A New Ultrasonographic Tool to Assess Pulmonary Strain in the ICU

NCT03405779 | Recruiting

• 1 other identifier: 17.277
• Study Type: observational
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

The primary objective of the study is to create a small dataset of regional pulmonary strain values in patients suffering from pulmonary diseases under mechanical ventilation in an intensive care setting. Hypothesis: The analysis of lung ultrasonographic sequences using speckle-tracking allows the determination of local pleural strain in 4 predetermined pulmonary areas in mechanically ventilated patients suffering from pulmonary diseases.

Conditions

Mechanical Ventilation Complication; Ventilator-Induced Lung Injury

Outcome Measures

Primary Outcomes (1)

• Average absolute lateral deformation

  Change in percentage from baseline expiratory value

  At the end of study on Day 1

Secondary Outcomes (6)

• Cumulated range of absolute lateral deformation

  At the end of study on Day 1

• Average absolute axial deformation

  At the end of study on Day 1

• Cumulated range of absolute axial deformation

  At the end of study on Day 1

• Average von mises

  At the end of study on Day 1

• Average absolute lateral shear

  At the end of study on Day 1

Interventions

Lung ultrasonography PROCEDURE

Mechanically ventilated patients suffering from pulmonary diseases will undergo a lung ultrasonography during their stay in the intensive care unit (ICU)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult Intensive care patients under mechanical ventilation suffering from a pulmonary disease.

You may qualify if:

• Adult intensive care patients under mechanical ventilation suffering from a pulmonary disease with a static lung compliance of less than 40 mL/cm H2O.

You may not qualify if:

• Obesity (Body Mass Index superior to 30 kg/m2)
• Previous thoracic procedure (chest tube, thoracotomy, thoracoscopy)
• Intra-abdominal pressure inferior to 15 mm Hg (if available)
• Previous participation to the study

Sponsors & Collaborators

• Centre hospitalier de l'Université de Montréal (CHUM): lead

Study Sites (1)

Centre Hospitalier de l'Université de Montréal (CHUM)

Montreal, Quebec, H2X 3E4, Canada

RECRUITING

MeSH Terms

Conditions

Ventilator-Induced Lung Injury

Condition Hierarchy (Ancestors)

Lung Injury; Lung Diseases; Respiratory Tract Diseases

Study Officials

• Martin Girard, MD,FRCPC

  Centre hospitalier de l'Université de Montréal (CHUM)

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Martin Girard, MD,FRCPC

CONTACT

514-890-8000; martin.girard@umontreal.ca

Julie Desroches, PhD

CONTACT

514-890-8000; julie.desroches.chum@ssss.gouv.qc.ca

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 15, 2018
• First Posted: January 23, 2018
• Study Start: March 12, 2018
• Primary Completion: January 1, 2026
• Study Completion: February 1, 2026
• Last Updated: September 18, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)