Adapted Cardiopulmonary Resuscitation Study

NCT07754656 | Recruiting

• 1 other identifier: JKULinz
• Study Type: interventional
• Target: 216
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this controlled single centre RCT is to compare frequency rates concerning return of spontaneous circulation (ROSC) in prehospital cardiac arrest. Two different algorithms (control-and interventiongroup) of advanced cardiac life support will be used to treat patients. In patients over 18 years suffering from cardiac arrest. The main question aims to answer if the frequency of ROSC differs between the groups receiving either the new Advanced Life Support (ALS) algorithm, or standard treatment. Researchers will compare the new algorithm to the standard care algorithm to see if there is a difference . Participants will be randomized to treatment on scene. The controlgroup will receive ALS standard treatment as performed in local protocols. The intervention group will receive a modified treatment including:

• thorax compression via mechanical device (LUCAS 3)
• head up Cardiopulmonary Resuscitation (cpr)
• use of an impendance threshold device (ITD) module
• arterial line placement
• continuous epinephrin infusion via infusion pump
• double sequence defibrillation

Conditions

Cardiac Arrest (CA)

Keywords

cardiac arrest; head up cpr; continuous adrenalin infusion; mechanical thorax compression; ITD; arterial line; diastolic blood pressure; ROSC; OHCA

Outcome Measures

Primary Outcomes (1)

• ROSC

  frequency of ROSC in the study cohort

  one minute

Secondary Outcomes (3)

• Time to ROSC

  Periprocedural: from enrollement to ROSC or Termination of Resuscitation (TOR)

• CO2

  Periprocedural: from enrollement to ROSC orTOR

• descriptive data

  Periprocedural: during study intervention

Study Arms (2)

ALS ERC 2025

ACTIVE COMPARATOR

Procedure: ERC ALS 2025

adapted CPR algorithm

EXPERIMENTAL

* thorax compression via mechanical device (LUCAS 3) * head up cpr * use of an ITD module * arterial line placement * continuous epinephrin infusion via infusion pump * double sequence defibrillation

Procedure: aCPR algorithm

Interventions

aCPR algorithm PROCEDURE

* thorax compression via mechanical device (LUCAS 3) * head up cpr * use of an ITD module * arterial line placement * continuous epinephrin infusion via infusion pump * double sequence defibrillation

adapted CPR algorithm

ERC ALS 2025 PROCEDURE

Placement of an IV line, placement of a supraglottic airway device or endotracheal intubation. Optional use of an intraosseus acces

ALS ERC 2025

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age\> 18 years
• time of resuscitation \<21 minutes when enrollement starts

You may not qualify if:

• obvious pregnancy
• contraindications for the use of Lucas 3
• time of resuscitation \>21 minutes and etCO2 \<15 mmHg upon arrival of the emergency physician on scene

Sponsors & Collaborators

• Johannes Kepler University of Linz: lead
• Red Cross Upper Austria: collaborator
• Kepler University Hospital: collaborator

Study Sites (1)

Kepler University Hospital

Linz, Upper Austria, 4020, Austria

RECRUITING

MeSH Terms

Conditions

Heart Arrest

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases

Study Officials

• Jens Meier, Univ. Prof.

  Kepler University Hospital / Johannes Kepler University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 8, 2026
• First Posted: August 10, 2026
• Study Start: January 28, 2026
• Primary Completion (Estimated): January 28, 2029
• Study Completion (Estimated): March 28, 2029
• Last Updated: August 10, 2026

Record last verified: 2026-08

Data Sharing

• IPD Sharing: Will not share

Locations

AU (1)