Quality of Life After Lower Respiratory Tract Infection

NCT07807917 | Not Yet Recruiting

• 1 other identifier: 26019
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

Lower respiratory tract infections (LRTIs) are any infections below the vocal cords which affect the airways or the air sacs in the lungs. They include pneumonia, bronchitis and chest infections and are usually caused by viruses such as influenza, COVID-19 or Respiratory Syncytial Virus (RSV), or by bacteria such as pneumococcus. LRTIs are common, particularly in older adults; in the UK approximately 15% of people aged over 65 years will experience a chest infection each year and many of those will need in-patient treatment. People who have had a chest infection may experience slow recovery after their infection. Patients often report that their quality of life is worse after an infection (for example persistent fatigue, reduced physical functioning, and mental health challenges) and this can affect the return to usual activities. However, there have not been many studies that have looked at how the quality of life changes in the months following a chest infection, and why some people take longer to recover. In this study, the investigators will use a well-recognised questionnaire to measure quality of life for up to one year in adults who have been admitted to hospital with a chest infection. The findings will help the investigators to assess how long-term quality of life is affected after a chest infection and what factors may affect it. The results will also permit calculation of the costs faced by patients during recovery from a chest infection, in financial terms. These results will feed into studies looking at ways of improving recovery after a chest infection.

Conditions

Lower Respiratory Tract Infection (LRTI); Chest Infection; Quality of Life

Keywords

Lower respiratory tract infection; Chest infection; Pneumonia; Quality of life; EQ-5D-5L

Outcome Measures

Primary Outcomes (1)

• Change from baseline in health state utility values over one year

  Health state utility values calculated from EQ-5D-5L profiles using preference-based value sets pre-discharge and at 1, 3, 6 and 12 months post-discharge.

  From enrolment to one year post-discharge from hospital

Study Arms (1)

Lower respiratory tract infection

Adults hospitalised with a lower respiratory tract infection (low, moderate or severe severity).

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Participants will be recruited from the adult respiratory wards at Nottingham City Hospital as the majority of patients with a primary diagnosis of lower respiratory tract infection are admitted to these wards.

You may qualify if:

• Adults aged ≥18years (no upper age limit).
• Treated by attending physician as lower respiratory tract infection/community-acquired pneumonia, regardless of microbiologically-confirmed pathogen.
• Ability to give informed consent or appropriate consultee available to give advice.

You may not qualify if:

• Hospital admission within 14 days preceding the index admission
• Post-obstructive pneumonia secondary to Lung Cancer
• Patients treated for active Tuberculosis (TB)
• Receiving palliative treatment only
• Unable to understand written or spoken English
• Presumed to be unable to answer the questionnaires over the follow-up period.
• Exacerbations of chronic lung disease such as asthma, COPD or bronchiectasis.
• Previously enrolled in the study.

Sponsors & Collaborators

• University of Nottingham: lead

Study Sites (1)

Nottingham City Hospital

Nottingham, NG5 1PB, United Kingdom

Location

Related Publications (7)

• Pick HJ, Bolton CE, Lim WS, McKeever TM. Patient-reported outcome measures in the recovery of adults hospitalised with community-acquired pneumonia: a systematic review. Eur Respir J. 2019 Mar 18;53(3):1802165. doi: 10.1183/13993003.02165-2018. Print 2019 Mar.

  PMID: 30635298 BACKGROUND

• Baskaran V, Lim WS, McKeever TM. Effects of tobacco smoking on recurrent hospitalisation with pneumonia: a population-based cohort study. Thorax. 2022 Jan;77(1):82-85. doi: 10.1136/thoraxjnl-2020-216494. Epub 2021 Jun 18.

  PMID: 34145048 BACKGROUND

• Violi F, Cangemi R, Falcone M, Taliani G, Pieralli F, Vannucchi V, Nozzoli C, Venditti M, Chirinos JA, Corrales-Medina VF; SIXTUS (Thrombosis-Related Extrapulmonary Outcomes in Pneumonia) Study Group. Cardiovascular Complications and Short-term Mortality Risk in Community-Acquired Pneumonia. Clin Infect Dis. 2017 Jun 1;64(11):1486-1493. doi: 10.1093/cid/cix164.

  PMID: 28205683 BACKGROUND

• Baskaran V, Pearce F, Harwood RH, McKeever TM, Lim WS. Primary care consultations after hospitalisation for pneumonia: a large population-based cohort study. Br J Gen Pract. 2021 Mar 26;71(705):e250-e257. doi: 10.3399/BJGP.2020.0890. Print 2021 Apr.

  PMID: 33753348 BACKGROUND

• Eurich DT, Marrie TJ, Minhas-Sandhu JK, Majumdar SR. Risk of heart failure after community acquired pneumonia: prospective controlled study with 10 years of follow-up. BMJ. 2017 Feb 13;356:j413. doi: 10.1136/bmj.j413.

  PMID: 28193610 BACKGROUND

• Lawrence H, McKeever TM, Lim WS; British Thoracic Society. Readmission following hospital admission for community-acquired pneumonia in England. Thorax. 2023 Dec;78(12):1254-1261. doi: 10.1136/thorax-2022-219925. Epub 2023 Jul 31.

  PMID: 37524392 BACKGROUND

• Han JH, Resser JJ, Baughman A, Grijalva CG, Johnson J, Miller KF, Roberts CS, Johnson KD, Weiss T, Self WH; PNEUMO Study Investigators. Community-acquired pneumonia in hospitalized adults: long-term morbidities and their risk factors. BMC Infect Dis. 2025 Jul 1;25(1):826. doi: 10.1186/s12879-025-11186-w.

  PMID: 40597744 BACKGROUND

MeSH Terms

Conditions

Pneumonia

Condition Hierarchy (Ancestors)

Respiratory Tract Infections; Infections; Lung Diseases; Respiratory Tract Diseases

Central Study Contacts

Professor Tricia McKeever

CONTACT

+44 (0)115 8231721; tricia.mckeever@nottingham.ac.uk

Jhon Galindo-Rodriguez

CONTACT

Jhon.Galindo-Rodriguez@nottingham.ac.uk

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 1, 2026
• First Posted: September 8, 2026
• Study Start: September 1, 2026
• Primary Completion (Estimated): September 1, 2028
• Study Completion (Estimated): September 1, 2028
• Last Updated: September 30, 2026

Record last verified: 2026-08

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)