Patient Pain and Function in Medial Knee Osteoarthritis After Anteromedial vs Anterolateral Intra-Articular Corticosteroid Injection

NCT07804446 | Recruiting

• 1 other identifier: IRB26-0169
• Study Type: interventional
• Target: 140
• Locations: 1 country
• Sites: 5

Brief Summary

The primary purpose of this study is to find out if there is a difference in pain experienced in patients with knee arthritis of the inside of their knee if they get a steroid injection on the inside or outside of their knee. Participants will:

1. 1.Be randomly divided into getting their steroid injection on the inside or outside of their knee.
2. 2.Answer a pain survey before their injection as well as over the phone 2 weeks, 6 weeks, and 12 weeks after their injection.

Conditions

Osteoarthitis; Osteoarthritic Knee Pain; Osteoarthritis (OA); Osteoarthritis (OA) of the Knee; Osteoarthritis in the Knee

Keywords

osteoarthritis; arthritis; corticosteroid; steroid injection; pain; pain control; pain survey; knee; knee arthritis; knee osteoarthritis; knee pain; knee injection

Outcome Measures

Primary Outcomes (2)

• Numeric Pain Rating Scale

  This survey asks patients to rate their pain on a scale from 0 to 10.

  Pre-procedure, 2 weeks, 6 weeks, and 12 weeks post-injection

• Knee Osteoarthritis and Outcome Score-Joint Replacement

  This standardized survey asks patients to describe the impact of their knee stiffness and pain on daily tasks.

  Pre-procedure, 2 weeks, 6 weeks, and 12 weeks post-injection

Secondary Outcomes (2)

• Institutional Survey on Satisfaction with Injection

  2 weeks, 6 weeks, and 12 weeks post-injection

• Patient Global Impression of Change

  2 weeks, 6 weeks, and 12 weeks post-injection

Study Arms (2)

Anterolateral

ACTIVE COMPARATOR

These patients will receive their corticosteroid injections on their anterolateral knees.

Procedure: Anterolateral Injection

Anteromedial

ACTIVE COMPARATOR

This group of patients will receive injections on the anteromedial side of their knee.

Procedure: Anteromedial Injection

Interventions

Anteromedial Injection PROCEDURE

If randomized to this intervention, patients will receive a corticosteroid injection in the anteromedial side of their knee.

Anteromedial

Anterolateral Injection PROCEDURE

If randomized to this intervention, patients will receive a corticosteroid injection on the anterolateral side of their knee.

Anterolateral

Eligibility Criteria

• Age: 40 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age ≥ 40
• Clinical diagnosis of knee OA with predominant medial compartment symptoms
• Radiographic moderate-to-severe medial compartment OA (KL grade 3-4 or equivalent)
• Agreed to and preparing to receive a CSI of the knee as part of standard care from surgeon, regardless of past injection of the knee
• Able to provide informed consent
• Able to complete phone, email, or MyChart follow-ups in English

You may not qualify if:

• Predominant lateral compartment OA or patellofemoral-only OA
• Inflammatory arthritis (RA, gout flare, etc.)
• Suspected or confirmed joint infection or overlying cellulitis
• Prior knee arthroplasty on the index knee
• Planned surgery for index knee within 12-week follow-up
• Inability to complete follow-up assessments
• Other clinician-determined contraindication to CSI

Sponsors & Collaborators

• University of Chicago: lead
• AdventHealth: collaborator

Study Sites (5)

Bolingbrook Clinic

Bolingbrook, Illinois, 60440, United States

RECRUITING

Hyde Park Clinic

Chicago, Illinois, 60637, United States

RECRUITING

La Grange Clinic

La Grange, Illinois, 60525, United States

RECRUITING

Orland Park Clinic

Orland Park, Illinois, 60462, United States

RECRUITING

Woodridge Clinic

Woodridge, Illinois, 60517, United States

RECRUITING

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MeSH Terms

Conditions

Osteoarthritis; Arthritis; Pain; Agnosia; Osteoarthritis, Knee

Condition Hierarchy (Ancestors)

Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Perceptual Disorders; Neurobehavioral Manifestations; Nervous System Diseases

Study Officials

• Sara JS Wallace, M.D./M.P.H.

  The University of Chicago Medical Center

  PRINCIPAL INVESTIGATOR

• Brandon Pardi, M.D.

  AdventHealth

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Malik J Scott, B.A.

CONTACT

773-834-3531; mjscott1@uchicago.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: The population will be adults with symptomatic, radiographically moderate-to-severe medial compartment knee osteoarthritis who are already undergoing corticosteroid injections as part of routine care on their native knee. They wil be randomized to receive their injection on either the anteromedial or anterolateral knee.

Study Record Dates

• First Submitted: August 31, 2026
• First Posted: September 4, 2026
• Study Start: August 31, 2026
• Primary Completion (Estimated): April 1, 2027
• Study Completion (Estimated): May 1, 2027
• Last Updated: September 4, 2026

Record last verified: 2026-08

Locations

US (5)