NCT07821788

Brief Summary

This prospective cohort study aims to compare clinical outcomes and health-related quality of life between adults receiving established twice-weekly versus thrice-weekly maintenance hemodialysis at Assiut University Hospitals.

Trial Health

65
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
130

participants targeted

Target at P50-P75 for all trials

Timeline
16mo left

Started Sep 2026

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress5%
Sep 2026Feb 2028

First Submitted

Initial submission to the registry

September 10, 2026

Completed
Same day until next milestone

Study Start

First participant enrolled

September 10, 2026

Completed
6 days until next milestone

First Posted

Study publicly available on registry

September 16, 2026

Completed
12 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 10, 2027

Expected
5 months until next milestone

Study Completion

Last participant's last visit for all outcomes

February 10, 2028

Last Updated

September 17, 2026

Status Verified

September 1, 2026

Enrollment Period

1 year

First QC Date

September 10, 2026

Last Update Submit

September 15, 2026

Conditions

Kidney Failure, ChronicQuality of Life

Keywords

Twice-weekly hemodialysisThrice-weekly hemodialysisKDQOL-36Residual kidney functionQuality of life

Outcome Measures

Primary Outcomes (1)

  • Health-related quality of life score

    Mean total score of the Arabic Kidney Disease Quality of Life-36 (KDQOL-36) questionnaire. The KDQOL-36 score ranges from 0 to 100; higher scores indicate better health-related quality of life.

    At baseline, 3 months, and 6 months

Secondary Outcomes (5)

  • Dialysis adequacy

    Up to 6 months

  • Residual urine output

    Up to 6 months

  • Hospitalization rate

    Up to 6 months

  • Interdialytic weight gain

    Up to 6 months

  • Mortality

    Up to 6 months

Study Arms (2)

Twice-weekly hemodialysis

Adults receiving established twice-weekly maintenance hemodialysis.

Thrice-weekly hemodialysis

Adults receiving established thrice-weekly maintenance hemodialysis.

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Adults with end-stage kidney disease receiving maintenance in-center hemodialysis at Assiut University Hospitals.

You may qualify if:

  • \- Age 18 years or older
  • Established end-stage kidney disease requiring maintenance hemodialysis
  • Receiving in-center maintenance hemodialysis at Assiut University Hospitals
  • On maintenance hemodialysis for at least one month before enrollment
  • Established twice-weekly or thrice-weekly schedule prescribed by the treating team
  • Clinically stable at recruitment
  • Able to understand and respond to the questionnaire
  • Written informed consent

You may not qualify if:

  • \- Acute kidney injury without established end-stage kidney disease
  • Hemodialysis for less than one month
  • Peritoneal dialysis or kidney transplantation during follow-up
  • Acute severe illness requiring intensive care at recruitment
  • Severe cognitive, psychiatric or neurological impairment preventing reliable questionnaire responses
  • Active malignancy with expected survival too short to complete follow-up
  • Temporary dialysis solely for an acute indication
  • Refusal to participate
  • Permanent transfer to another dialysis center during follow-up

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (3)

  • Ackerman SD, Monk KR. The scales and tales of myelination: using zebrafish and mouse to study myelinating glia. Brain Res. 2016 Jun 15;1641(Pt A):79-91. doi: 10.1016/j.brainres.2015.10.011. Epub 2015 Oct 20.

    PMID: 26498880BACKGROUND

  • Hastaoglu F, Mollaoglu M. The effects of activities of daily living education on the independence and life satisfaction of elders. Perspect Psychiatr Care. 2022 Oct;58(4):2978-2985. doi: 10.1111/ppc.13149. Epub 2022 Aug 27.

    PMID: 36030386BACKGROUND

  • He XK, Su TT, Si JM, Sun LM. Metformin Is Associated With Slightly Reduced Risk of Colorectal Cancer and Moderate Survival Benefits in Diabetes Mellitus: A Meta-Analysis. Medicine (Baltimore). 2016 Feb;95(7):e2749. doi: 10.1097/MD.0000000000002749.

    PMID: 26886616BACKGROUND

MeSH Terms

Conditions

Kidney Failure, Chronic

Condition Hierarchy (Ancestors)

Renal Insufficiency, ChronicRenal InsufficiencyKidney DiseasesUrologic DiseasesFemale Urogenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesMale Urogenital DiseasesChronic DiseaseDisease AttributesPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Officials

  • marwa k abdo, prof

    Internal Medicine Department, Assiut University Hospitals

    STUDY CHAIR

Central Study Contacts

Justin g shawky, Resident

CONTACT

01281006606Justen.18313387@med.aun.edu.eg

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Target Duration
6 Months
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Resident Physician

Study Record Dates

First Submitted

September 10, 2026

First Posted

September 16, 2026

Study Start

September 10, 2026

Primary Completion (Estimated)

September 10, 2027

Study Completion (Estimated)

February 10, 2028

Last Updated

September 17, 2026

Record last verified: 2026-09