Low Dose Radiotherapy for Osteoarthritis
A Prospective Study of Low Dose Radiotherapy for Osteoarthritis
1 other identifier
interventional
113
1 country
2
Brief Summary
This single institution, multi-site, single arm prospective study will enroll patients with a history of OA and assess changes in pain and function after treatment with LDRT as measured by patient-reported outcomes.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Jun 2026
Typical duration for not_applicable
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 24, 2026
CompletedFirst Submitted
Initial submission to the registry
July 15, 2026
CompletedFirst Posted
Study publicly available on registry
July 20, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2029
ExpectedStudy Completion
Last participant's last visit for all outcomes
June 1, 2029
July 20, 2026
July 1, 2026
2.9 years
July 15, 2026
July 15, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
To measure the percentage of subjects who experience a best response of 1 point or more on BPI-SF
Assess the degree of patient-reported pain prior to and after use of 1-2 courses of LDRT
Within 1 year
Secondary Outcomes (4)
To measure the percentage of subjects who experience a best response of 1 point or more on BPI-SF
at ~ 3 months
To measure change in PROMIS scores
From baseline at 3-month and 1-year follow-up
To measure change in LEFS scores as measured
From baseline at 3-month and 1-year follow-up
To measure change in UEFI scores as measured
From baseline at 3-month and 1-year follow-up
Study Arms (1)
Single
OTHERParticipants will complete study intervention which consists of the BPI-SF, PROMIS Global v1.2, UEFI (for those with joint pain of the upper extremity) and/or LEFS (for those joint pain of the lower extremity) at baseline, 3-month and 1-year follow-up following 1 or 2 courses of standard of care LDRT.
Interventions
Participants will complete study intervention which consists of the BPI-SF, PROMIS Global v1.2, UEFI (for those with joint pain of the upper extremity) and/or LEFS (for those joint pain of the lower extremity) at baseline, 3-month and 1-year follow-up following 1 or 2 courses of standard of care LDRT.
Eligibility Criteria
You may qualify if:
- years or older
- Diagnosis of OA \>3 months in hips, knees, hands, shoulders, ankles or elbows.
- Refractory to standard of care therapies for OA or those who are being considered for more aggressive interventional treatment such as joint replacement, but more conservative treatment is desired.
- Provision of signed and dated informed consent.
You may not qualify if:
- Unable to reasonably complete study instruments.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
Penn Presbyterian Medical Center
Philadelphia, Pennsylvania, 19104, United States
Perelman Center for Advanced Medicine
Philadelphia, Pennsylvania, 19104, United States
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
July 15, 2026
First Posted
July 20, 2026
Study Start
June 24, 2026
Primary Completion (Estimated)
June 1, 2029
Study Completion (Estimated)
June 1, 2029
Last Updated
July 20, 2026
Record last verified: 2026-07
Data Sharing
- IPD Sharing
- Will not share