Mechanical Power and Mortality in Mechanically Ventilated Adults

NCT07836153 | Not Yet Recruiting

• 1 other identifier: ZU-MP-MORTALITY-2026
• Study Type: observational
• Target: 116
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective observational cohort study aims to investigate the relationship between mechanical power during the first 72 hours of invasive mechanical ventilation and 28-day mortality in mechanically ventilated adult patients admitted to the Surgical Intensive Care Unit at Zagazig University Hospitals.

Conditions

Mechanical Ventilation Complication; Ventilator Induced Lung Injury; ARDS; ICU Mortality (Survival Rate)

Keywords

Mechanical ventilation; Driving Pressure; 28-Day Mortality; Critically Ill Patients

Outcome Measures

Primary Outcomes (1)

• 28-Day Mortality

  All-cause mortality within 28 days after initiation of invasive mechanical ventilation.

  At 28 days after initiation of invasive mechanical ventilation

Secondary Outcomes (3)

• Driving Pressure and Plateau Pressure

  At 24, 48, and 72 hours after initiation of invasive mechanical ventilation

• Ventilator-Free Days

  Through 28 days after initiation of invasive mechanical ventilation

• ICU Length of Stay

  From ICU admission until ICU discharge or death, through 28 days after initiation of invasive mechanical ventilation

Study Arms (1)

Mechanically Ventilated Adult Patients

Adult patients requiring invasive mechanical ventilation and admitted to the Surgical Intensive Care Unit at Zagazig University Hospitals.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients requiring invasive mechanical ventilation and admitted to the Surgical Intensive Care Unit at Zagazig University Hospitals.

You may qualify if:

• Age ≥18 years.
• Both sexes.
• Patients requiring invasive controlled mechanical ventilation in the ICU and expected to require mechanical ventilation for at least 72 hours.
• Enrollment within the first 8 hours after initiation of invasive mechanical ventilation.
• Acceptance and written informed consent from a first-degree relative.

You may not qualify if:

• Predominant spontaneous breathing or weaning modes during the first 48 hours.
• Severe hemodynamic instability precluding standardized measurements.
• Prolonged mechanical ventilation prior to ICU admission.
• Pregnancy.
• Chest trauma.

Sponsors & Collaborators

• Zagazig University: lead

Study Sites (1)

Surgical Intensive Care Unit, Zagazig University Hospitals

Zagazig, Sharqia Province, Egypt

Location

MeSH Terms

Conditions

Ventilator-Induced Lung Injury

Condition Hierarchy (Ancestors)

Lung Injury; Lung Diseases; Respiratory Tract Diseases

Study Officials

• Ghada M Abd Elrazik, Prof of anesthesia and Icu

  Zagazig University

  STUDY CHAIR

• Asmaa M Galal Eldin, Assistant prof anesthesia,Icu

  Zagazig University

  STUDY CHAIR

• Ahmed A Ibrahim, Lecturer of anesthesia, Icu

  Zagazig University

  STUDY CHAIR

Central Study Contacts

Tasneem Y Elshawadfy

CONTACT

201097684895; Tasneemelserafy206@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 9, 2026
• First Posted: September 23, 2026
• Study Start: September 10, 2026
• Primary Completion (Estimated): May 25, 2027
• Study Completion (Estimated): August 18, 2027
• Last Updated: September 23, 2026

Record last verified: 2026-09

Locations

EG (1)