Effects of a Multi-Targeted Oral Supplement on Skin, Hair, Sleep, Energy, Cognition, Libido and Epigenetic Biological Clock Age

NCT07827651 | Active Not Recruiting DMC

• 2 other identifiers: IDF_AdvancedID_001217430
• Study Type: interventional
• Target: 64
• Locations: 1 country
• Sites: 1

Brief Summary

This study evaluated the effects of a daily oral supplement regimen (Advanced ID Brain, Heart and Eye Omega Gel Capsules taken with Advanced ID Longevity and Collagen Complex Powder) on measures of skin condition, hair, sleep, energy, cognition and sexual wellbeing in healthy adults aged 35 to 65 years. Participants were randomised in a 2:1 ratio to receive either the active supplement regimen or a matched placebo regimen once daily with food for 12 weeks. Instrumental skin measurements, trained-assessor visual grading and participant questionnaires were performed at baseline (Day 0), Day 28 and Day 84. Hair imaging and cognitive testing were performed at baseline and Day 84. Whole blood samples were collected at baseline and Day 84 for exploratory epigenetic DNA biological clock age analysis, reported separately. The study was single-centre, sponsored by IDI Skincare Limited and conducted by Eurofins Product Testing Services Ltd (trading as Eurofins Alba) in Edinburgh, United Kingdom.

Conditions

Longevity; Healthspan Improvement; Cognitive Processing Speed; Hair Aging; Recovery; Sleep; Biological Ageing; BIOLOGICAL CLOCKS; Skin Ageing; Healthy Ageing; Biological Aging Marker; Effect of Oral Nutritional Supplementation on Skin, Hair, Sleep, Energy, Cognition and Sexual Wellbeing in Healthy Adults

Keywords

collagen; dietary supplement; omega-3; skin elasticity; skin hydration; transepidermal water loss; hair density; sleep quality; cognition; healthy volunteers; healthspan; longevity; sleep; recovery; biological age; biological clock age; aging; ageing

Outcome Measures

Primary Outcomes (9)

• Change from baseline in skin elasticity

  Measured by Cutometer, left and right cheeks and centre forehead

  Baseline (Day 0), Day 28, Day 84

• Change from baseline in skin firmness

  Measured by Cutometer, left and right cheeks and centre forehead

  Baseline (Day 0), Day 28, Day 84

• Change from baseline in skin hydration

  Measured by Corneometer, left and right cheeks and centre forehead

  Baseline (Day 0), Day 28, Day 84

• Change from baseline in skin barrier function

  Transepidermal water loss measured by DermaLab SkinLab USB Series TEWL Probe, left and right cheeks and centre forehead

  Baseline (Day 0), Day 28, Day 84

• Change from baseline in skin radiance

  Trained assessor global assessment using Visual Analogue Scale

  Baseline (Day 0), Day 28, Day 84

• Change from baseline in fine lines and wrinkles

  Trained assessor grading using Roland Bazin scales for crow's feet wrinkles, crow's feet wrinkle depth and number, forehead wrinkles, glabella wrinkles and underneath eye wrinkles

  Baseline (Day 0), Day 28, Day 84

• Change from baseline in hair density

  C-Cube 2D image acquisition and analysis

  Baseline (Day 0), Day 84

• Change from baseline in hair shaft thickness

  C-Cube 2D image acquisition and analysis

  Baseline (Day 0), Day 84

• Change from baseline in hair count

  Baseline (Day 0), Day 84

  Baseline (Day 0), Day 84

Secondary Outcomes (4)

• Change from baseline in sleep quality

  Baseline (Day 0), Day 28, Day 84

• Change from baseline in perceived vitality and energy

  Baseline (Day 0), Day 28, Day 84

• Change from baseline in sexual wellbeing

  Baseline (Day 0), Day 28, Day 84

• Change from baseline in cognitive performance

  Baseline (Day 0), Day 84

Other Outcomes (3)

• Change from baseline in biological age

  Baseline (Day 0), Day 84

• Participant self-perception of product effects

  Day 28, Day 84

• High-definition digital facial imaging

  Baseline (Day 0), Day 28, Day 84

Study Arms (2)

Advanced ID Longevity and Collagen Complex Powder

EXPERIMENTAL

Two Advanced ID Brain, Heart and Eye Omega Gel Capsules followed by approximately 12 g (one scoop) Advanced ID Longevity and Collagen Complex Powder mixed with 400 ml water, taken orally once daily in the morning with food for 12 weeks.

Dietary Supplement: Advanced ID

Placebo Control

PLACEBO COMPARATOR

Two VitaMinute Organic Virgin Coconut Oil Softgel Capsules followed by approximately 12 g (one scoop) maltodextrin mixed with 400 ml water, taken orally once daily in the morning with food for 12 weeks.

Dietary Supplement: Placebo Control

Interventions

Advanced ID DIETARY_SUPPLEMENT

Combined regimen of Advanced ID Brain, Heart and Eye Omega Gel Capsules and Advanced ID Longevity and Collagen Complex Powder. Contains marine collagen (fish) and bovine gelatine.

Also known as: Advanced ID Brain, Heart and Eye Omega Gel Capsules, Advanced ID Longevity and Collagen Complex Powder

Advanced ID Longevity and Collagen Complex Powder

Placebo Control DIETARY_SUPPLEMENT

Virgin coconut oil softgel capsules and maltodextrin powder, matched in presentation to the active regimen.

Placebo Control

Eligibility Criteria

• Age: 35 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Healthy adults aged 35 to 65 years (30% male : 70% female desired)
• In generally good health, as determined by medical history questionnaire
• Free from excessive hair, tattoos, dermatitis or scars on the test areas; males must attend each visit clean shaven, having shaved the day before the appointment
• Able to read, understand and sign an informed consent agreement
• Able to communicate well with study personnel and comply with study requirements
• Hair at least 3 cm long, with no intention of substantial change to hair style
• Participants on medicinal contraception: stable method for at least 3 months prior to baseline and willing not to change for the study duration
• Women of childbearing potential: willing to use a reliable method of contraception
• Participants on hormone replacement therapy: stable HRT for at least 6 months prior to baseline and willing not to change
• Willing not to change regular food habits or commence any diet or nutritional change
• Willing to refrain from taking any new dietary supplements other than study products
• Willing to maintain usual lifestyle habits including exercise regimes
• Willing to avoid medicated shampoo and conditioner
• Willing to refrain from dermato-aesthetic facial procedures
• Willing to refrain from chemical hair styling procedures (colour treatments permitted)

You may not qualify if:

• \- Pregnant, breastfeeding, or of childbearing potential and not using reliable contraception
• Consumed any food or health supplements (including vitamins, creatine, omegas, collagen) within the 3 months prior to baseline
• Known allergy or hypersensitivity to any study product ingredient (products contain fish and coconut ingredients)
• Known allergy or hypersensitivity to any dietary supplements
• Any systemic condition (acute or chronic) or skin disorder including eczema, psoriasis, acne or diabetes (inactive skin disease for at least 6 months prior to baseline may be accepted at the Project Manager's discretion)
• History of skin cancer with remission period below 5 years
• Asthma or other chronic respiratory condition requiring therapy within the last 6 months
• Any other systemic disease or medical or skin condition which in the opinion of the Project Manager, Study Doctor or Sponsor would affect ability to complete the study
• Diagnosis of high cholesterol (current or previous)
• Current treatment with cholesterol lowering medication
• Family history of high cholesterol (first degree relative)
• Diagnosis of ischaemic heart disease (current or previous)
• Diagnosis of peripheral vascular disease or intermittent claudication
• Diagnosis of stroke (current or previous)
• Treatment (oral or topical) with tretinoin, isotretinoin or corticosteroids within the 6 months prior to baseline

Sponsors & Collaborators

• IDI Skincare Limited: lead
• University of Dublin, Trinity College: collaborator
• University of Edinburgh: collaborator

Study Sites (1)

Eurofins Product Testing Services Ltd (Eurofins Alba)

Edinburgh, EH1 3RH, United Kingdom

Location

MeSH Terms

Conditions

Sleep Initiation and Maintenance Disorders

Condition Hierarchy (Ancestors)

Sleep Disorders, Intrinsic; Dyssomnias; Sleep Wake Disorders; Nervous System Diseases; Mental Disorders

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Masking Details: The randomisation schedule was generated by an independent statistician using product codes only, via a centralised electronic randomisation system with provision for emergency unblinding. Access to the randomisation code was strictly controlled. Statistical analysts were also blinded to product identity at the time of analysis.
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Model Details: Two-arm parallel group design with 2:1 allocation of participants to the active supplement regimen and the placebo regimen respectively. Each participant received only one regimen for the full 12-week study period.

Study Record Dates

• First Submitted: September 14, 2026
• First Posted: September 18, 2026
• Study Start: December 8, 2025
• Primary Completion: March 5, 2026
• Study Completion (Estimated): November 30, 2026
• Last Updated: September 18, 2026

Record last verified: 2026-09

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)