Early Neurological Outcome in Pediatric Encephalitis

NCT07830927 | Not Yet Recruiting

• 1 other identifier: Encephalitis-Outcome-Assiut-20
• Study Type: observational
• Target: 88
• Locations: 0 countries
• Sites: N/A

Brief Summary

This prospective cohort study aims to identify baseline clinical, laboratory, and radiological factors at admission that are associated with early neurological outcomes in children with encephalitis admitted to Assiut University Children Hospital.

Conditions

Encephalitis; Brain Diseases; Neurologic Manifestations

Keywords

Pediatric encephalitis; Assiut; Modified Rankin Scale; Neurological outcome

Outcome Measures

Primary Outcomes (1)

• Functional neurological outcome at discharge

  Score on the pediatric modified Rankin Scale at hospital discharge. The scale ranges from 0 (no symptoms) to 6 (death), with higher scores indicating worse functional outcome

  Up to 30 days

Secondary Outcomes (4)

• Duration of hospital stay

  Up to 30 days

• Need for intensive care unit admission

  Up to 30 days

• Need for nasogastric tube feeding at discharge

  Up to 30 days

• Nosocomial infections

  Up to 30 days

Study Arms (1)

Single cohort: Children with encephalitis

Children aged 1 month to 12 years with possible or probable encephalitis who will be assessed for early neurological outcome at hospital discharge using the pediatric modified Rankin Scale.

Eligibility Criteria

• Age: 1 Month - 12 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

Children aged 1 month to 12 years admitted to Assiut University Children Hospital with possible or probable encephalitis according to the International Encephalitis Consortium 2013 case definition.

You may qualify if:

• Age from 1 month to 12 years
• Possible or probable encephalitis according to the International Encephalitis Consortium 2013 case definition
• Written informed consent from parents or legal guardians

You may not qualify if:

• Pre-existing severe neurodisability pediatric modified Rankin Scale greater than or equal to 3 before the index illness
• Primary diagnosis of traumatic brain injury or cerebral malaria
• Known inborn error of metabolism or neurodegenerative disorder prior to the encephalitis episode
• Absence of documented neurologic outcome assessment

Sponsors & Collaborators

• Assiut University: lead

Related Publications (3)

• Granerod J, Ambrose HE, Davies NW, Clewley JP, Walsh AL, Morgan D, Cunningham R, Zuckerman M, Mutton KJ, Solomon T, Ward KN, Lunn MP, Irani SR, Vincent A, Brown DW, Crowcroft NS; UK Health Protection Agency (HPA) Aetiology of Encephalitis Study Group. Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study. Lancet Infect Dis. 2010 Dec;10(12):835-44. doi: 10.1016/S1473-3099(10)70222-X. Epub 2010 Oct 15.

  PMID: 20952256 BACKGROUND

• Venkatesan A, Tunkel AR, Bloch KC, Lauring AS, Sejvar J, Bitnun A, Stahl JP, Mailles A, Drebot M, Rupprecht CE, Yoder J, Cope JR, Wilson MR, Whitley RJ, Sullivan J, Granerod J, Jones C, Eastwood K, Ward KN, Durrheim DN, Solbrig MV, Guo-Dong L, Glaser CA; International Encephalitis Consortium. Case definitions, diagnostic algorithms, and priorities in encephalitis: consensus statement of the international encephalitis consortium. Clin Infect Dis. 2013 Oct;57(8):1114-28. doi: 10.1093/cid/cit458. Epub 2013 Jul 15.

  PMID: 23861361 BACKGROUND

• Pillai SC, Hacohen Y, Tantsis E, Prelog K, Merheb V, Kesson A, Barnes E, Gill D, Webster R, Menezes M, Ardern-Holmes S, Gupta S, Procopis P, Troedson C, Antony J, Ouvrier RA, Polfrit Y, Davies NW, Waters P, Lang B, Lim MJ, Brilot F, Vincent A, Dale RC. Infectious and autoantibody-associated encephalitis: clinical features and long-term outcome. Pediatrics. 2015 Apr;135(4):e974-84. doi: 10.1542/peds.2014-2702.

  PMID: 25802349 BACKGROUND

MeSH Terms

Conditions

Encephalitis; Brain Diseases; Neurologic Manifestations

Condition Hierarchy (Ancestors)

Central Nervous System Diseases; Nervous System Diseases; Neuroinflammatory Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Faisel A Ahmed, prof

  Pediatrics Department, Assiut University Hospitals

  STUDY CHAIR

Central Study Contacts

Rania A Hussein

CONTACT

01280633697; Rania.18313530@med.aun.edu.eg

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident Physician, Pediatrics department

Study Record Dates

• First Submitted: September 15, 2026
• First Posted: September 21, 2026
• Study Start: September 20, 2026
• Primary Completion (Estimated): September 25, 2027
• Study Completion (Estimated): February 25, 2028
• Last Updated: September 22, 2026

Record last verified: 2026-09