NCT07803328|Not Yet Recruiting
Perioperative Role Of Vascular Endothelial Growth Factor In Cardiac Surgery-associated Acute Kidney Injury
PROVE-AKI
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PROVE-AKI
Sponsor study identifier
observational
220
1 country
1
Study Start
September 1, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
April 30, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
May 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
The goal of this prospective observational study is to find out whether the protein vascular endothelial growth factor (VEGF) measured in blood and urine can predict which patients will develop acute kidney injury (AKI) after heart-type surgery that uses a heart-lung machine (cardiopulmonary bypass).
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
May 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
August 27, 2026
Actual (reported)September 1, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
September 3, 2026
Actual (reported)April 30, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
May 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Association of vascular endothelial growth factor (VEGF) levels with postoperative acute kidney injury
From baseline to postoperative day 3
Difference in VEGF levels between patients with and without chronic kidney disease
From Baseline to postoperative day 3
Difference in VEGF levels between patients with transient and persistent acute kidney injury (AKI) after cardiac surgery
Up to 30 days postoperatively
Association of VEGF levels with length of ICU-stay
Up to 30 days postoperatively
Association of VEGF levels with length of hospital stay
Up to 30 days postoperatively
Association of VEGF levels with 30-day all-cause mortality
From enrolment to postoperative day 30
Adult patients undergoing elective cardiac surgery with use of cardiopulmonary bypass
University Muenster, University Hospital Muenster, Department of Anesthesiology, Intensive Care and Pain Medicineperative
Münster, 48149, Germany
Plasma, Urine
First Submitted
August 27, 2026
First Posted
September 3, 2026
Study Start
September 1, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
April 30, 2027
EstimatedNephroprotective Measures in Critically Ill Patients With Moderate/Severe Acute Kidney Injury
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Planned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
May 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
September 3, 2026
Record last verified: 2026-08
Individual participant data that underlie the results reported in this study, after deidentification (text, tables, figures, and appendices)
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Source: ClinicalTrials.gov.
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