Efficacy of a Novel Nanoparticle -Augmented Disinfection Protocol

NCT07800403 | Recruiting DMC

• 1 other identifier: Novel Nanoparticle
• Study Type: interventional
• Target: 28
• Locations: 1 country
• Sites: 1

Brief Summary

The ultimate biological aim of endodontic therapy is to either prevent or heal apical periodontitis. Root canal treatment can fail for various reasons, such as persistent infection, missing canals, ledges, canal transportation, instrument separation, and perforation. Post-treatment apical periodontitis is an inflammatory response in the tissues surrounding the root tip, triggered by either lingering bacteria from the initial procedure or a new, secondary infection within the canal system. Statistically, this condition affects roughly 5% to 20% of cases where apical periodontitis was present before the initial treatment.

Conditions

Post Operative Pain

Outcome Measures

Primary Outcomes (1)

• Post Operative Pain

  Evaluation of the cases from the pain after the procedures by using point numeric rating scale by another operator at 24, 48 and 72-hours.

  from 24 hours to 72 hours after the procedures

Study Arms (2)

Non- surgical retreatment Novel Nanoparticle (NSRN)

ACTIVE COMPARATOR

About 14 cases will be irrigated with 5 ml of Novel Nanoparticle -Augmented irrigation placed in the root canal and activated passively with woodpecker ultrasonic (Guilin Woodpecker Medical Instrument Co., Ltd., China) for 3 cycle 20 seconds.

Procedure: Novel Nanoparticle

Non -surgical root canal retreatment (NSRC)

ACTIVE COMPARATOR

About 14 cases will be irrigated with 5 ml of (2.5%) NaOCl placed in the root canal and activated passively with woodpecker ultrasonic scaler (Guilin Woodpecker Medical Instrument Co., Ltd., China) for 3 cycle 20 seconds.

Procedure: Novel Nanoparticle

Interventions

Novel Nanoparticle PROCEDURE

To evaluate efficacy of a Novel Nanoparticle -Augmented Disinfection Protocol in the Non -Surgical Retreatment of Maxillary Anterior Teeth with Periapical Lesions in Type II Diabetic Patients

Also known as: Non -Surgical Retreatment of Maxillary Anterior Teeth

Non -surgical root canal retreatment (NSRC); Non- surgical retreatment Novel Nanoparticle (NSRN)

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Diabetic patients type II of either gender aged from 18-40 years
• Permanent mature Maxillary anterior teeth having a baseline periapical lesion (PAI score ≥3).

You may not qualify if:

• Immuno-compromised patients.
• Pregnant women and smokers.
• Patients with a history of antibiotic or analgesics intake within the few days before the endodontic treatment.
• Teeth with root fractures or perforations.
• Teeth with lesions connected to adjacent teeth.

Sponsors & Collaborators

• Minia University: lead

Study Sites (1)

Minia University, Faculty of Dentistry

Minya, Egypt

RECRUITING

MeSH Terms

Conditions

Pain, Postoperative

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Study Officials

• Dalia Ali Ahmed Moukarab, Professor

  Professor of Endodontics Head of Endodontic Department,Faculty of Dentistry,Future University

  STUDY CHAIR

Central Study Contacts

Ebthal Hamada Saleh, MSC

CONTACT

+201037570153; ebthalhamada9@gmail.com

Dalia Ali Ahmed Moukarab, M.D

CONTACT

+201068121523; dalia.mokarab@mu.edu.eg

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant lecturer at Endodontics Department,Faculty of Dentistry

Study Record Dates

• First Submitted: August 29, 2026
• First Posted: September 2, 2026
• Study Start: July 14, 2026
• Primary Completion (Estimated): July 7, 2027
• Study Completion (Estimated): July 14, 2027
• Last Updated: September 2, 2026

Record last verified: 2026-07

Locations

EG (1)