Effect of NeoSEALER FLO and AH Plus Resin Sealer on Postoperative Pain and Healing of Periapical Lesions
1 other identifier
interventional
30
1 country
1
Brief Summary
Tissue repair is an essential process that reestablishes tissue integrity and regular function. Nevertheless, different therapeutic factors and clinical conditions may interfere in this process of periapical healing.The success of root canal treatment is affected by the correct choice of clinical protocol. These factors are dependent on the sanitization process (instrumentation, irrigating solution, irrigating strategies, and intracanal dressing) the apical limit of the root canal preparation and obturation, and the quality of the sealer. The challenges affecting the healing process of endodontically treated teeth include control of the inflammation of pulp or infectious processes and simultaneous neutralization of unpredictable provocations to the periapical tissue.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Aug 2026
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 1, 2026
CompletedFirst Submitted
Initial submission to the registry
August 21, 2026
CompletedFirst Posted
Study publicly available on registry
August 25, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 1, 2027
ExpectedStudy Completion
Last participant's last visit for all outcomes
August 10, 2027
August 25, 2026
August 1, 2026
1 year
August 21, 2026
August 21, 2026
Conditions
Outcome Measures
Primary Outcomes (1)
Treatment of Postoperative Pain
Patients will be evaluated for postoperative pain via (NRS) to record the intensity of pain.as follows: 0 reading represents "no pain" ; 1- 3 reading represents "mild pain" ; 4- 6 reading represents "moderate pain" and 7- 10 reading represents "severe pain".
from 0 hours to 2 weeks after the procedure
Secondary Outcomes (1)
Periapical Healing
After 6 months to 12 months
Study Arms (2)
AH plus sealer
ACTIVE COMPARATORAbout 15 cases will undergo the AH plus sealer during obturation After complete preparation of the root canal system
NeoSEALER FLO
ACTIVE COMPARATORAbout 15 cases will undergo the Neo Sealer FLO during obturation After complete preparation of the root canal system
Interventions
to evaluate and compare postoperative pain and periapical healing after root canal treatment using two different base endodontic sealers: * NeoSEALER Flo * AH plus Resin sealer
Eligibility Criteria
You may qualify if:
- Patients with mature permanent teeth.
- Patients with apical periodontitis.
- Maxillary anterior teeth only will be involved.
- Patients should be free from any systemic disease that may affect normal healing and predictable outcome.
- Patients who will agree to the consent and will commit to follow-up period.
- The selected teeth should have periapical lesion score ≤3
You may not qualify if:
- Patients with immature canals.
- Patients with swelling.
- Pregnant females.
- Patients who could/would not participate in a 1-year follow-up.
- Geriatric patients.
- Patients with old age.
- Teeth with periodontal involvement.
- Teeth with vertical root fractures.
- Non-restorable teeth.
- cases with previously initiated endodontic treatment.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Minia Universitylead
Study Sites (1)
Minia University, Faculty of Dentistry
Minya, Egypt
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Maged Mohamed Negm, M.D
Professor of Endodontics, Faculty of Dentistry,Cairo University
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assistant lecturer at Endodontics Department,Faculty of Dentistry,Lotus University
Study Record Dates
First Submitted
August 21, 2026
First Posted
August 25, 2026
Study Start
August 1, 2026
Primary Completion (Estimated)
August 1, 2027
Study Completion (Estimated)
August 10, 2027
Last Updated
August 25, 2026
Record last verified: 2026-08