EEG Abnormalities as Predictor of Outcome in Pediatric Encephalopathy

NCT07825675 | Not Yet Recruiting

• 1 other identifier: EEG-Encephalopathy-Assiut-2026
• Study Type: observational
• Target: 147
• Locations: 0 countries
• Sites: N/A

Brief Summary

This prospective cohort study aims to evaluate the prognostic value of electroencephalographic (EEG) abnormalities in predicting poor clinical outcomes among children with encephalopathy admitted to Assiut University Children Hospital.

Conditions

Encephalopathy; Brain Diseases

Keywords

EEG; Pediatric encephalopathy; Prognosis; PCPC; Neurological outcome; Assiut

Outcome Measures

Primary Outcomes (1)

• Poor neurological outcome at hospital discharge

  Proportion of children with poor neurological outcome defined as Pediatric Cerebral Performance Category (PCPC) score ≥3 at hospital discharge.

  at 30 days

Secondary Outcomes (4)

• Frequency of EEG abnormalities

  Within the first 48 hours of admission

• Predictive performance of EEG abnormalities for poor outcome

  at 30 days

• Mortality

  at 30 days

• Duration of PICU stay

  at 30 days

Study Arms (1)

Single cohort: Children with encephalopathy

Children aged 1 month to 18 years with clinical diagnosis of encephalopathy who will undergo EEG within the first 48 hours of admission and will be assessed for neurological outcome at hospital discharge using the PCPC scale.

Eligibility Criteria

• Age: 1 Month - 18 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Children aged 1 month to 18 years admitted with encephalopathy to the Pediatric Intensive Care Unit, Pediatric Neurology Unit, or Emergency Unit of Assiut University Children Hospital.

You may qualify if:

• Age from 1 month to 18 years
• Clinical diagnosis of encephalopathy with altered level of consciousness
• EEG performed within the first 48 hours of admission
• Written informed consent from parents or legal guardians

You may not qualify if:

• Neonatal encephalopathy
• Children with severe pre-existing neurological disability
• Known epileptic patients
• Incomplete clinical or EEG data

Sponsors & Collaborators

• Assiut University: lead

Related Publications (4)

• Abdelrazic MI, Hemeda MS, Abd-Elaziz MA, Mahmoud AR, Abuelela IS. Prevalence and patterns of abnormal metabolic screening in pediatric acute encephalopathy: a PICU study from Egypt. Eur J Pediatr. 2026 Apr 23;185(5):292. doi: 10.1007/s00431-026-06939-x.

  PMID: 42024203 BACKGROUND

• Dempsey LA. Building immune barriers. Nat Immunol. 2025 Apr;26(4):528. doi: 10.1038/s41590-025-02127-5. No abstract available.

  PMID: 40164807 BACKGROUND

• Imataka G, Kuwashima S, Yoshihara S. A Comprehensive Review of Pediatric Acute Encephalopathy. J Clin Med. 2022 Oct 7;11(19):5921. doi: 10.3390/jcm11195921.

  PMID: 36233788 BACKGROUND

• Camargo LL, Rios FJ, Montezano AC, Touyz RM. Reactive oxygen species in hypertension. Nat Rev Cardiol. 2025 Jan;22(1):20-37. doi: 10.1038/s41569-024-01062-6. Epub 2024 Jul 24.

  PMID: 39048744 BACKGROUND

MeSH Terms

Conditions

Brain Diseases

Condition Hierarchy (Ancestors)

Central Nervous System Diseases; Nervous System Diseases

Study Officials

• Gamal A Asker, prof

  Pediatrics Department, Assiut University Hospitals

  STUDY CHAIR

Central Study Contacts

Esraa M Tamer, Resident

CONTACT

+20 11 58780125; Esraa.17289969@med.aun.edu.eg

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 30 Days
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident Physician

Study Record Dates

• First Submitted: September 9, 2026
• First Posted: September 17, 2026
• Study Start: September 10, 2026
• Primary Completion (Estimated): September 10, 2027
• Study Completion (Estimated): March 10, 2028
• Last Updated: September 17, 2026

Record last verified: 2026-09