

00962796329336; sondosalobaidi@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: SUPPORTIVE CARE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD Student, Department of Nutrition and Food Technology, School of Agriculture, The University of Jordan

Study Record Dates

• First Submitted: September 10, 2026
• First Posted: September 23, 2026
• Study Start: October 1, 2026
• Primary Completion (Estimated): February 1, 2027
• Study Completion (Estimated): March 1, 2027
• Last Updated: September 23, 2026

Record last verified: 2026-09

Data Sharing

• IPD Sharing: Will not share