An Observational Study of Cough / Lower Respiratory Tract Infection (LRTI) in Primary Care

NCT00353951 | Completed

• 1 other identifier: GRACE-01
• Study Type: observational
• Target: 3,402
• Locations: 1 country
• Sites: 1

Brief Summary

The overall objective of GRACE is to combat the resistance of drugs that kill bacteria and other germs (antimicrobial) through integrating centres of research excellence and using the study of the entire DNA in a cell (genomics) to most appropriately investigate and manage community-acquired LRTI. Grace-01 is the first study to be undertaken as part of GRACE and the aims of this study are to describe the presentation, diagnosis, investigation, management and outcomes for people with cough / chest infection in general medical practice in 13 primary care networks in 12 countries in Europe.

Conditions

Cough; Lower Respiratory Tract Infection (LRTI); Chest Infection

Keywords

primary care; lower respiratory tract infection; antibiotics; cough

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Aged 18 years and over.
• With acute or worsened cough with a duration of up to and including 28 days, or a clinical presentation that suggests a lower respiratory tract infection.
• Consulting for the first time within this illness episode.
• Seen within normal consulting hours.
• Able to fill out study materials.
• Who have provided written, informed consent to participate.

You may not qualify if:

• Previous study participants.
• Immunocompromised.

Sponsors & Collaborators

• Cardiff University: lead
• European Commission: collaborator
• University of Southampton: collaborator
• Universiteit Antwerpen: collaborator
• Utrecht University: collaborator

Study Sites (1)

GRACE Network in Cardiff

Cardiff, CF5 4AD, United Kingdom

Location

Related Publications (4)

• Nuttall J, Hood K, Verheij TJ, Little P, Brugman C, Veen RE, Goossens H, Butler CC. Building an international network for a primary care research program: reflections on challenges and solutions in the set-up and delivery of a prospective observational study of acute cough in 13 European countries. BMC Fam Pract. 2011 Jul 27;12:78. doi: 10.1186/1471-2296-12-78.

  PMID: 21794112 DERIVED

• Butler CC, Kelly MJ, Hood K, Schaberg T, Melbye H, Serra-Prat M, Blasi F, Little P, Verheij T, Molstad S, Godycki-Cwirko M, Edwards P, Almirall J, Torres A, Rautakorpi UM, Nuttall J, Goossens H, Coenen S. Antibiotic prescribing for discoloured sputum in acute cough/lower respiratory tract infection. Eur Respir J. 2011 Jul;38(1):119-25. doi: 10.1183/09031936.00133910. Epub 2011 Mar 15.

  PMID: 21406512 DERIVED

• Stanton N, Hood K, Kelly MJ, Nuttall J, Gillespie D, Verheij T, Little P, Godycki-Cwirko M, Goossens H, Butler CC. Are smokers with acute cough in primary care prescribed antibiotics more often, and to what benefit? An observational study in 13 European countries. Eur Respir J. 2010 Apr;35(4):761-7. doi: 10.1183/09031936.00168409. Epub 2009 Dec 23.

  PMID: 20032009 DERIVED

• Butler CC, Hood K, Verheij T, Little P, Melbye H, Nuttall J, Kelly MJ, Molstad S, Godycki-Cwirko M, Almirall J, Torres A, Gillespie D, Rautakorpi U, Coenen S, Goossens H. Variation in antibiotic prescribing and its impact on recovery in patients with acute cough in primary care: prospective study in 13 countries. BMJ. 2009 Jun 23;338:b2242. doi: 10.1136/bmj.b2242.

  PMID: 19549995 DERIVED

MeSH Terms

Conditions

Cough

Condition Hierarchy (Ancestors)

Respiration Disorders; Respiratory Tract Diseases; Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Christopher C Butler, FRCGP CCH MD

  Cardiff University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: July 18, 2006
• First Posted: July 19, 2006
• Study Start: September 1, 2006
• Primary Completion: July 1, 2007
• Study Completion: July 1, 2007
• Last Updated: May 20, 2008

Record last verified: 2008-05

Locations

GB (1)