The Variation in Electrode Configuration for Termination of Out-of-Hospital Rhythms That Are Shockable in Cardiac Arrest Trial

NCT07818785 | Not Yet Recruiting DMC FDA Device

• 2 other identifiers: STUDY000303261033808
• Study Type: interventional
• Target: 1,500
• Locations: 0 countries
• Sites: N/A

Brief Summary

The purpose of this study is to compare the effectiveness of two defibrillator pad placements, one where pads are placed on the front of the chest and back (anterior-posterior \[AP\]) and one where the pads are placed on the front and side of the chest (anterior-lateral \[AL\]), for the treatment of cardiac arrest. Both pad placement locations are recommended for use by the American Heart Association (AHA) and International Liaison Committee on Resuscitation (ILCOR) and are used in standard treatment. The investigators are hoping to find out if one pad position is more effective than the other in the treatment of cardiac arrest.

Conditions

Cardiac Arrest (CA)

Outcome Measures

Primary Outcomes (1)

• Post-Shock Return of Spontaneous Circulation (ROSC)

  Any palpable pulse documented at any time after the first EMS shock

  day 1

Secondary Outcomes (7)

• Time to first rhythm analysis

  day 1

• Time to initial shock

  day 1

• Total EMS shocks

  day 1

• Time to ROSC

  day 1

• Survival to hospital admission

  day 1

Study Arms (2)

Anterior-Posterior

ACTIVE COMPARATOR

Defibrillation pads placed initially in the anterior-posterior position.

Device: defibrillator electrode pads

Anterior-Lateral

ACTIVE COMPARATOR

Defibrillation pads placed initially in the anterior-lateral position.

Device: defibrillator electrode pads

Interventions

defibrillator electrode pads DEVICE

Application of defibrillator electrode pads to be used in cardiac arrest treatment

Anterior-Lateral; Anterior-Posterior

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Emergency medical services (EMS)-treated non-traumatic out-of-hospital cardiac arrest

You may not qualify if:

• ROSC at EMS arrival (e.g., bystander AED shock with ROSC prior to EMS care) without rearrest during EMS care
• Known prisoners
• Known pregnant patients
• Known pediatric patients (treated under the pediatric algorithm, generally \<15 years)
• Known preexisting do-not-resuscitate orders limiting care

Sponsors & Collaborators

• Oregon Health and Science University: lead

MeSH Terms

Conditions

Heart Arrest

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases

Central Study Contacts

Joshua Lupton, MD, MPH

CONTACT

503-418-6706; lupton@ohsu.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: September 4, 2026
• First Posted: September 14, 2026
• Study Start (Estimated): April 1, 2027
• Primary Completion (Estimated): June 30, 2029
• Study Completion (Estimated): December 31, 2029
• Last Updated: September 14, 2026

Record last verified: 2026-09

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP
• Time Frame: Within 12 months from study completion. No end date.
• Access Criteria: Stored in dataverse via request and data use agreement process