EURopean Study on Encephalitis in Intensive CAre
EURECA
1 other identifier
observational
596
6 countries
65
Brief Summary
Prospective observational multicenter study in European ICUs. All patients admitted to the ICU for probable or confirmed Acute encephalitis (2013 IDSA - Infectious Disease Society of America criteria) will be included. Factors associated with a poor prognosis will be identified by multivariate analysis using a logistic regression.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jun 2017
Typical duration for all trials
65 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 3, 2017
CompletedFirst Posted
Study publicly available on registry
May 9, 2017
CompletedStudy Start
First participant enrolled
June 1, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 6, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2020
CompletedApril 1, 2021
March 1, 2021
3.1 years
May 3, 2017
March 29, 2021
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Modified Rankin scale score
The modified Rankin Scale (mRS) is a commonly used scale for measuring the degree of disability or dependence in the daily activities of people who have suffered a stroke or other causes of neurological disability. It has become the most widely used clinical outcome measure for stroke clinical trials.
Day 90
Secondary Outcomes (5)
Mortality at Day 28
Day 28
Systematic complications
Day 90
Intracranial complications
Day 90
Intracranial pressure monitoring
Day 90
Neurosurgery
Day 90
Interventions
Not applicable, non-interventional study
Eligibility Criteria
1000 patients admitted to the ICU for AE (5 consecutive patients in each participating ICU, targeted number of ICUs in Europe : 200).
You may qualify if:
- Age ≥ 18 years
- non-opposition to participate in the study (or consent if applicable according to local legislation)
- Impaired consciousness (altered mentation, stupor, or personality changes) for a duration ≥ 24 h, without obvious explanation
- A score on the Glasgow Coma Scale \< or =13 at ICU admission
- A Cerebrospinal fluid pleocytosis \> = 5 cell / mm3
- At least 2 of the following :
- Fever (≥ 38.0 °C) within 72 hours before or after admission
- Generalized or partial seizures non-attributable to pre-existing epilepsy
- New onset focal neurological deficit
- Parenchymal abnormalities on MRI compatible with AE
- EEG alterations compatible with AE.
You may not qualify if:
- CSF or neuroimaging not available (s) or not performed.
- febrile encephalopathy associated with another diagnosis (sepsis, neurological disease with aspiration pneumonia ... )
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- ICUREsearchlead
Study Sites (65)
Medical University of Innsbruck
Innsbruck, Austria
Centre Hospitalier d'Angoulême
Angoulême, 16000, France
Centre Hospitalier Annecy Genevois
Annecy, 74370, France
Hôpital Victor Dupouy
Argenteuil, 95107, France
Hôpital Ambroise Paré
Boulogne-Billancourt, 92104, France
CHU Brest
Brest, 29200, France
Hôpital Pierre Wertheimer
Bron, 69677, France
Centre Hospitalier René Dubos
Cergy-Pontoise, 95303, France
CH de Charlesville-Mézières
Charleville-Mézières, 08011, France
Les Hôpitaux de Chartres
Chartres, 28018, France
Centre Hospitalier Châlons en Champagne
Châlons-en-Champagne, 51000, France
Centre Hospitalier Public du Cotentin
Cherbourg, 50100, France
Hôpital Antoine Béclère
Clamart, 92140, France
CHU Gabriel Montpied
Clermont-Ferrand, 63000, France
APHP Colombes - Louis Mourier
Colombes, 92701, France
Centre Hospitalier du Sud Francilien
Corbeil-Essonnes, 91160, France
Hôpitaux Universitaires Henri Mondor
Créteil, 94000, France
Centre hopsitalier de Dieppe
Dieppe, 76200, France
Centre hospitalier Sud Essone
Étampes, 91150, France
CHU Grenoble
Grenoble, 38043, France
Marne la Vallée - Meaux
Jossigny, 77600, France
CH Vendée
La Roche, 85925, France
CH du Mans
Le Mans, 72037, France
Hôpital R Salengro
Lille, 59000, France
Centre Hospitalier Lorient
Lorient, 56322, France
Hôpital Edouard Herriot
Lyon, 69437, France
Institut Paoli-Calmettes
Marseille, 13009, France
Hôpital de la Timone
Marseille, 13385, France
CHU Hôpital Nord
Marseille, 13915, France
CHR Metz-Thionville
Metz, 57085, France
CHU Lapeyronie
Montpellier, 34090, France
CHU de Nantes
Nantes, 44093, France
Hôpital de la Source
Orléans, 45100, France
Hôpital Saint Louis
Paris, 75010, France
Hôpital Cochin
Paris, 75014, France
Hôpital Européen Georges-Pompidou
Paris, 75015, France
Hôpital Bichat Claude Bernard
Paris, 75018, France
Hôpitaux universitaires Est Parisien, Tenon
Paris, 75020, France
Groupe Hospitalier Paris Saint-Joseph
Paris, 75104, France
Groupe hospitalier Pitié-Salpêtrière
Paris, 75651, France
Fondation Opthalmologique Adolphe de Rothschild
Paris, 75940, France
Centre Hospitalier de Pau
Pau, 64000, France
Centre Hospitalier Intercommunal de Poissy
Poissy, 78303, France
CHU Rennes
Rennes, 35033, France
CH Roanne
Roanne, France
Centre hospitalier de Saint-Denis, Hôpital DELAFONTAINE
Saint-Denis, 93200, France
CHU de Toulouse Purpan
Toulouse, 31300, France
Centre hospitalier de Tourcoing
Tourcoing, 59200, France
Hôpital André Mignot
Versailles, 78150, France
CH des 2 vallées, Site Longjumeau
Longjumeau, Île-de-France Region, 91160, France
Ims & Sum Hospital
Bhubaneswar, India
Sanjay Gandhi Post Graduate Institute of Medical Sciences
Lucknow, 226014, India
Institute Of Medical Sciences Banaras Hindu University
Lucknow, India
King George's medical university
Lucknow, India
Sri Ramachandra Institute of Higher Education and Research
Lucknow, India
Azienda USL Toscana Centro
Florence, Italy
San Gerardo Hospital
Monza, 20900, Italy
Università Cattolica del Sacro Cuore
Roma, 00168, Italy
Academic Medical Center
Amsterdam, 1105, Netherlands
Hospital Vall d'Hebron
Barcelona, 08035, Spain
Hospital de la Santa Creu
Barcelona, 08041, Spain
Germans Trias i Pujol
Barcelona, 08916, Spain
Hospital Universitario Puerta de Hierro Majadahonda
Madrid, 28222, Spain
Complexo Hospitalario Universitario de Ourense
Ourense, 32005, Spain
Hospital Universitari Arnau de Vilanova
Zaragoza, Spain
Related Publications (1)
Sonneville R, de Montmollin E, Contou D, Ferrer R, Gurjar M, Klouche K, Sarton B, Demeret S, Bailly P, da Silva D, Escudier E, Le Guennec L, Chabanne R, Argaud L, Ben Hadj Salem O, Thyrault M, Frerou A, Louis G, De Pascale G, Horn J, Helbok R, Geri G, Bruneel F, Martin-Loeches I, Taccone FS, De Waele JJ, Ruckly S, Staiquly Q, Citerio G, Timsit JF; EURECA Investigator Study Group. Clinical features, etiologies, and outcomes in adult patients with meningoencephalitis requiring intensive care (EURECA): an international prospective multicenter cohort study. Intensive Care Med. 2023 May;49(5):517-529. doi: 10.1007/s00134-023-07032-9. Epub 2023 Apr 6.
PMID: 37022378DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Jean François Timsit
ICUREsearch
- PRINCIPAL INVESTIGATOR
Romain Sonneville
Hôpital Bichat, APHP
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Target Duration
- 3 Months
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 3, 2017
First Posted
May 9, 2017
Study Start
June 1, 2017
Primary Completion
July 6, 2020
Study Completion
December 31, 2020
Last Updated
April 1, 2021
Record last verified: 2021-03
Data Sharing
- IPD Sharing
- Will not share